Hippocampus- and neocortex-specific deletion of Aeg-1 causes learning memory impairment and depression in mice

Hippocampus- and neocortex-specific deletion of Aeg-1 causes learning memory impairment and depression in mice

Abstract Astrocyte elevated gene-1 (AEG-1) has been characterized as an oncogene promoting the progression of various tumors. The role of AEG-1 in neurological diseases was highlighted by recent researches. However, the physiological function of AEG-1 remains elusive. Our study aimed to investigate...

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Main Authors: Ya-he Wang, Ning Zhou, Pan-pan Wan, Xin-tong Li, Chun-yang Yu, Jinjiang Chou, Zong-yi Feng, Lian-xiang Zhang, Juan-juan Li, Bao-cong Yu, Zhen-ning Tang, Kun-mei Liu, Le Guo
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07508-0
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