The interval of rescue treatment does not affect the efficacy and safety of Helicobacter pylori eradication: A prospective multicenter observational study
Abstract. Background:. The effect of the interval between previous Helicobacter pylori (H. pylori) eradication and rescue treatment on therapeutic outcomes remains unknown. The aim of this study was to investigate the association between eradication rates and treatment interval durations in H. pylo...
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| Language: | English |
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Wolters Kluwer
2025-06-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003534 |
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| author | Minjuan Lin Junnan Hu Jing Liu Juan Wang Zhongxue Han Xiaohong Wang Zhenzhen Zhai Yanan Yu Wenjie Yuan Wen Zhang Zhi Wang Qingzhou Kong Boshen Lin Yuming Ding Meng Wan Wenlin Zhang Miao Duan Shuyan Zeng Yueyue Li Xiuli Zuo Yanqing Li Yuanyuan Ji |
| author_facet | Minjuan Lin Junnan Hu Jing Liu Juan Wang Zhongxue Han Xiaohong Wang Zhenzhen Zhai Yanan Yu Wenjie Yuan Wen Zhang Zhi Wang Qingzhou Kong Boshen Lin Yuming Ding Meng Wan Wenlin Zhang Miao Duan Shuyan Zeng Yueyue Li Xiuli Zuo Yanqing Li Yuanyuan Ji |
| author_sort | Minjuan Lin |
| collection | DOAJ |
| description | Abstract.
Background:. The effect of the interval between previous Helicobacter pylori (H. pylori) eradication and rescue treatment on therapeutic outcomes remains unknown. The aim of this study was to investigate the association between eradication rates and treatment interval durations in H. pylori infections.
Methods:. This prospective observational study was conducted from December 2021 to February 2023 at six tertiary hospitals in Shandong, China. We recruited patients who were positive for H. pylori infection and required rescue treatment. Demographic information, previous times of eradication therapy, last eradication therapy date, and history of antibiotic use data were collected. The patients were divided into four groups based on the rescue treatment interval length: Group A, ≥4 weeks and ≤3 months; Group B, >3 and ≤6 months; Group C, >6 and ≤12 months; and Group D, >12 months. The primary outcome was the eradication rate of H. pylori. Drug compliance and adverse events (AEs) were also assessed. Pearson’s χ2 test or Fisher’s exact test was used to compare eradication rates between groups.
Results:. A total of 670 patients were enrolled in this study. The intention-to-treat (ITT) eradication rates were 88.3% (158/179) in Group A, 89.6% (120/134) in Group B, 89.1% (123/138) in Group C, and 87.7% (192/219) in Group D. The per-protocol (PP) eradication rates were 92.9% (156/168) in Group A, 94.5% (120/127) in Group B, 94.5% (121/128) in Group C, and 93.6% (190/203) in Group D. There was no statistically significant difference in the eradication rates between groups in either the ITT (P = 0.949) or PP analysis (P = 0.921). No significant differences were observed in the incidence of AEs (P = 0.934) or drug compliance (P = 0.849) between groups.
Conclusion:. The interval duration of rescue treatment had no significant effect on H. pylori eradication rates or the incidence of AEs.
