Progression of IgM Monoclonal Gammopathy of Renal Significance (MGRS) to Symptomatic Waldenström Macroglobulinemia: A Case Report
ABSTRACT Background Monoclonal gammopathy of renal significance (MGRS) is characterized as renal impairment caused by monoclonal protein but does not fulfill the criteria for specific hematologic malignancies. Most MGRS cases involve IgG, IgA, or light chains, but IgM‐MGRS remains poorly understood....
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Wiley
2025-07-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70281 |
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| author | Kenichi Ito Hiroaki Shimoyamada Kazuhiko Hirano Naohiro Sekiguchi |
| author_facet | Kenichi Ito Hiroaki Shimoyamada Kazuhiko Hirano Naohiro Sekiguchi |
| author_sort | Kenichi Ito |
| collection | DOAJ |
| description | ABSTRACT Background Monoclonal gammopathy of renal significance (MGRS) is characterized as renal impairment caused by monoclonal protein but does not fulfill the criteria for specific hematologic malignancies. Most MGRS cases involve IgG, IgA, or light chains, but IgM‐MGRS remains poorly understood. Case We present a 74‐year‐old woman with IgM‐κ monoclonal proteinuria who initially declined further evaluation. Later, anemia was identified, and a systemic work‐up revealed monoclonal immunoglobulin deposition disease in the kidney and symptomatic Waldenström macroglobulinemia. Treatment with a Bruton's tyrosine kinase inhibitor, namely tirabrutinib, rapidly resolved both proteinuria and anemia. Conclusion This case highlights the importance of early renal biopsy and prompt intervention in suspected IgM‐MGRS. |
| format | Article |
| id | doaj-art-dcfdbf4bba9946f9ba87b965b85d12bd |
| institution | DOAJ |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-dcfdbf4bba9946f9ba87b965b85d12bd2025-08-20T02:48:42ZengWileyCancer Reports2573-83482025-07-0187n/an/a10.1002/cnr2.70281Progression of IgM Monoclonal Gammopathy of Renal Significance (MGRS) to Symptomatic Waldenström Macroglobulinemia: A Case ReportKenichi Ito0Hiroaki Shimoyamada1Kazuhiko Hirano2Naohiro Sekiguchi3Hematology Division National Hospital Organization Disaster Medical Center Tokyo JapanPathology Division Dokkyo Medical University Saitama Medical Center Saitama JapanLaboratory and Pathology Division National Hospital Organization Disaster Medical Center Tokyo JapanHematology Division National Hospital Organization Disaster Medical Center Tokyo JapanABSTRACT Background Monoclonal gammopathy of renal significance (MGRS) is characterized as renal impairment caused by monoclonal protein but does not fulfill the criteria for specific hematologic malignancies. Most MGRS cases involve IgG, IgA, or light chains, but IgM‐MGRS remains poorly understood. Case We present a 74‐year‐old woman with IgM‐κ monoclonal proteinuria who initially declined further evaluation. Later, anemia was identified, and a systemic work‐up revealed monoclonal immunoglobulin deposition disease in the kidney and symptomatic Waldenström macroglobulinemia. Treatment with a Bruton's tyrosine kinase inhibitor, namely tirabrutinib, rapidly resolved both proteinuria and anemia. Conclusion This case highlights the importance of early renal biopsy and prompt intervention in suspected IgM‐MGRS.https://doi.org/10.1002/cnr2.70281monoclonal gammopathy of renal significancemonoclonal immunoglobulin deposition diseaseTirabrutinibWaldenstrom macroglobulinemia |
| spellingShingle | Kenichi Ito Hiroaki Shimoyamada Kazuhiko Hirano Naohiro Sekiguchi Progression of IgM Monoclonal Gammopathy of Renal Significance (MGRS) to Symptomatic Waldenström Macroglobulinemia: A Case Report Cancer Reports monoclonal gammopathy of renal significance monoclonal immunoglobulin deposition disease Tirabrutinib Waldenstrom macroglobulinemia |
| title | Progression of IgM Monoclonal Gammopathy of Renal Significance (MGRS) to Symptomatic Waldenström Macroglobulinemia: A Case Report |
| title_full | Progression of IgM Monoclonal Gammopathy of Renal Significance (MGRS) to Symptomatic Waldenström Macroglobulinemia: A Case Report |
| title_fullStr | Progression of IgM Monoclonal Gammopathy of Renal Significance (MGRS) to Symptomatic Waldenström Macroglobulinemia: A Case Report |
| title_full_unstemmed | Progression of IgM Monoclonal Gammopathy of Renal Significance (MGRS) to Symptomatic Waldenström Macroglobulinemia: A Case Report |
| title_short | Progression of IgM Monoclonal Gammopathy of Renal Significance (MGRS) to Symptomatic Waldenström Macroglobulinemia: A Case Report |
| title_sort | progression of igm monoclonal gammopathy of renal significance mgrs to symptomatic waldenstrom macroglobulinemia a case report |
| topic | monoclonal gammopathy of renal significance monoclonal immunoglobulin deposition disease Tirabrutinib Waldenstrom macroglobulinemia |
| url | https://doi.org/10.1002/cnr2.70281 |
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