Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats
Diabetic encephalopathy is one of the complications of diabetes. Cognitive dysfunction is the main consequence. Previous findings from neuroanatomical and in vitro electrophysiological studies showed that the structure and function of the hippocampus is impaired in diabetes, which may underlie the c...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/626108 |
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| author | Zhimei Qiao Kangning Xie Kai Liu Guoliang Li |
| author_facet | Zhimei Qiao Kangning Xie Kai Liu Guoliang Li |
| author_sort | Zhimei Qiao |
| collection | DOAJ |
| description | Diabetic encephalopathy is one of the complications of diabetes. Cognitive dysfunction is the main consequence. Previous findings from neuroanatomical and in vitro electrophysiological studies showed that the structure and function of the hippocampus is impaired in diabetes, which may underlie the cognitive dysfunction induced by diabetes. However the study of electrophysiological abnormality of hippocampal neurons in intact networks is sparse. In the current study, we recorded the spontaneous firing of neurons in hippocampal CA1 area in anesthetized streptozotozin (STZ)-diabetic and age-matched control rats. Profound reduction in burst activity was found in diabetic rats. Compared to control rats, the intra-burst inter-spike intervals were prolonged significantly in diabetic rats, while the burst ratio and the mean number of spikes within a burst decreased significantly. Treatment with APP 17-mer peptide retarded the effects of diabetes on these parameters. In addition, the average PLV of diabetic rats was lower than that of control rats. These findings provide in vivo electrophysiological evidence for the impairment of hippocampal function in STZ-diabetic rats, and may have some implications in the mechanisms associated with cognitive deficits in diabetes. |
| format | Article |
| id | doaj-art-dd393767db2e4c6cb3ad3b8d79aae5ee |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-dd393767db2e4c6cb3ad3b8d79aae5ee2025-08-20T02:21:33ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/626108626108Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic RatsZhimei Qiao0Kangning Xie1Kai Liu2Guoliang Li3Key Laboratory of Brain Functional Genomics (MOE & STCSM), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, No. 3663 North Zhongshan Road, Shanghai 200062, ChinaDepartment of Biomedical Engineering, School of Medicine, Tsinghua University, No. 16 Shuangqing Road, Beijing 100084, ChinaDepartment of Biomedical Engineering, School of Medicine, Tsinghua University, No. 16 Shuangqing Road, Beijing 100084, ChinaDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, ChinaDiabetic encephalopathy is one of the complications of diabetes. Cognitive dysfunction is the main consequence. Previous findings from neuroanatomical and in vitro electrophysiological studies showed that the structure and function of the hippocampus is impaired in diabetes, which may underlie the cognitive dysfunction induced by diabetes. However the study of electrophysiological abnormality of hippocampal neurons in intact networks is sparse. In the current study, we recorded the spontaneous firing of neurons in hippocampal CA1 area in anesthetized streptozotozin (STZ)-diabetic and age-matched control rats. Profound reduction in burst activity was found in diabetic rats. Compared to control rats, the intra-burst inter-spike intervals were prolonged significantly in diabetic rats, while the burst ratio and the mean number of spikes within a burst decreased significantly. Treatment with APP 17-mer peptide retarded the effects of diabetes on these parameters. In addition, the average PLV of diabetic rats was lower than that of control rats. These findings provide in vivo electrophysiological evidence for the impairment of hippocampal function in STZ-diabetic rats, and may have some implications in the mechanisms associated with cognitive deficits in diabetes.http://dx.doi.org/10.1155/2014/626108 |
| spellingShingle | Zhimei Qiao Kangning Xie Kai Liu Guoliang Li Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats Journal of Diabetes Research |
| title | Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats |
| title_full | Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats |
| title_fullStr | Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats |
| title_full_unstemmed | Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats |
| title_short | Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats |
| title_sort | decreased neuronal bursting and phase synchrony in the hippocampus of streptozotocin diabetic rats |
| url | http://dx.doi.org/10.1155/2014/626108 |
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