Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity

Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity

BackgroundUnderstanding genetic underpinnings of immune-mediated inflammatory diseases is crucial to improve treatments. Single-cell RNA sequencing (scRNA-seq) identifies cell states expanded in disease, but often overlooks genetic causality due to cost and small genotyping cohorts. Conversely, larg...

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Bibliographic Details
Main Authors: Hope A. Townsend, Kaylee J. Rosenberger, Lauren A. Vanderlinden, Jun Inamo, Fan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
scRNA-seq
GWAS
SNP-gene linking
autoimmune diseases
benchmarking
omics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1454263/full
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