Severe sepsis in a premature neonate: protein C replacement therapy
Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
2008-08-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2457 |
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| _version_ | 1850236446980440064 |
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| author | Maria Pia De Carolis Valentina Polimeni Patrizia Papacci Serafina Lacerenza Costantino Romagnoli |
| author_facet | Maria Pia De Carolis Valentina Polimeni Patrizia Papacci Serafina Lacerenza Costantino Romagnoli |
| author_sort | Maria Pia De Carolis |
| collection | DOAJ |
| description |
Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.
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| format | Article |
| id | doaj-art-dd2185a23ced4b628df665b3f21a8a49 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2008-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-dd2185a23ced4b628df665b3f21a8a492025-08-20T02:01:57ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212008-08-01504Severe sepsis in a premature neonate: protein C replacement therapyMaria Pia De Carolis0Valentina PolimeniPatrizia PapacciSerafina LacerenzaCostantino RomagnoliDivision of Neonatal Intensive Care, Department of Pediatrics, Catholic University of Sacred Heart, Rome, Italy. Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours. https://turkjpediatr.org/article/view/2457 |
| spellingShingle | Maria Pia De Carolis Valentina Polimeni Patrizia Papacci Serafina Lacerenza Costantino Romagnoli Severe sepsis in a premature neonate: protein C replacement therapy The Turkish Journal of Pediatrics |
| title | Severe sepsis in a premature neonate: protein C replacement therapy |
| title_full | Severe sepsis in a premature neonate: protein C replacement therapy |
| title_fullStr | Severe sepsis in a premature neonate: protein C replacement therapy |
| title_full_unstemmed | Severe sepsis in a premature neonate: protein C replacement therapy |
| title_short | Severe sepsis in a premature neonate: protein C replacement therapy |
| title_sort | severe sepsis in a premature neonate protein c replacement therapy |
| url | https://turkjpediatr.org/article/view/2457 |
| work_keys_str_mv | AT mariapiadecarolis severesepsisinaprematureneonateproteincreplacementtherapy AT valentinapolimeni severesepsisinaprematureneonateproteincreplacementtherapy AT patriziapapacci severesepsisinaprematureneonateproteincreplacementtherapy AT serafinalacerenza severesepsisinaprematureneonateproteincreplacementtherapy AT costantinoromagnoli severesepsisinaprematureneonateproteincreplacementtherapy |