Synthesis, physical-chemical properties and further transformation of 5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dyhydro-3Н-1,2,4-triazole-3-thiones

Synthesis, physical-chemical properties and further transformation of 5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dyhydro-3Н-1,2,4-triazole-3-thiones

The aim of this work was the synthesis of new highly effective and low-toxic substances in a series of 5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R1-2,4-dyhydro-3Н-1,2,4-triazole-3-thiones and its derivatives, and also establishment of physical-chemical properties of all synthesized compounds, as...

Full description

Saved in:

Bibliographic Details
Main Author:	T. M. Kaplaushenko
Format:	Article
Language:	English
Published:	Zaporizhzhia State Medical and Pharmaceutical University 2016-08-01
Series:	Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:	1 2 4-triazole Synthesis Physical-Chemical Properties
Online Access:	http://pharmed.zsmu.edu.ua/article/view/71083/67972
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis and physical-chemical properties of 3-alkylthio-5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dihydro-3H-1,2,4-triazoles
by: T. M. Kaplaushenko, et al.
Published: (2016-06-01)

The study of analgesic effect of 5-(furan-2-yl, 2-methylfuran-3-yl)-4-amino-1,2,4-triazole-3-thion derivatives
by: D. M. Danilchenko
Published: (2018-10-01)

Synthesis methods of 1,2,4-triazole-3-thiones: review
by: Yu. S. Frolova, et al.
Published: (2024-06-01)

Synthesis and physical-chemical properties of 6-(5-(1Н-tetrazole-1-ylmethyl)-4-R-1,2,4-triazole-3-ylthio)pyridin-3-amines and 6-((5-(1Н-tetrazole-1-yl)methil-4-R-1,2,4-triazole-3-ylthio)pyridin-3-yl)-(alk,ar,heter)ylmethanimines
by: Yu. S. Hulina, et al.
Published: (2017-02-01)

Effect of 4-benzylidenamino-5-phenyl-4Н-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4Н-1,2,4-triazole-3-ylthio)acetic acid on central component of nociceptive system
by: Ye. S. Pruhlo
Published: (2016-08-01)

ACUTE TOXICITYOF 4-AMINO-5-(2-, 3-, 4-NITROPHENYL)-1,2,4-TRIAZOLE-3-THIONES AND ITS DERIVATIVES
by: М. O. Shcherbak, et al.
Published: (2014-12-01)

In silico study of new bis-3R, 4R′-5-(((1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thione derivatives
by: Ye. O. Karpun, et al.
Published: (2019-12-01)

Establishment of diuretic activity indicators for (3-thio-4-R-4-H-1,2,4-triazole-5-yl)(phenyl)methanols and their derivatives
by: A. M. Rud, et al.
Published: (2018-08-01)

Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones
by: Ye. S. Pruglo, et al.
Published: (2015-12-01)

Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives
by: Yu. G. Samelyuk, et al.
Published: (2015-12-01)

Synthesis, physical and chemical properties of esters of 2-((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)ethanoic and 3-(((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)methyl)benzoic acids
by: А. M. Rud, et al.
Published: (2017-12-01)

Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines
by: Ye. O. Karpun, et al.
Published: (2020-11-01)

Actoprotective activity of 2-(4-r-3-(thiophen-2-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid
by: V. O. Salionov, et al.
Published: (2017-03-01)

Acute toxicity of 5-(furan-2-yl, 2-metylfuran-3-yl)-4-amino-1,2,4-triazole-3-thiol alkyl derivatives
by: D. M. Danilchenko, et al.
Published: (2017-09-01)

Creation, study of physical and chemical properties of 2-((4-R-5-phenethyl-4H-1,2,4-triazole-3-yl)thio)ethanоic(propanоic, benzoic)acids and salts of 2-((4-R-5-phenethyl-4H-1,2,4-triazole-3-yl)thio)ethanoic acid
by: T. V. Ihnatova, et al.
Published: (2019-07-01)

Development and validation of HPLC-DAD method of determination piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetate in 1 % solution
by: B. O. Varynskyi, et al.
Published: (2017-12-01)

Diuretic activity of 2-((4-amino-5-R-4H-1,2,4-triazole-3-yl)thio)acetohydrazides
by: D. M. Danilchenko, et al.
Published: (2017-08-01)

The development and validation of HPLC-DMD method for intermediate products impurities determination of morpholinium 2-((4-(2-methoxyphenyl)-5-(pyridine-4-yl)-4H-1,2,4-triazole-3-yl)thio)acetate in bulk drug
by: B. O. Varynskyi, et al.
Published: (2017-06-01)