Registration:. ClinicalTrials.gov, NCT05173493. |
| format | Article |
| id | doaj-art-dd236f3510754e209fe9602d732d69be |
| institution | OA Journals |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer |
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| series | Chinese Medical Journal |
| spelling | doaj-art-dd236f3510754e209fe9602d732d69be2025-08-20T02:10:29ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-06-01138121439144610.1097/CM9.0000000000003534202506200-00006The interval of rescue treatment does not affect the efficacy and safety of Helicobacter pylori eradication: A prospective multicenter observational studyMinjuan Lin0Junnan Hu1Jing Liu2Juan Wang3Zhongxue Han4Xiaohong Wang5Zhenzhen Zhai6Yanan Yu7Wenjie Yuan8Wen Zhang9Zhi Wang10Qingzhou Kong11Boshen Lin12Yuming Ding13Meng Wan14Wenlin Zhang15Miao Duan16Shuyan Zeng17Yueyue Li18Xiuli Zuo19Yanqing Li20Yuanyuan Ji1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China4 Department of Gastroenterology, The Affiliated Taian City Centeral Hospital of Qingdao University, Taian, Shandong 271000, China5 Department of Gastroenterology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong 253000, China6 Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China7 Department of Gastroenterology, The Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, China8 Department of Gastroenterology, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, China9 Department of Internal Medicine, Maternity and Child Care Center of Dezhou, Dezhou, Shandong 253011, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China1 Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, ChinaAbstract. Background:. The effect of the interval between previous Helicobacter pylori (H. pylori) eradication and rescue treatment on therapeutic outcomes remains unknown. The aim of this study was to investigate the association between eradication rates and treatment interval durations in H. pylori infections. Methods:. This prospective observational study was conducted from December 2021 to February 2023 at six tertiary hospitals in Shandong, China. We recruited patients who were positive for H. pylori infection and required rescue treatment. Demographic information, previous times of eradication therapy, last eradication therapy date, and history of antibiotic use data were collected. The patients were divided into four groups based on the rescue treatment interval length: Group A, ≥4 weeks and ≤3 months; Group B, >3 and ≤6 months; Group C, >6 and ≤12 months; and Group D, >12 months. The primary outcome was the eradication rate of H. pylori. Drug compliance and adverse events (AEs) were also assessed. Pearson’s χ2 test or Fisher’s exact test was used to compare eradication rates between groups. Results:. A total of 670 patients were enrolled in this study. The intention-to-treat (ITT) eradication rates were 88.3% (158/179) in Group A, 89.6% (120/134) in Group B, 89.1% (123/138) in Group C, and 87.7% (192/219) in Group D. The per-protocol (PP) eradication rates were 92.9% (156/168) in Group A, 94.5% (120/127) in Group B, 94.5% (121/128) in Group C, and 93.6% (190/203) in Group D. There was no statistically significant difference in the eradication rates between groups in either the ITT (P = 0.949) or PP analysis (P = 0.921). No significant differences were observed in the incidence of AEs (P = 0.934) or drug compliance (P = 0.849) between groups. Conclusion:. The interval duration of rescue treatment had no significant effect on H. pylori eradication rates or the incidence of AEs. Registration:. ClinicalTrials.gov, NCT05173493.http://journals.lww.com/10.1097/CM9.0000000000003534 |
| spellingShingle | Minjuan Lin Junnan Hu Jing Liu Juan Wang Zhongxue Han Xiaohong Wang Zhenzhen Zhai Yanan Yu Wenjie Yuan Wen Zhang Zhi Wang Qingzhou Kong Boshen Lin Yuming Ding Meng Wan Wenlin Zhang Miao Duan Shuyan Zeng Yueyue Li Xiuli Zuo Yanqing Li Yuanyuan Ji The interval of rescue treatment does not affect the efficacy and safety of Helicobacter pylori eradication: A prospective multicenter observational study Chinese Medical Journal |
| title | The interval of rescue treatment does not affect the efficacy and safety of Helicobacter pylori eradication: A prospective multicenter observational study |
| title_full | The interval of rescue treatment does not affect the efficacy and safety of Helicobacter pylori eradication: A prospective multicenter observational study |
| title_fullStr | The interval of rescue treatment does not affect the efficacy and safety of Helicobacter pylori eradication: A prospective multicenter observational study |
| title_full_unstemmed | The interval of rescue treatment does not affect the efficacy and safety of Helicobacter pylori eradication: A prospective multicenter observational study |
| title_short | The interval of rescue treatment does not affect the efficacy and safety of Helicobacter pylori eradication: A prospective multicenter observational study |
| title_sort | interval of rescue treatment does not affect the efficacy and safety of helicobacter pylori eradication a prospective multicenter observational study |
| url | http://journals.lww.com/10.1097/CM9.0000000000003534 |
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