Smoking habit and long-term colorectal cancer incidence by exome-wide mutational and neoantigen loads: evidence based on the prospective cohort incident-tumour biobank method

Objective To test the hypothesis that the association of smoking with long-term colorectal cancer incidence may be stronger for tumours with higher mutational and neoantigen loads.Methods and analysis In the Nurses’ Health Study (1980–2012) and the Health Professionals Follow-up Study (1986–2012), o...

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Main Authors:	Li Liu, Andrew T Chan, Jeffrey A Meyerhardt, Xuehong Zhang, Mingyang Song, Molin Wang, Shuji Ogino, Charles S Fuchs, Edward L Giovannucci, Yin Cao, Mayu Higashioka, Reiko Nishihara, Yohei Masugi, Marios Giannakis, Koichiro Haruki, Mai Chan Lau, Tomotaka Ugai, Naohiko Akimoto, Jonathan A Nowak, Levi A Garraway, Tsuyoshi Hamada, Catherine J Wu, Daniel Nevo, Carino Gurjao, Satoko Ugai, Yasutoshi Takashima, Kosuke Matsuda, Nobuhiro Nakazawa, Satoshi Miyahara, Keisuke Kosumi, Sachet A Shukla
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2025-06-01
Series:	BMJ Oncology
Online Access:	https://bmjoncology.bmj.com/content/4/1/e000787.full
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Smoking habit and long-term colorectal cancer incidence by exome-wide mutational and neoantigen loads: evidence based on the prospective cohort incident-tumour biobank method

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