Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol
Introduction Cognitive impairment and psychopathology caused by brain hypoxia and the traumatic impact of critical illness are common in cardiac arrest survivors and can lead to negative consequences of everyday life functioning, and further impact mental health in relatives. Most studies have dealt...
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e038633.full |
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| author | Jacob Eifer Moller Christian Hassager Selina Kikkenborg Berg Ola Ekholm Trine Bernholdt Rasmussen Mette Kirstine Wagner Sophia Armand Patrick MacDonald Fisher Gitte Moos Knudsen Dea Siggaard Stenbæk |
| author_facet | Jacob Eifer Moller Christian Hassager Selina Kikkenborg Berg Ola Ekholm Trine Bernholdt Rasmussen Mette Kirstine Wagner Sophia Armand Patrick MacDonald Fisher Gitte Moos Knudsen Dea Siggaard Stenbæk |
| author_sort | Jacob Eifer Moller |
| collection | DOAJ |
| description | Introduction Cognitive impairment and psychopathology caused by brain hypoxia and the traumatic impact of critical illness are common in cardiac arrest survivors and can lead to negative consequences of everyday life functioning, and further impact mental health in relatives. Most studies have dealt with the mere survival rate after cardiac arrest and not with long-term consequences to mental health in cardiac arrest survivors. Importantly, we face a gap in our knowledge about suitable screening tools in the early post-arrest phase for long-term risk prediction of mental health problems. This study aims to evaluate the efficacy of a novel screening procedure to predict risk of disabling cognitive impairment and psychopathology 3 months after cardiac arrest. Furthermore, the study aims to evaluate long-term prevalence of psychopathology in relatives.Methods and analyses In this multicentre prospective cohort study, out-of-hospital cardiac arrest survivors and their relatives will be recruited. The post-arrest screening includes the Montreal Cognitive Assessment (MoCA), the Hospital Anxiety and Depression Scale (HADS), the Impact of Event Scale-Revised (IES-R) and the Acute Stress Disorder Interview (ASDI) and is conducted during hospitalisation. In a subsample of the patients, functional MRI is done, and cortisol determination collected. At 3-month follow-up, the primary study outcomes for 200 survivors include the Danish Affective Verbal Learning Test-26 (VAMT-26), Delis-Kaplan Executive Function System tests (trail making, colour-word interference, word and design fluency), Rey’s Complex Figure and Letter-number sequencing subtest of Wechsler Adult Intelligence Scale-IV, HADS and IES-R. For the relatives, they include HADS and IES-R.Ethics and dissemination The study is approved by the local regional Research Ethics Committee (H-18046155) and the Danish Data Protection Agency (RH-2017-325, j.no.05961) and follows the latest version of the Declaration of Helsinki. The results will be published in peer-reviewed journals and may impact the follow-up of cardiac arrest survivors. |
| format | Article |
| id | doaj-art-dd23e7abec62483b837324f4bb074ec1 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-dd23e7abec62483b837324f4bb074ec12025-01-09T03:50:09ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2020-038633Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocolJacob Eifer Moller0Christian Hassager1Selina Kikkenborg Berg2Ola Ekholm3Trine Bernholdt Rasmussen4Mette Kirstine Wagner5Sophia Armand6Patrick MacDonald Fisher7Gitte Moos Knudsen8Dea Siggaard Stenbæk9University of Southern Denmark, Odense, DenmarkDepartment of Cardiology, Rigshospitalet, Copenhagen, Denmark5 National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade, DenmarkDepartment of Clinical Research, Nordsjællands Hospital, Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, 2200, DenmarkDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkDepartment of Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, DenmarkDepartment of Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, DenmarkDepartment of Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, DenmarkIntroduction Cognitive impairment and psychopathology caused by brain hypoxia and the traumatic impact of critical illness are common in cardiac arrest survivors and can lead to negative consequences of everyday life functioning, and further impact mental health in relatives. Most studies have dealt with the mere survival rate after cardiac arrest and not with long-term consequences to mental health in cardiac arrest survivors. Importantly, we face a gap in our knowledge about suitable screening tools in the early post-arrest phase for long-term risk prediction of mental health problems. This study aims to evaluate the efficacy of a novel screening procedure to predict risk of disabling cognitive impairment and psychopathology 3 months after cardiac arrest. Furthermore, the study aims to evaluate long-term prevalence of psychopathology in relatives.Methods and analyses In this multicentre prospective cohort study, out-of-hospital cardiac arrest survivors and their relatives will be recruited. The post-arrest screening includes the Montreal Cognitive Assessment (MoCA), the Hospital Anxiety and Depression Scale (HADS), the Impact of Event Scale-Revised (IES-R) and the Acute Stress Disorder Interview (ASDI) and is conducted during hospitalisation. In a subsample of the patients, functional MRI is done, and cortisol determination collected. At 3-month follow-up, the primary study outcomes for 200 survivors include the Danish Affective Verbal Learning Test-26 (VAMT-26), Delis-Kaplan Executive Function System tests (trail making, colour-word interference, word and design fluency), Rey’s Complex Figure and Letter-number sequencing subtest of Wechsler Adult Intelligence Scale-IV, HADS and IES-R. For the relatives, they include HADS and IES-R.Ethics and dissemination The study is approved by the local regional Research Ethics Committee (H-18046155) and the Danish Data Protection Agency (RH-2017-325, j.no.05961) and follows the latest version of the Declaration of Helsinki. The results will be published in peer-reviewed journals and may impact the follow-up of cardiac arrest survivors.https://bmjopen.bmj.com/content/10/9/e038633.full |
| spellingShingle | Jacob Eifer Moller Christian Hassager Selina Kikkenborg Berg Ola Ekholm Trine Bernholdt Rasmussen Mette Kirstine Wagner Sophia Armand Patrick MacDonald Fisher Gitte Moos Knudsen Dea Siggaard Stenbæk Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol BMJ Open |
| title | Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol |
| title_full | Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol |
| title_fullStr | Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol |
| title_full_unstemmed | Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol |
| title_short | Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol |
| title_sort | cognitive impairment and psychopathology in out of hospital cardiac arrest survivors in denmark the revival cohort study protocol |
| url | https://bmjopen.bmj.com/content/10/9/e038633.full |
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