Synthesis and physical-chemical properties of 2-(5-(1Н-tetrazol-1-ylmethyl)-4-R-4Н-1,2,4-triazol-3-yltio)-acetic (propanoic), 2-, 4-(5-(1Н-tetrazol-1- ylmethyl)-4-phenyl-4Н-1,2,4-triazol-3- yltiometil)-benzoic acids and their salts
by: Y. S. Hulina, et al.
Published: (2016-08-01)

Synthesis and properties of 5-(((5-amino-1,3,4-thiadiazole-2-yl)thio)methyl)-4-phenyl-1,2,4-triazole-3-thione and its some S-derivatives
by: A. S. Hotsulia, et al.
Published: (2020-08-01)

Computer prediction of acute toxicity of thioderivatives of 3,5-bis(5-mercapto-4-R-4H-1,2,4-triazol-3-yl)phenol
by: K. K. Isaicheva, et al.
Published: (2024-11-01)

Synthesis, physical and chemical properties, antihypoxic activity of some 5-[((5-(adamantane-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl]-N-R1-1,3,4-thiadiazole-2-amines and 5-[((5-(adamantane-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl]-4-R1-4H-1,2,4-t
by: V. M. Odyntsova, et al.
Published: (2018-03-01)

Synthesis and transformation in the series of 2-((5-(2,4- and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)acetic acids
by: D. V. Dovbnia, et al.
Published: (2021-03-01)

Synthesis and antituberculosis activity of N'-(2-(5-((theophylline-7'-yl)methyl)-4-R-4Н-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazides
by: A. S. Gotsulya, et al.
Published: (2018-08-01)

The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols
by: Ye. O. Karpun, et al.
Published: (2022-08-01)

Synthesis, physical-chemical properties of 2-((5-(adamantan-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)acetic acid esters
by: V. M. Odyntsova
Published: (2017-04-01)

Synthesis, physical-chemical properties and the study of anti-hypoxemic activity of 5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-thion alkylderivatives
by: V. M. Odyntsova, et al.
Published: (2015-04-01)

Antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives
by: D. M. Danilchenko, et al.
Published: (2017-02-01)

Determination of the isotonicity 1 % solution of sodium 2-((4-amino-5-thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetate
by: D. L. Usenko, et al.
Published: (2024-02-01)

Analgesic activity of 4-amino-5-methyl-4H-1,2,4-triazol-3-thiones
by: T. V. Kravchenko, et al.
Published: (2018-10-01)

Synthesis, physical and chemical properties of 2-((5-(hydroxy(phenyl)methyl)-4R-4H-1,2,4-triazole-3-yl)thio)acetic acids and its salts
by: A. M. Rud, et al.
Published: (2018-02-01)

The study of morpholinium 2-[5-(pyridin-4yl)-1,2,4-triazol-3-ylthio]acetate effect on prevention of stressful conditions
by: I. V. Bushueva, et al.
Published: (2014-08-01)

Actoprotective properties of 7'-((3-thio-4-methyl-4H-1,2,4-triazole-5-yl)methyl)theophylline derivatives
by: A. S. Gotsulya
Published: (2016-06-01)

Analgesic activity of the salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid
by: V. M. Odintsova
Published: (2016-04-01)

EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL
by: Mazin N. Mousa
Published: (2012-06-01)

Actoprotective activity research of 2-((5-(2-bromophenyl)-4-substituted-4H-1,2,4-triazole-3-yl)thio)acetates
by: A. A. Safonov, et al.
Published: (2020-09-01)

Synthesis and physical-chemical properties of 2-((4-R-3-(morpholinomethylen)-4H-1,2,4-triazole-5yl)thio)acetic acid
by: R. О. Shcherbyna, et al.
Published: (2014-12-01)

Research of the antimicrobial and antifungal activity of 7-((3-thio-4-R-4H-1,2,4-triazoles-3-yl)methyl)theophylline S-derivatives
by: A. S. Gotsulya Ye. G. Knysh, et al.
Published: (2015-08-01)

Synthesis and properties of S-derivatives of 4-amino-5-(5-methylpyrazol-3-yl)-1,2,4-triazole-3-thiol
by: S. O. Fedotov, et al.
Published: (2021-12-01)

DFT analysis of the [3 + 2] heterocyclization reaction of ((1,2,4-triazole(1,3,4-oxadiazole)-3(2)-yl)methyl)thiopyrimidines
by: Yu. V. Karpenko
Published: (2025-03-01)