Cardiac involvement in dengue infection
Introduction: Dengue is endemic in the tropics, and complications involving organ systems are seen with varying incidence. Methodology: We performed a systematic review. MEDLINE, EMBASE, Scopus SciVerse, Google Scholar, and LILACS were searched for papers providing information on cardiac involvemen...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2015-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/6200 |
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| author | Mitrakrishnan C Shivanthan Mitrakrishnan R Navinan Godwin Roger Constantine Senaka Rajapakse |
| author_facet | Mitrakrishnan C Shivanthan Mitrakrishnan R Navinan Godwin Roger Constantine Senaka Rajapakse |
| author_sort | Mitrakrishnan C Shivanthan |
| collection | DOAJ |
| description | Introduction: Dengue is endemic in the tropics, and complications involving organ systems are seen with varying incidence.
Methodology: We performed a systematic review. MEDLINE, EMBASE, Scopus SciVerse, Google Scholar, and LILACS were searched for papers providing information on cardiac involvement in dengue.
Results: Cardiac involvement is not uncommon in dengue infection and is often transient, but may be associated with significant morbidity and even mortality. Direct viral invasion, immune mechanisms, electrolyte imbalance, derangement of intracellular calcium ion storage, lactic acidosis, and ischemia due to hypotension all play a role in myocardial dysfunction. The manifestations of cardiac involvement include clinical, electrocardiographic, echocardiographic, cardiac enzyme, and histopathologic abnormalities. Echocardiography appears to be a useful tool for detecting myocardial involvement and should be performed in patients with electrocardiographic abnormalities or hemodynamic instability. Treatment is largely supportive, though there are some anecdotal reports of improvements with specific agents.
Conclusions: Knowledge on cardiac manifestations in dengue is limited, and further studies are needed to establish the exact pathophysiology and role of specific agents in the prevention and treatment of cardiac complications in dengue.
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| format | Article |
| id | doaj-art-dd2e0e50f1a842ecb595d6554ef81723 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-dd2e0e50f1a842ecb595d6554ef817232025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802015-04-0190410.3855/jidc.6200Cardiac involvement in dengue infectionMitrakrishnan C Shivanthan0Mitrakrishnan R Navinan1Godwin Roger Constantine2Senaka Rajapakse3National Hospital of Sri Lanka, Regent Street, Colombo, Sri LankaNational Hospital of Sri Lanka, Regent Street, Colombo, Sri LankaFaculty of Medicine, University of Colombo, Colombo, Sri LankaFaculty of Medicine, University of Colombo, Colombo, Sri LankaIntroduction: Dengue is endemic in the tropics, and complications involving organ systems are seen with varying incidence. Methodology: We performed a systematic review. MEDLINE, EMBASE, Scopus SciVerse, Google Scholar, and LILACS were searched for papers providing information on cardiac involvement in dengue. Results: Cardiac involvement is not uncommon in dengue infection and is often transient, but may be associated with significant morbidity and even mortality. Direct viral invasion, immune mechanisms, electrolyte imbalance, derangement of intracellular calcium ion storage, lactic acidosis, and ischemia due to hypotension all play a role in myocardial dysfunction. The manifestations of cardiac involvement include clinical, electrocardiographic, echocardiographic, cardiac enzyme, and histopathologic abnormalities. Echocardiography appears to be a useful tool for detecting myocardial involvement and should be performed in patients with electrocardiographic abnormalities or hemodynamic instability. Treatment is largely supportive, though there are some anecdotal reports of improvements with specific agents. Conclusions: Knowledge on cardiac manifestations in dengue is limited, and further studies are needed to establish the exact pathophysiology and role of specific agents in the prevention and treatment of cardiac complications in dengue. https://jidc.org/index.php/journal/article/view/6200denguemyocarditispericarditisshockheartcardiac |
| spellingShingle | Mitrakrishnan C Shivanthan Mitrakrishnan R Navinan Godwin Roger Constantine Senaka Rajapakse Cardiac involvement in dengue infection Journal of Infection in Developing Countries dengue myocarditis pericarditis shock heart cardiac |
| title | Cardiac involvement in dengue infection |
| title_full | Cardiac involvement in dengue infection |
| title_fullStr | Cardiac involvement in dengue infection |
| title_full_unstemmed | Cardiac involvement in dengue infection |
| title_short | Cardiac involvement in dengue infection |
| title_sort | cardiac involvement in dengue infection |
| topic | dengue myocarditis pericarditis shock heart cardiac |
| url | https://jidc.org/index.php/journal/article/view/6200 |
| work_keys_str_mv | AT mitrakrishnancshivanthan cardiacinvolvementindengueinfection AT mitrakrishnanrnavinan cardiacinvolvementindengueinfection AT godwinrogerconstantine cardiacinvolvementindengueinfection AT senakarajapakse cardiacinvolvementindengueinfection |