In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist
Solid rationales are still present for the identification of synthetic ligands to simultaneously target multiple PPAR subtypes for the treatment of T2DM. The purpose of this study was to characterize the in vitro and in vivo differential effects of chiglitazar, a non-TZD type of PPAR pan-agonist cur...
Saved in:
| Main Authors: | B. K. He, Z. Q. Ning, Z. B. Li, S. Shan, D. S. Pan, B. C. B. Ko, P. P. Li, Z. F. Shen, G. F. Dou, B. L. Zhang, X. P. Lu, Y. Gao |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/546548 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγ
by: De-Si Pan, et al.
Published: (2017-01-01) -
Chiglitazar diminishes the warburg effect through PPARγ/mTOR/PKM2 and increases the sensitivity of imatinib in chronic myeloid leukemia
by: Hongpeng Duan, et al.
Published: (2024-12-01) -
Administration of chiglitazar reverses chronic stress-induced depressive-like symptoms in mice via activation of hippocampal PPARα and BDNF
by: Jiu-Jian Zhou, et al.
Published: (2025-04-01) -
Chiglitazar ameliorates dehydroepiandrosterone-induced polycystic ovary syndrome in rats
by: Fuzhen Zhao, et al.
Published: (2024-11-01) -
In silico and in vitro investigations reveal pan-PPAR agonist activity and anti-NAFLD efficacy of polydatin by modulating hepatic lipid-energy metabolism
by: Sumit Kumar Mandal, et al.
Published: (2025-07-01)