Prevalence and Associated Risk Factors of Retinopathy of Prematurity in Preterm Infants: A Cross-Sectional Study
Objective: To determine the prevalence of Retinopathy of Prematurity (ROP) and its associated risk factors in preterm infants at the National Institute of Child Health (NICH), Karachi, Pakistan. Methods: This cross-sectional study was conducted in the neonatal intensive care unit (NICU) department...
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Dow University of Health Sciences
2024-12-01
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| Series: | Journal of the Dow University of Health Sciences |
| Online Access: | https://jduhs.jduhs.duhs.edu.pk/index.php/jduhs/article/view/2346 |
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| author | Manisha Kumari Mohsina Noor Ibrahim Versha Rani Rai Zubair Khoso Roshia Parveen Ajea Rani |
| author_facet | Manisha Kumari Mohsina Noor Ibrahim Versha Rani Rai Zubair Khoso Roshia Parveen Ajea Rani |
| author_sort | Manisha Kumari |
| collection | DOAJ |
| description |
Objective: To determine the prevalence of Retinopathy of Prematurity (ROP) and its associated risk factors in preterm infants at the National Institute of Child Health (NICH), Karachi, Pakistan.
Methods: This cross-sectional study was conducted in the neonatal intensive care unit (NICU) department of NICH, Karachi, Pakistan from September 2020 to March 2021. The study included preterm infants with a gestational age under 32 weeks, admitted to the NICU at the NICH, Karachi. ROP was diagnosed by indirect ophthalmoscopy following pupil dilation, performed by a trained ophthalmologist. Risk factors were assessed based on preterm infants' age, gestational age, residence, gender, maternal education, sepsis, respiratory distress syndrome (RDS), anemia, oxygen dependency duration, and mechanical ventilation.
Results: Of total 310 preterm infants, the mean age was 5.73 ±1.49 days. There were 184 (59.3%) males and 126 (40.6%) females. ROP was observed in 139 (44.8%) preterm infants. Binary logistic regression indicated significantly increased ROP risk in infants of illiterate mothers (aOR 3.31, 95% CI 1.08 to 10.17, p-value 0.036), those with family income ≤ 45,000 rupees (aOR 3.70, 95% CI 1.40 to 9.76, p-value 0.008), and reduced risk in female infants (aOR 0.12, 95% CI 0.04 to 0.31, p-value <0.001), infants on oxygen ≤ 4 days (aOR 0.04, 95% CI 0.01 to 0.12, p-value <0.001), and NICU stay ≤ 12 days (aOR 0.02, 95% CI 0.01 to 0.08, p-value <0.001).
Conclusion: Nearly half of the preterm neonates were affected by ROP, with contributing factors including maternal illiteracy, low family income, prolonged oxygen dependency, and extended NICU stays.
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| format | Article |
| id | doaj-art-dce3f124760d43e1adc92adcb9c5d5b5 |
| institution | Kabale University |
| issn | 1995-2198 2410-2180 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj-art-dce3f124760d43e1adc92adcb9c5d5b52024-12-17T08:44:14ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802024-12-01183Prevalence and Associated Risk Factors of Retinopathy of Prematurity in Preterm Infants: A Cross-Sectional StudyManisha Kumari0Mohsina Noor Ibrahim1Versha Rani Rai2Zubair Khoso3Roshia Parveen4Ajea Rani5National Institute of Child Health, Jinnah Sindh Medical University, Karachi, Pakistan.National Institute of Child Health, Jinnah Sindh Medical University, Karachi, Pakistan.National Institute of Child Health, Jinnah Sindh Medical University, Karachi, Pakistan.National Institute of Child Health, Jinnah Sindh Medical University, Karachi, Pakistan.National Institute of Child Health, Jinnah Sindh Medical University, Karachi, Pakistan.National Institute of Child Health, Jinnah Sindh Medical University, Karachi, Pakistan. Objective: To determine the prevalence of Retinopathy of Prematurity (ROP) and its associated risk factors in preterm infants at the National Institute of Child Health (NICH), Karachi, Pakistan. Methods: This cross-sectional study was conducted in the neonatal intensive care unit (NICU) department of NICH, Karachi, Pakistan from September 2020 to March 2021. The study included preterm infants with a gestational age under 32 weeks, admitted to the NICU at the NICH, Karachi. ROP was diagnosed by indirect ophthalmoscopy following pupil dilation, performed by a trained ophthalmologist. Risk factors were assessed based on preterm infants' age, gestational age, residence, gender, maternal education, sepsis, respiratory distress syndrome (RDS), anemia, oxygen dependency duration, and mechanical ventilation. Results: Of total 310 preterm infants, the mean age was 5.73 ±1.49 days. There were 184 (59.3%) males and 126 (40.6%) females. ROP was observed in 139 (44.8%) preterm infants. Binary logistic regression indicated significantly increased ROP risk in infants of illiterate mothers (aOR 3.31, 95% CI 1.08 to 10.17, p-value 0.036), those with family income ≤ 45,000 rupees (aOR 3.70, 95% CI 1.40 to 9.76, p-value 0.008), and reduced risk in female infants (aOR 0.12, 95% CI 0.04 to 0.31, p-value <0.001), infants on oxygen ≤ 4 days (aOR 0.04, 95% CI 0.01 to 0.12, p-value <0.001), and NICU stay ≤ 12 days (aOR 0.02, 95% CI 0.01 to 0.08, p-value <0.001). Conclusion: Nearly half of the preterm neonates were affected by ROP, with contributing factors including maternal illiteracy, low family income, prolonged oxygen dependency, and extended NICU stays. https://jduhs.jduhs.duhs.edu.pk/index.php/jduhs/article/view/2346 |
| spellingShingle | Manisha Kumari Mohsina Noor Ibrahim Versha Rani Rai Zubair Khoso Roshia Parveen Ajea Rani Prevalence and Associated Risk Factors of Retinopathy of Prematurity in Preterm Infants: A Cross-Sectional Study Journal of the Dow University of Health Sciences |
| title | Prevalence and Associated Risk Factors of Retinopathy of Prematurity in Preterm Infants: A Cross-Sectional Study |
| title_full | Prevalence and Associated Risk Factors of Retinopathy of Prematurity in Preterm Infants: A Cross-Sectional Study |
| title_fullStr | Prevalence and Associated Risk Factors of Retinopathy of Prematurity in Preterm Infants: A Cross-Sectional Study |
| title_full_unstemmed | Prevalence and Associated Risk Factors of Retinopathy of Prematurity in Preterm Infants: A Cross-Sectional Study |
| title_short | Prevalence and Associated Risk Factors of Retinopathy of Prematurity in Preterm Infants: A Cross-Sectional Study |
| title_sort | prevalence and associated risk factors of retinopathy of prematurity in preterm infants a cross sectional study |
| url | https://jduhs.jduhs.duhs.edu.pk/index.php/jduhs/article/view/2346 |
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