Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
BackgroundHepatitis B virus (HBV) is a major global public health issue and the most common etiology of chronic liver disease (CLD). The relationship between Helicobacter pylori and HBsAg+ patients was not well investigated and has attracted much scientific and clinical interest, although the relati...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1553411/full |
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| author | Mekuriaw Belayneh Bantayehu Addis Tegegne Mulualem Lemma Zenahebezu Abay Yeshambel Belyhun |
| author_facet | Mekuriaw Belayneh Bantayehu Addis Tegegne Mulualem Lemma Zenahebezu Abay Yeshambel Belyhun |
| author_sort | Mekuriaw Belayneh |
| collection | DOAJ |
| description | BackgroundHepatitis B virus (HBV) is a major global public health issue and the most common etiology of chronic liver disease (CLD). The relationship between Helicobacter pylori and HBsAg+ patients was not well investigated and has attracted much scientific and clinical interest, although the relationship remains controversial.ObjectiveThis study aimed to assess the clinical and biochemical characteristics of HBsAg+ liver disease patients with and without H. pylori infection.MethodsFrom April 1, 2021, to March 30, 2022, a hospital-based cross-sectional study was done at the University of Gondar Comprehensive Specialized Hospital on 384 known HBsAg+ liver disease patients recruited using a convenient sampling technique. All the HBsAg+ patients were tested for fecal H. pylori antigen, and blood specimens were analyzed for ALT, AST, ALP, ALB, TP, BILT, TG, and TChol tests using an automated biochemistry analyzer. GraphPad Prism 8.02 and SPSS 25 were used for data analysis, considering a statistically significant P-value of 0.05.ResultsH. pylori co-infection was found in 153 (39.8%) of HBsAg+ study participants. ALT, AST, and total cholesterol mean levels were significantly higher in patients co-infected with H. pylori (p<0.04). Portal hypertension (47.8%), variceal bleeding (60.7%), and hepatocellular carcinoma (HCC) (57.5%) were more common (p< 0.01) in patients with HBV and H. pylori co-infection.ConclusionsALT, AST, and TChol mean levels were higher in H. pylori co-infected HBsAg+ patients. Our findings showed that H. pylori has a role in the elevation of clinical and biochemical parameters in HBsAg+ liver diseases. |
| format | Article |
| id | doaj-art-dd05286ee53e448388c52afcdfc5f85c |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-dd05286ee53e448388c52afcdfc5f85c2025-08-20T03:31:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15534111553411Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest EthiopiaMekuriaw Belayneh0Bantayehu Addis Tegegne1Mulualem Lemma2Zenahebezu Abay3Yeshambel Belyhun4Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Debremarkos University, Debre Markos, EthiopiaDepartment of Pharmacy, College of Medicine and Health Sciences, Debremarkos University, Debre Markos, EthiopiaDepartment of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaBackgroundHepatitis B virus (HBV) is a major global public health issue and the most common etiology of chronic liver disease (CLD). The relationship between Helicobacter pylori and HBsAg+ patients was not well investigated and has attracted much scientific and clinical interest, although the relationship remains controversial.ObjectiveThis study aimed to assess the clinical and biochemical characteristics of HBsAg+ liver disease patients with and without H. pylori infection.MethodsFrom April 1, 2021, to March 30, 2022, a hospital-based cross-sectional study was done at the University of Gondar Comprehensive Specialized Hospital on 384 known HBsAg+ liver disease patients recruited using a convenient sampling technique. All the HBsAg+ patients were tested for fecal H. pylori antigen, and blood specimens were analyzed for ALT, AST, ALP, ALB, TP, BILT, TG, and TChol tests using an automated biochemistry analyzer. GraphPad Prism 8.02 and SPSS 25 were used for data analysis, considering a statistically significant P-value of 0.05.ResultsH. pylori co-infection was found in 153 (39.8%) of HBsAg+ study participants. ALT, AST, and total cholesterol mean levels were significantly higher in patients co-infected with H. pylori (p<0.04). Portal hypertension (47.8%), variceal bleeding (60.7%), and hepatocellular carcinoma (HCC) (57.5%) were more common (p< 0.01) in patients with HBV and H. pylori co-infection.ConclusionsALT, AST, and TChol mean levels were higher in H. pylori co-infected HBsAg+ patients. Our findings showed that H. pylori has a role in the elevation of clinical and biochemical parameters in HBsAg+ liver diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1553411/fullHBVchronic liver diseaseH. pyloriHBV/H. pylori co-infectionEthiopia |
| spellingShingle | Mekuriaw Belayneh Bantayehu Addis Tegegne Mulualem Lemma Zenahebezu Abay Yeshambel Belyhun Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia Frontiers in Immunology HBV chronic liver disease H. pylori HBV/H. pylori co-infection Ethiopia |
| title | Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_full | Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_fullStr | Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_full_unstemmed | Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_short | Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_sort | clinical and biochemical characterization of hepatitis b surface antigen positive patients with or without helicobacter pylori co infection at the university of gondar comprehensive specialized hospital northwest ethiopia |
| topic | HBV chronic liver disease H. pylori HBV/H. pylori co-infection Ethiopia |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1553411/full |
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