Dynamics of the blood plasma proteome during hyperacute HIV-1 infection
Abstract The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collec...
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54848-0 |
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| author | Jamirah Nazziwa Eva Freyhult Mun-Gwan Hong Emil Johansson Filip Årman Jonathan Hare Kamini Gounder Melinda Rezeli Tirthankar Mohanty Sven Kjellström Anatoli Kamali Etienne Karita William Kilembe Matt A. Price Pontiano Kaleebu Susan Allen Eric Hunter Thumbi Ndung’u Jill Gilmour Sarah L. Rowland-Jones Eduard Sanders Amin S. Hassan Joakim Esbjörnsson |
| author_facet | Jamirah Nazziwa Eva Freyhult Mun-Gwan Hong Emil Johansson Filip Årman Jonathan Hare Kamini Gounder Melinda Rezeli Tirthankar Mohanty Sven Kjellström Anatoli Kamali Etienne Karita William Kilembe Matt A. Price Pontiano Kaleebu Susan Allen Eric Hunter Thumbi Ndung’u Jill Gilmour Sarah L. Rowland-Jones Eduard Sanders Amin S. Hassan Joakim Esbjörnsson |
| author_sort | Jamirah Nazziwa |
| collection | DOAJ |
| description | Abstract The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levels with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load. |
| format | Article |
| id | doaj-art-dcf2b3c1e62f45ceb50912141a3bb216 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-dcf2b3c1e62f45ceb50912141a3bb2162025-08-20T02:20:48ZengNature PortfolioNature Communications2041-17232024-12-0115111410.1038/s41467-024-54848-0Dynamics of the blood plasma proteome during hyperacute HIV-1 infectionJamirah Nazziwa0Eva Freyhult1Mun-Gwan Hong2Emil Johansson3Filip Årman4Jonathan Hare5Kamini Gounder6Melinda Rezeli7Tirthankar Mohanty8Sven Kjellström9Anatoli Kamali10Etienne Karita11William Kilembe12Matt A. Price13Pontiano Kaleebu14Susan Allen15Eric Hunter16Thumbi Ndung’u17Jill Gilmour18Sarah L. Rowland-Jones19Eduard Sanders20Amin S. Hassan21Joakim Esbjörnsson22Department of Translational Medicine, Lund UniversityNational Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala UniversityNational Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm UniversityDepartment of Translational Medicine, Lund UniversityBioMS−Swedish National Infrastructure for Biological Mass Spectrometry, Lund UniversityIAVI Human Immunology Laboratory, Imperial CollegeAfrica Health Research InstituteBioMS−Swedish National Infrastructure for Biological Mass Spectrometry, Lund UniversityDivision of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund UniversityBioMS−Swedish National Infrastructure for Biological Mass Spectrometry, Lund UniversityIAVICenter for Family Health ResearchCenter for Family Health ResearchIAVIUganda Research Unit, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical MedicineCenter for Family Health ResearchCenter for Family Health ResearchAfrica Health Research InstituteDepartment of Infectious Diseases, Infection and Immunity, Faculty of Medicine, Imperial CollegeNuffield Department of Medicine, University of OxfordSir William Dunn School of Pathology, University of OxfordDepartment of Translational Medicine, Lund UniversityDepartment of Translational Medicine, Lund UniversityAbstract The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levels with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load.https://doi.org/10.1038/s41467-024-54848-0 |
| spellingShingle | Jamirah Nazziwa Eva Freyhult Mun-Gwan Hong Emil Johansson Filip Årman Jonathan Hare Kamini Gounder Melinda Rezeli Tirthankar Mohanty Sven Kjellström Anatoli Kamali Etienne Karita William Kilembe Matt A. Price Pontiano Kaleebu Susan Allen Eric Hunter Thumbi Ndung’u Jill Gilmour Sarah L. Rowland-Jones Eduard Sanders Amin S. Hassan Joakim Esbjörnsson Dynamics of the blood plasma proteome during hyperacute HIV-1 infection Nature Communications |
| title | Dynamics of the blood plasma proteome during hyperacute HIV-1 infection |
| title_full | Dynamics of the blood plasma proteome during hyperacute HIV-1 infection |
| title_fullStr | Dynamics of the blood plasma proteome during hyperacute HIV-1 infection |
| title_full_unstemmed | Dynamics of the blood plasma proteome during hyperacute HIV-1 infection |
| title_short | Dynamics of the blood plasma proteome during hyperacute HIV-1 infection |
| title_sort | dynamics of the blood plasma proteome during hyperacute hiv 1 infection |
| url | https://doi.org/10.1038/s41467-024-54848-0 |
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