Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review
Background. As people live longer, there is an increasing need for hard tissue regeneration and whole-tooth regeneration. Despite the advancements in the field of medicine, the field of regenerative dentistry is still challenging due to the complexity of dental hard tissues. Cross-disciplinary colla...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2024/9990562 |
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| author | Muhsen Alnasser Abdullah Hammad Alshammari Amna Yusuf Siddiqui Osama Shujaa Alothmani Rakhi Issrani Azhar Iqbal Osama Khattak Namdeo Prabhu |
| author_facet | Muhsen Alnasser Abdullah Hammad Alshammari Amna Yusuf Siddiqui Osama Shujaa Alothmani Rakhi Issrani Azhar Iqbal Osama Khattak Namdeo Prabhu |
| author_sort | Muhsen Alnasser |
| collection | DOAJ |
| description | Background. As people live longer, there is an increasing need for hard tissue regeneration and whole-tooth regeneration. Despite the advancements in the field of medicine, the field of regenerative dentistry is still challenging due to the complexity of dental hard tissues. Cross-disciplinary collaboration among material scientists, cellular biologists, and odontologists aimed at developing strategies and uncovering solutions related to dental tissue regeneration. Methodology. A search of the literature was done for pertinent research. Consistent with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 Statement, the electronic databases looked at were PubMed, Science Direct, Scopus, and Google Scholar, with the keyword search “hard dental tissue regeneration.” Results. Database analysis yielded a total of 476 articles. 222 duplicate articles have been removed in total. Articles that have no connection to the directed regeneration of hard dental tissue were disregarded. The review concluded with the inclusion of four studies that were relevant to our research objective. Conclusion. Current molecular signaling network investigations and novel viewpoints on cellular heterogeneity have made advancements in understanding of the kinetics of dental hard tissue regeneration possible. Here, we outline the fundamentals of stem hard dental tissue maintenance, regeneration, and repair, as well as recent advancements in the field of hard tissue regeneration. These intriguing findings help establish a framework that will eventually enable basic research findings to be utilized towards oral health-improving medicines. |
| format | Article |
| id | doaj-art-dd2cac7175d942069f8bc103e78c7794 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-dd2cac7175d942069f8bc103e78c77942025-08-20T03:25:14ZengWileyScientifica2090-908X2024-01-01202410.1155/2024/9990562Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative ReviewMuhsen Alnasser0Abdullah Hammad Alshammari1Amna Yusuf Siddiqui2Osama Shujaa Alothmani3Rakhi Issrani4Azhar Iqbal5Osama Khattak6Namdeo Prabhu7Department of Restorative Dental SciencesCollege of DentistryDepartment of EndodonticsDepartment of EndodonticsDepartment of Preventive DentistryDepartment of Restorative Dental SciencesDepartment of Restorative Dental SciencesDepartment of Oral and Maxillofacial Surgery and Diagnostic SciencesBackground. As people live longer, there is an increasing need for hard tissue regeneration and whole-tooth regeneration. Despite the advancements in the field of medicine, the field of regenerative dentistry is still challenging due to the complexity of dental hard tissues. Cross-disciplinary collaboration among material scientists, cellular biologists, and odontologists aimed at developing strategies and uncovering solutions related to dental tissue regeneration. Methodology. A search of the literature was done for pertinent research. Consistent with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 Statement, the electronic databases looked at were PubMed, Science Direct, Scopus, and Google Scholar, with the keyword search “hard dental tissue regeneration.” Results. Database analysis yielded a total of 476 articles. 222 duplicate articles have been removed in total. Articles that have no connection to the directed regeneration of hard dental tissue were disregarded. The review concluded with the inclusion of four studies that were relevant to our research objective. Conclusion. Current molecular signaling network investigations and novel viewpoints on cellular heterogeneity have made advancements in understanding of the kinetics of dental hard tissue regeneration possible. Here, we outline the fundamentals of stem hard dental tissue maintenance, regeneration, and repair, as well as recent advancements in the field of hard tissue regeneration. These intriguing findings help establish a framework that will eventually enable basic research findings to be utilized towards oral health-improving medicines.http://dx.doi.org/10.1155/2024/9990562 |
| spellingShingle | Muhsen Alnasser Abdullah Hammad Alshammari Amna Yusuf Siddiqui Osama Shujaa Alothmani Rakhi Issrani Azhar Iqbal Osama Khattak Namdeo Prabhu Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review Scientifica |
| title | Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review |
| title_full | Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review |
| title_fullStr | Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review |
| title_full_unstemmed | Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review |
| title_short | Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review |
| title_sort | tissue regeneration on rise dental hard tissue regeneration and challenges a narrative review |
| url | http://dx.doi.org/10.1155/2024/9990562 |
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