Seroprevalence, Risk Factors and Immunological Response against Hepatitis B Virus Among Students of Usmanu Danfodiyo University Sokoto, Nigeria
Study’s Excerpt • The seroprevalence of Hepatitis B Virus (HBV) among university students was investigated. • Both serological markers of HBV and immune response were assessed. • The results revealed significant associations between infection and high-risk behaviors. Full Abstract Hepatitis...
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| Format: | Article |
| Language: | English |
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Umaru Musa Yar'adua University, Katsina, Nigeria
2024-06-01
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| Series: | UMYU Journal of Microbiology Research |
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| Online Access: | https://ujmr.umyu.edu.ng/index.php/ujmr/article/view/662 |
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| author | Abusufyan Saifullahi Kabir Mohammed Kaab Salisu Sodangi Badaru Abdulkarim |
| author_facet | Abusufyan Saifullahi Kabir Mohammed Kaab Salisu Sodangi Badaru Abdulkarim |
| author_sort | Abusufyan Saifullahi |
| collection | DOAJ |
| description | Study’s Excerpt
• The seroprevalence of Hepatitis B Virus (HBV) among university students was investigated.
• Both serological markers of HBV and immune response were assessed.
• The results revealed significant associations between infection and high-risk behaviors.
Full Abstract
Hepatitis B Virus is of major public health interest as it accounts for significant mortality globally. The study aimed to determine the seroprevalence of HBV infection, the possible potential risk factors, and the immunological response among students of Usmanu Danfodiyo University, Sokoto, from December 2022 to April 2023. Structured questionnaires were used to collect sociodemographic information as well as possible risk factors related to the infection. Out of 139 study participants (10 females and 129 males screened randomly for HBsAg using a rapid HBsAg test kit, 17 (12.2%) were seropositive, and 122 (87.8%) were seronegative. The sera of the positive participants were further screened for HBeAg, anti-(HBs, HBe, and HBc) using one-step cassette diagnostic kits. Of the 17 positive samples screened, none were reactive for anti-HBs antibodies and HBeAg.; while 15 were positive anti-HBc and anti-HBe, indicating a response to natural infection. Sexual activity, unprotected sexual practices, use of already used sharp objects, and awareness of HBV infection were significantly associated (P<0.05) with the viral infection. The study indicates high endemicity in the study area. It is recommended that Nigerian Universities mandate the Hepatitis B virus vaccine for newly intake students. More awareness should be created about the dangers of unprotected sexual practice use or sharing of used sharp objects, among other possible factors. |
| format | Article |
| id | doaj-art-dd0e423d3bb049279243507e53ff21df |
| institution | Kabale University |
| issn | 2616-0668 2814-1822 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Umaru Musa Yar'adua University, Katsina, Nigeria |
| record_format | Article |
| series | UMYU Journal of Microbiology Research |
| spelling | doaj-art-dd0e423d3bb049279243507e53ff21df2024-11-27T17:02:16ZengUmaru Musa Yar'adua University, Katsina, NigeriaUMYU Journal of Microbiology Research2616-06682814-18222024-06-0157357910.47430/ujmr.2493.063662Seroprevalence, Risk Factors and Immunological Response against Hepatitis B Virus Among Students of Usmanu Danfodiyo University Sokoto, NigeriaAbusufyan Saifullahi0https://orcid.org/0009-0007-4780-4611Kabir Mohammed1Kaab Salisu Sodangi2Badaru Abdulkarim3https://orcid.org/0009-0009-3504-1797Department of Medical Laboratory, Katsina State Hospital Services Management Board, Katsina, NigeriaDepartment of Medical Microbiology, Usmanu Danfodiyo University Sokoto, Sokoto State, NigeriaDepartment of Medical Microbiology, Usmanu Danfodiyo University Sokoto, Sokoto State, NigeriaNational Institute for Pharmaceutical Research and Development (NIPRD), Idu, Abuja, NigeriaStudy’s Excerpt • The seroprevalence of Hepatitis B Virus (HBV) among university students was investigated. • Both serological markers of HBV and immune response were assessed. • The results revealed significant associations between infection and high-risk behaviors. Full Abstract Hepatitis B Virus is of major public health interest as it accounts for significant mortality globally. The study aimed to determine the seroprevalence of HBV infection, the possible potential risk factors, and the immunological response among students of Usmanu Danfodiyo University, Sokoto, from December 2022 to April 2023. Structured questionnaires were used to collect sociodemographic information as well as possible risk factors related to the infection. Out of 139 study participants (10 females and 129 males screened randomly for HBsAg using a rapid HBsAg test kit, 17 (12.2%) were seropositive, and 122 (87.8%) were seronegative. The sera of the positive participants were further screened for HBeAg, anti-(HBs, HBe, and HBc) using one-step cassette diagnostic kits. Of the 17 positive samples screened, none were reactive for anti-HBs antibodies and HBeAg.; while 15 were positive anti-HBc and anti-HBe, indicating a response to natural infection. Sexual activity, unprotected sexual practices, use of already used sharp objects, and awareness of HBV infection were significantly associated (P<0.05) with the viral infection. The study indicates high endemicity in the study area. It is recommended that Nigerian Universities mandate the Hepatitis B virus vaccine for newly intake students. More awareness should be created about the dangers of unprotected sexual practice use or sharing of used sharp objects, among other possible factors.https://ujmr.umyu.edu.ng/index.php/ujmr/article/view/662hbsaghepatitis b virusrisk factorsseroprevalenceusmanu danfodiyo university sokoto |
| spellingShingle | Abusufyan Saifullahi Kabir Mohammed Kaab Salisu Sodangi Badaru Abdulkarim Seroprevalence, Risk Factors and Immunological Response against Hepatitis B Virus Among Students of Usmanu Danfodiyo University Sokoto, Nigeria UMYU Journal of Microbiology Research hbsag hepatitis b virus risk factors seroprevalence usmanu danfodiyo university sokoto |
| title | Seroprevalence, Risk Factors and Immunological Response against Hepatitis B Virus Among Students of Usmanu Danfodiyo University Sokoto, Nigeria |
| title_full | Seroprevalence, Risk Factors and Immunological Response against Hepatitis B Virus Among Students of Usmanu Danfodiyo University Sokoto, Nigeria |
| title_fullStr | Seroprevalence, Risk Factors and Immunological Response against Hepatitis B Virus Among Students of Usmanu Danfodiyo University Sokoto, Nigeria |
| title_full_unstemmed | Seroprevalence, Risk Factors and Immunological Response against Hepatitis B Virus Among Students of Usmanu Danfodiyo University Sokoto, Nigeria |
| title_short | Seroprevalence, Risk Factors and Immunological Response against Hepatitis B Virus Among Students of Usmanu Danfodiyo University Sokoto, Nigeria |
| title_sort | seroprevalence risk factors and immunological response against hepatitis b virus among students of usmanu danfodiyo university sokoto nigeria |
| topic | hbsag hepatitis b virus risk factors seroprevalence usmanu danfodiyo university sokoto |
| url | https://ujmr.umyu.edu.ng/index.php/ujmr/article/view/662 |
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