PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer

PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer

Abstract Background Programmed cell death ligand 1 (PD-L1) expression on immune cells is correlated with the efficacy of immune checkpoint inhibitor (ICI) therapy in various types of cancer. Platelets are important components of the tumour microenvironment (TME) and are widely involved in the develo...

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Bibliographic Details
Main Authors: Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
PD-L1
Platelet
Colorectal cancer
Immune checkpoint inhibitors
Online Access:https://doi.org/10.1186/s12964-025-02034-0
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