Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus)

Early and accurate diagnosis of pulmonary tuberculosis (TB) is key to effective outbreak management, and in humans thoracic radiography is used extensively for screening purposes. In wildlife TB radiography is a relatively accessible diagnostic tool, particularly in under-resourced settings, however...

Full description

Saved in:
Bibliographic Details
Main Authors: Kirsty Officer, Natalie Webster, Alana J. Rosenblatt, Phorn Sorphea, Kris Warren, Bethany Jackson
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Veterinary Science
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2024.1460140/full
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1841558801191272448
author Kirsty Officer
Kirsty Officer
Natalie Webster
Alana J. Rosenblatt
Phorn Sorphea
Kris Warren
Kris Warren
Bethany Jackson
Bethany Jackson
author_facet Kirsty Officer
Kirsty Officer
Natalie Webster
Alana J. Rosenblatt
Phorn Sorphea
Kris Warren
Kris Warren
Bethany Jackson
Bethany Jackson
author_sort Kirsty Officer
collection DOAJ
description Early and accurate diagnosis of pulmonary tuberculosis (TB) is key to effective outbreak management, and in humans thoracic radiography is used extensively for screening purposes. In wildlife TB radiography is a relatively accessible diagnostic tool, particularly in under-resourced settings, however its use is limited by body size. Sun bears are susceptible to human-associated TB, and their small body size makes thoracic radiography feasible. However, there are no established guidelines on normal thoracic radiographs or radiographic manifestations of TB in this species. We provide a first description of thoracic radiographs from healthy and TB affected sun bears at a bear rescue sanctuary, including correlation with postmortem results for a subset of bears. Findings of two veterinary radiologists, blinded to clinical information, revealed high agreement on broad categorization of radiographic studies as normal, abnormal, or needing correlation with further information. Agreement was lower for the presence of specific lung patterns, reflecting inherent subjectivity when classifying these features. Very few studies were identified as definitively normal, however definitively abnormal studies were significantly associated with TB cases. Diffuse bronchial and/or bronchointerstitital lung patterns were commonly reported, with a high proportion needing correlation with age and/or clinical signs to further interpret. Interstitial, interstitial-to-alveolar, alveolar and nodular lung patterns, along with radiographic signs of lymphadenomegaly and pleural fluid, were almost exclusively found in TB cases, however the sensitivity of the presence of any of these changes for detecting TB was below 70%. Radiographic reporting of thoracic lymph node enlargement detected at postmortem was low (4/17; 23%), and aortic outflow tract dilation and positional atelectasis were differential diagnoses for radiographic changes that could also represent TB. Together these findings demonstrate the importance of developing species-specific criteria for interpretation, to differentiate between common findings and manifestations of TB, and to highlight areas where radiographic techniques can be optimized to assist this. Given TB remains a global health challenge in humans and other animals (wild or domestic), and detection is key to control, we recommend development of standardized approaches to radiographic studies and their interpretation to bolster diagnostic pathways for detecting TB in sun bears, and other novel or understudied hosts.
format Article
id doaj-art-dce655a0636d4b7393529e55efbdab79
institution Kabale University
issn 2297-1769
language English
publishDate 2025-01-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Veterinary Science
spelling doaj-art-dce655a0636d4b7393529e55efbdab792025-01-06T06:58:59ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.14601401460140Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus)Kirsty Officer0Kirsty Officer1Natalie Webster2Alana J. Rosenblatt3Phorn Sorphea4Kris Warren5Kris Warren6Bethany Jackson7Bethany Jackson8School of Veterinary Medicine, Murdoch University, Perth, WA, AustraliaFree the Bears, Phnom Penh, CambodiaDiagnostic Imaging Department, Melbourne Animal Specialist Hospital, Melbourne, VIC, AustraliaSchool of Veterinary Science, The University of Queensland, Gatton, QLD, AustraliaFree the Bears, Phnom Penh, CambodiaSchool of Veterinary Medicine, Murdoch University, Perth, WA, AustraliaCentre for Terrestrial Ecosystem Science and Sustainability, Harry Butler Institute, Murdoch University, Perth, WA, AustraliaSchool of Veterinary