Diagnostic and Prognostic Role of Serum Omentin and NGAL Levels in Egyptian Breast Cancer Patients
Background. Breast cancer (BC) is globally the main cause of cancer-related deaths in women. Tumor biomarkers have significant role in diagnosis and predicting the prognosis and decide the specific therapy to each patient. Aim. In this study, we investigated whether omentin and NGAL levels were alte...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2022/5971981 |
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| author | Al-Shimaa Mahmoud Abas Mohamed H. Sherif Sara A. Elmoneam Farag |
| author_facet | Al-Shimaa Mahmoud Abas Mohamed H. Sherif Sara A. Elmoneam Farag |
| author_sort | Al-Shimaa Mahmoud Abas |
| collection | DOAJ |
| description | Background. Breast cancer (BC) is globally the main cause of cancer-related deaths in women. Tumor biomarkers have significant role in diagnosis and predicting the prognosis and decide the specific therapy to each patient. Aim. In this study, we investigated whether omentin and NGAL levels were altered in patients with breast cancer and the relationship between these markers and their clinicopathological parameters. Subjects and Methods. This study included 120 patients with breast cancer and 30 healthy individuals served as controls. We measured the serum level of omentin and NGAL by ELISA technique. Results. Our results showed that there were statistically significant differences in serum omentin and NGAL levels between two groups. Also, in breast cancer patients, there was significant difference between omentin level, the same results with NGAL level and patient’s age, tumor size, lymph node, and metastasis. No significant relationship was found between omentin level and tumor grade, ER, PR, and HER2. The cutoff value for the prediction of breast cancer was determined at >113.2 ng/ml for omentin and >145.3 ng/ml for NGAL with a sensitivity of 91.7% and 100%, specificity of 100% and 80%, positive predictive value of 100% and 90.9%, negative predictive value of 85.7% and 100%, and accuracy of 94.4% and 93.3%, respectively. In conclusion, serum omentin and NGAL can be used as strong diagnostic markers for breast cancer. |
| format | Article |
| id | doaj-art-dce39005f53646d2a50d61b2015abca0 |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-dce39005f53646d2a50d61b2015abca02025-08-20T03:26:30ZengWileyInternational Journal of Breast Cancer2090-31892022-01-01202210.1155/2022/5971981Diagnostic and Prognostic Role of Serum Omentin and NGAL Levels in Egyptian Breast Cancer PatientsAl-Shimaa Mahmoud Abas0Mohamed H. Sherif1Sara A. Elmoneam Farag2Biochemistry DivisionChemistry DepartmentBiochemistry DivisionBackground. Breast cancer (BC) is globally the main cause of cancer-related deaths in women. Tumor biomarkers have significant role in diagnosis and predicting the prognosis and decide the specific therapy to each patient. Aim. In this study, we investigated whether omentin and NGAL levels were altered in patients with breast cancer and the relationship between these markers and their clinicopathological parameters. Subjects and Methods. This study included 120 patients with breast cancer and 30 healthy individuals served as controls. We measured the serum level of omentin and NGAL by ELISA technique. Results. Our results showed that there were statistically significant differences in serum omentin and NGAL levels between two groups. Also, in breast cancer patients, there was significant difference between omentin level, the same results with NGAL level and patient’s age, tumor size, lymph node, and metastasis. No significant relationship was found between omentin level and tumor grade, ER, PR, and HER2. The cutoff value for the prediction of breast cancer was determined at >113.2 ng/ml for omentin and >145.3 ng/ml for NGAL with a sensitivity of 91.7% and 100%, specificity of 100% and 80%, positive predictive value of 100% and 90.9%, negative predictive value of 85.7% and 100%, and accuracy of 94.4% and 93.3%, respectively. In conclusion, serum omentin and NGAL can be used as strong diagnostic markers for breast cancer.http://dx.doi.org/10.1155/2022/5971981 |
| spellingShingle | Al-Shimaa Mahmoud Abas Mohamed H. Sherif Sara A. Elmoneam Farag Diagnostic and Prognostic Role of Serum Omentin and NGAL Levels in Egyptian Breast Cancer Patients International Journal of Breast Cancer |
| title | Diagnostic and Prognostic Role of Serum Omentin and NGAL Levels in Egyptian Breast Cancer Patients |
| title_full | Diagnostic and Prognostic Role of Serum Omentin and NGAL Levels in Egyptian Breast Cancer Patients |
| title_fullStr | Diagnostic and Prognostic Role of Serum Omentin and NGAL Levels in Egyptian Breast Cancer Patients |
| title_full_unstemmed | Diagnostic and Prognostic Role of Serum Omentin and NGAL Levels in Egyptian Breast Cancer Patients |
| title_short | Diagnostic and Prognostic Role of Serum Omentin and NGAL Levels in Egyptian Breast Cancer Patients |
| title_sort | diagnostic and prognostic role of serum omentin and ngal levels in egyptian breast cancer patients |
| url | http://dx.doi.org/10.1155/2022/5971981 |
| work_keys_str_mv | AT alshimaamahmoudabas diagnosticandprognosticroleofserumomentinandngallevelsinegyptianbreastcancerpatients AT mohamedhsherif diagnosticandprognosticroleofserumomentinandngallevelsinegyptianbreastcancerpatients AT saraaelmoneamfarag diagnosticandprognosticroleofserumomentinandngallevelsinegyptianbreastcancerpatients |