Potential role of TNFRSF12A in linking glioblastoma and alzheimer’s disease via shared tumour suppressor pathways

Potential role of TNFRSF12A in linking glioblastoma and alzheimer’s disease via shared tumour suppressor pathways

Abstract Tumor suppressor genes (TSGs) are critical regulators of cellular homeostasis and are extensively studied in cancer biology. However, their roles in neurodegenerative diseases, particularly Alzheimer’s disease (AD), remain poorly understood. Recent evidence of an inverse association between...

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Bibliographic Details
Main Authors: Ting Liu, Jingjing Pu, Sandra Theil, Yanxia Liu, Liping Jiang, Hongde Liu, Jarek Maciaczyk, Ingo G. H. Schmidt-Wolf, Jochen Walter, Amit Sharma
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Tumor suppressor genes
Alzheimer’s disease
Glioblastoma
Machine learning
scRNA-seq
Online Access:https://doi.org/10.1038/s41598-025-08000-7
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