Medicine, Murdoch University, Perth, WA, AustraliaCentre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Perth, WA, AustraliaEarly and accurate diagnosis of pulmonary tuberculosis (TB) is key to effective outbreak management, and in humans thoracic radiography is used extensively for screening purposes. In wildlife TB radiography is a relatively accessible diagnostic tool, particularly in under-resourced settings, however its use is limited by body size. Sun bears are susceptible to human-associated TB, and their small body size makes thoracic radiography feasible. However, there are no established guidelines on normal thoracic radiographs or radiographic manifestations of TB in this species. We provide a first description of thoracic radiographs from healthy and TB affected sun bears at a bear rescue sanctuary, including correlation with postmortem results for a subset of bears. Findings of two veterinary radiologists, blinded to clinical information, revealed high agreement on broad categorization of radiographic studies as normal, abnormal, or needing correlation with further information. Agreement was lower for the presence of specific lung patterns, reflecting inherent subjectivity when classifying these features. Very few studies were identified as definitively normal, however definitively abnormal studies were significantly associated with TB cases. Diffuse bronchial and/or bronchointerstitital lung patterns were commonly reported, with a high proportion needing correlation with age and/or clinical signs to further interpret. Interstitial, interstitial-to-alveolar, alveolar and nodular lung patterns, along with radiographic signs of lymphadenomegaly and pleural fluid, were almost exclusively found in TB cases, however the sensitivity of the presence of any of these changes for detecting TB was below 70%. Radiographic reporting of thoracic lymph node enlargement detected at postmortem was low (4/17; 23%), and aortic outflow tract dilation and positional atelectasis were differential diagnoses for radiographic changes that could also represent TB. Together these findings demonstrate the importance of developing species-specific criteria for interpretation, to differentiate between common findings and manifestations of TB, and to highlight areas where radiographic techniques can be optimized to assist this. Given TB remains a global health challenge in humans and other animals (wild or domestic), and detection is key to control, we recommend development of standardized approaches to radiographic studies and their interpretation to bolster diagnostic pathways for detecting TB in sun bears, and other novel or understudied hosts.https://www.frontiersin.org/articles/10.3389/fvets.2024.1460140/fullsun bearHelarctos malayanustuberculosisthoracic radiologyrescue centerimaging
spellingShingle Kirsty Officer
Kirsty Officer
Natalie Webster
Alana J. Rosenblatt
Phorn Sorphea
Kris Warren
Kris Warren
Bethany Jackson
Bethany Jackson
Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus)
Frontiers in Veterinary Science
sun bear
Helarctos malayanus
tuberculosis
thoracic radiology
rescue center
imaging
title Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus)
title_full Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus)
title_fullStr Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus)
title_full_unstemmed Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus)
title_short Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus)
title_sort comparative thoracic radiography in healthy and tuberculosis positive sun bears helarctos malayanus
topic sun bear
Helarctos malayanus
tuberculosis
thoracic radiology
rescue center
imaging
url https://www.frontiersin.org/articles/10.3389/fvets.2024.1460140/full
work_keys_str_mv AT kirstyofficer comparativethoracicradiographyinhealthyandtuberculosispositivesunbearshelarctosmalayanus
AT kirstyofficer comparativethoracicradiographyinhealthyandtuberculosispositivesunbearshelarctosmalayanus
AT nataliewebster comparativethoracicradiographyinhealthyandtuberculosispositivesunbearshelarctosmalayanus
AT alanajrosenblatt comparativethoracicradiographyinhealthyandtuberculosispositivesunbearshelarctosmalayanus
AT phornsorphea comparativethoracicradiographyinhealthyandtuberculosispositivesunbearshelarctosmalayanus
AT kriswarren comparativethoracicradiographyinhealthyandtuberculosispositivesunbearshelarctosmalayanus
AT kriswarren comparativethoracicradiographyinhealthyandtuberculosispositivesunbearshelarctosmalayanus
AT bethanyjackson comparativethoracicradiographyinhealthyandtuberculosispositivesunbearshelarctosmalayanus
AT bethanyjackson comparativethoracicradiographyinhealthyandtuberculosispositivesunbearshelarctosmalayanus