The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's Disease

Depression is a common complication of Parkinson's disease (PD) with considerable impact on patients' quality of life. However, at present the most appropriate treatment approach is unclear. There are limited data on antidepressant medications in PD-associated depression (dPD) and those av...

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Main Authors: Andreas Charidimou, John Seamons, Caroline Selai, Anette Schrag
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.4061/2011/737523
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author Andreas Charidimou
John Seamons
Caroline Selai
Anette Schrag
author_facet Andreas Charidimou
John Seamons
Caroline Selai
Anette Schrag
author_sort Andreas Charidimou
collection DOAJ
description Depression is a common complication of Parkinson's disease (PD) with considerable impact on patients' quality of life. However, at present the most appropriate treatment approach is unclear. There are limited data on antidepressant medications in PD-associated depression (dPD) and those available suggest limited efficacy and tolerability of these drugs. Cognitive behavioural therapy (CBT) has been shown to be an effective treatment of depressive disorders. Treatment of dPD with CBT may pose particular challenges, including possible different pathophysiology, physical and mental comorbidities, and barriers to treatment through disability, which do not allow simple transfer of these results to patients with dPD. However, a number of case reports, case series, and small pilot studies suggest that this is a promising treatment for patients with PD. We here summarise the published evidence on this treatment in dPD.
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spelling doaj-art-dd073ec3c2214791b7c2cf29d830cfeb2025-08-20T03:24:26ZengWileyParkinson's Disease2042-00802011-01-01201110.4061/2011/737523737523The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's DiseaseAndreas Charidimou0John Seamons1Caroline Selai2Anette Schrag3Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London (UCL), Queen Square, London WC1N 3BG, UKInstitute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London (UCL), Queen Square, London WC1N 3BG, UKInstitute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London (UCL), Queen Square, London WC1N 3BG, UKDepartment of Clinical Neurosciences, Institute of Neurology, University College London, Royal Free Campus, London NW3 2PF, UKDepression is a common complication of Parkinson's disease (PD) with considerable impact on patients' quality of life. However, at present the most appropriate treatment approach is unclear. There are limited data on antidepressant medications in PD-associated depression (dPD) and those available suggest limited efficacy and tolerability of these drugs. Cognitive behavioural therapy (CBT) has been shown to be an effective treatment of depressive disorders. Treatment of dPD with CBT may pose particular challenges, including possible different pathophysiology, physical and mental comorbidities, and barriers to treatment through disability, which do not allow simple transfer of these results to patients with dPD. However, a number of case reports, case series, and small pilot studies suggest that this is a promising treatment for patients with PD. We here summarise the published evidence on this treatment in dPD.http://dx.doi.org/10.4061/2011/737523
spellingShingle Andreas Charidimou
John Seamons
Caroline Selai
Anette Schrag
The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's Disease
Parkinson's Disease
title The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's Disease
title_full The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's Disease
title_fullStr The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's Disease
title_full_unstemmed The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's Disease
title_short The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's Disease
title_sort role of cognitive behavioural therapy for patients with depression in parkinson s disease
url http://dx.doi.org/10.4061/2011/737523
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