Immune Dysregulation in Bipolar Disorder: The Role of IL-27 and EBI3
Aims: Bipolar disorder (BD) is a severe psychiatric illness characterized by alternating depressive and manic episodes. The exact cause of BD remains unclear, but inflammatory and immunological processes are believed to play a significant role in its pathophysiology. Immune system dysregulation is a...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-06-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472425101828/type/journal_article |
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| author | Golnaz Sheykhnazari Maliheh Ziaee Ezinne Ijeoma Onuba Najmeh Shahini Yaser Bagheri |
| author_facet | Golnaz Sheykhnazari Maliheh Ziaee Ezinne Ijeoma Onuba Najmeh Shahini Yaser Bagheri |
| author_sort | Golnaz Sheykhnazari |
| collection | DOAJ |
| description | Aims: Bipolar disorder (BD) is a severe psychiatric illness characterized by alternating depressive and manic episodes. The exact cause of BD remains unclear, but inflammatory and immunological processes are believed to play a significant role in its pathophysiology. Immune system dysregulation is a key factor, with pro-inflammatory markers like CRP, TNF-α, and IL-6 being elevated during mood episodes. Interleukin 27 (IL-27), which has both pro-inflammatory and anti-inflammatory properties, has not been extensively studied in BD. This study aims to investigate the levels of IL-27 and its subunit EBI3 in BD patients to better understand their role in the disease. |
| format | Article |
| id | doaj-art-dd2b9cce196c46e3b0de222c8aafba83 |
| institution | DOAJ |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-dd2b9cce196c46e3b0de222c8aafba832025-08-20T02:50:52ZengCambridge University PressBJPsych Open2056-47242025-06-0111S14S1510.1192/bjo.2025.10182Immune Dysregulation in Bipolar Disorder: The Role of IL-27 and EBI3Golnaz Sheykhnazari0Maliheh Ziaee1Ezinne Ijeoma Onuba2Najmeh Shahini3Yaser Bagheri41Golestan Research Center of Psychiatry (GRCP), Golestan University of Medical Sciences, Gorgan, Iran, Islamic Republic of2Department of Community Medicine, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran, Islamic Republic of3Erdington & Kingstanding CMHT, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, United Kingdom4Erdington & Kingstanding CMHT, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, United Kingdom 5Leicestershire Partnership NHS Trust, Leicester, United Kingdom 6Clinical Research Development Unit (CRDU), Agh ghala Hospital, Golestan University of Medical Sciences, Gorgan, Iran, Islamic Republic of7Clinical Research Development Unit (CRDU), Agh ghala Hospital,Golestan University of Medical Sciences, Gorgan, Iran, Islamic Republic of 8Immunology Department, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran, Islamic Republic ofAims: Bipolar disorder (BD) is a severe psychiatric illness characterized by alternating depressive and manic episodes. The exact cause of BD remains unclear, but inflammatory and immunological processes are believed to play a significant role in its pathophysiology. Immune system dysregulation is a key factor, with pro-inflammatory markers like CRP, TNF-α, and IL-6 being elevated during mood episodes. Interleukin 27 (IL-27), which has both pro-inflammatory and anti-inflammatory properties, has not been extensively studied in BD. This study aims to investigate the levels of IL-27 and its subunit EBI3 in BD patients to better understand their role in the disease.https://www.cambridge.org/core/product/identifier/S2056472425101828/type/journal_article |
| spellingShingle | Golnaz Sheykhnazari Maliheh Ziaee Ezinne Ijeoma Onuba Najmeh Shahini Yaser Bagheri Immune Dysregulation in Bipolar Disorder: The Role of IL-27 and EBI3 BJPsych Open |
| title | Immune Dysregulation in Bipolar Disorder: The Role of IL-27 and EBI3 |
| title_full | Immune Dysregulation in Bipolar Disorder: The Role of IL-27 and EBI3 |
| title_fullStr | Immune Dysregulation in Bipolar Disorder: The Role of IL-27 and EBI3 |
| title_full_unstemmed | Immune Dysregulation in Bipolar Disorder: The Role of IL-27 and EBI3 |
| title_short | Immune Dysregulation in Bipolar Disorder: The Role of IL-27 and EBI3 |
| title_sort | immune dysregulation in bipolar disorder the role of il 27 and ebi3 |
| url | https://www.cambridge.org/core/product/identifier/S2056472425101828/type/journal_article |
| work_keys_str_mv | AT golnazsheykhnazari immunedysregulationinbipolardisordertheroleofil27andebi3 AT malihehziaee immunedysregulationinbipolardisordertheroleofil27andebi3 AT ezinneijeomaonuba immunedysregulationinbipolardisordertheroleofil27andebi3 AT najmehshahini immunedysregulationinbipolardisordertheroleofil27andebi3 AT yaserbagheri immunedysregulationinbipolardisordertheroleofil27andebi3 |