A roadmap towards targeted differentiation of mouse trophoblast stem cells into cell types of the feto-maternal exchange surface

A roadmap towards targeted differentiation of mouse trophoblast stem cells into cell types of the feto-maternal exchange surface

Abstract Background The characteristic constituents of the mature placenta are made up of highly specialised trophoblast cell types. Trophoblast stem cells (TSCs) possess the developmental plasticity to differentiate into all these mature placental cell types. However, TSCs are typically a heterogen...

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Bibliographic Details
Main Authors: Noura Ballasy, Bethany N. Radford, Shuhiba Mohammad, Wendy Dean, Myriam Hemberger
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Trophoblast stem cells
Drug panel
Labyrinth
Syncytiotrophoblast
Cell type specification
Directed differentiation
Online Access:https://doi.org/10.1186/s13287-025-04487-z
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