A new index for evaluating the antioxidant capacity of hemodialysis membranes using Fenton’s reagent
Abstract Background Hemodialysis and hemodiafiltration therapy involve supplying large amounts of blood and dialysis fluid to a hemodialyzer. Although the biocompatibility of dialysis membranes has improved recently, a standard evaluation method has not been established. In this study, we aimed to e...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Renal Replacement Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41100-024-00593-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850255816060305408 |
|---|---|
| author | Yoshihiro Tange Junichi Michikoshi Tadashi Tomo |
| author_facet | Yoshihiro Tange Junichi Michikoshi Tadashi Tomo |
| author_sort | Yoshihiro Tange |
| collection | DOAJ |
| description | Abstract Background Hemodialysis and hemodiafiltration therapy involve supplying large amounts of blood and dialysis fluid to a hemodialyzer. Although the biocompatibility of dialysis membranes has improved recently, a standard evaluation method has not been established. In this study, we aimed to establish a standard method for evaluating the antioxidant capacity of hemodialysis membranes. Methods We used Fenton’s reagent to evaluate the antioxidant capacity of the spent washing solution for dialyzers and hemodialysis membranes. The dialysis membrane materials used for the test were conventional or vitamin E-coated polysulfone. Results The luminescence in the first 200 mL of the spent washing solutions was significantly lower than that of the control solution, for both the polysulfone and vitamin E-coated polysulfone membranes, because the dialyzer filling solution contained sodium metabisulfite as an antioxidant. Compared with the conventional polysulfone membrane, the vitamin E-coated membrane maintained its antioxidant capacity index after exposure to Fenton’s reagent. Vitamin E-coated membranes inhibited oxidation by Fenton’s reagent 5.5% more than polysulfone membranes. Conclusions Exposure to Fenton’s reagent can serve as a standard in vitro index to evaluate the antioxidant capacity of dialysis membrane materials that require large quantities of solution. |
| format | Article |
| id | doaj-art-dd02a0c6be264d988d31f00e19c93a68 |
| institution | OA Journals |
| issn | 2059-1381 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Renal Replacement Therapy |
| spelling | doaj-art-dd02a0c6be264d988d31f00e19c93a682025-08-20T01:56:46ZengBMCRenal Replacement Therapy2059-13812024-12-011011710.1186/s41100-024-00593-5A new index for evaluating the antioxidant capacity of hemodialysis membranes using Fenton’s reagentYoshihiro Tange0Junichi Michikoshi1Tadashi Tomo2Department of Advanced Medical Sciences, Faculty of Medicine, Oita UniversityDepartment of Advanced Medical Sciences, Faculty of Medicine, Oita UniversityDepartment of Advanced Medical Sciences, Faculty of Medicine, Oita UniversityAbstract Background Hemodialysis and hemodiafiltration therapy involve supplying large amounts of blood and dialysis fluid to a hemodialyzer. Although the biocompatibility of dialysis membranes has improved recently, a standard evaluation method has not been established. In this study, we aimed to establish a standard method for evaluating the antioxidant capacity of hemodialysis membranes. Methods We used Fenton’s reagent to evaluate the antioxidant capacity of the spent washing solution for dialyzers and hemodialysis membranes. The dialysis membrane materials used for the test were conventional or vitamin E-coated polysulfone. Results The luminescence in the first 200 mL of the spent washing solutions was significantly lower than that of the control solution, for both the polysulfone and vitamin E-coated polysulfone membranes, because the dialyzer filling solution contained sodium metabisulfite as an antioxidant. Compared with the conventional polysulfone membrane, the vitamin E-coated membrane maintained its antioxidant capacity index after exposure to Fenton’s reagent. Vitamin E-coated membranes inhibited oxidation by Fenton’s reagent 5.5% more than polysulfone membranes. Conclusions Exposure to Fenton’s reagent can serve as a standard in vitro index to evaluate the antioxidant capacity of dialysis membrane materials that require large quantities of solution.https://doi.org/10.1186/s41100-024-00593-5Dialysis membraneVitamin E-coated polysulfone membranesPolysulfone membranesFenton’s reagentAntioxidant capacity |
| spellingShingle | Yoshihiro Tange Junichi Michikoshi Tadashi Tomo A new index for evaluating the antioxidant capacity of hemodialysis membranes using Fenton’s reagent Renal Replacement Therapy Dialysis membrane Vitamin E-coated polysulfone membranes Polysulfone membranes Fenton’s reagent Antioxidant capacity |
| title | A new index for evaluating the antioxidant capacity of hemodialysis membranes using Fenton’s reagent |
| title_full | A new index for evaluating the antioxidant capacity of hemodialysis membranes using Fenton’s reagent |
| title_fullStr | A new index for evaluating the antioxidant capacity of hemodialysis membranes using Fenton’s reagent |
| title_full_unstemmed | A new index for evaluating the antioxidant capacity of hemodialysis membranes using Fenton’s reagent |
| title_short | A new index for evaluating the antioxidant capacity of hemodialysis membranes using Fenton’s reagent |
| title_sort | new index for evaluating the antioxidant capacity of hemodialysis membranes using fenton s reagent |
| topic | Dialysis membrane Vitamin E-coated polysulfone membranes Polysulfone membranes Fenton’s reagent Antioxidant capacity |
| url | https://doi.org/10.1186/s41100-024-00593-5 |
| work_keys_str_mv | AT yoshihirotange anewindexforevaluatingtheantioxidantcapacityofhemodialysismembranesusingfentonsreagent AT junichimichikoshi anewindexforevaluatingtheantioxidantcapacityofhemodialysismembranesusingfentonsreagent AT tadashitomo anewindexforevaluatingtheantioxidantcapacityofhemodialysismembranesusingfentonsreagent AT yoshihirotange newindexforevaluatingtheantioxidantcapacityofhemodialysismembranesusingfentonsreagent AT junichimichikoshi newindexforevaluatingtheantioxidantcapacityofhemodialysismembranesusingfentonsreagent AT tadashitomo newindexforevaluatingtheantioxidantcapacityofhemodialysismembranesusingfentonsreagent |