Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy
Abstract Although immunization during pregnancy can protect mothers and their infants from vaccine-preventable morbidity and mortality, vaccination rates are often poor. We systematically reviewed the literature from inception to July 4, 2023, for randomized and non-randomized quasi-experimental stu...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-025-01120-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850181171080593408 |
|---|---|
| author | Annette K. Regan Honorine Uwimana Stacey L. Rowe Elizabeth Jitka Olsanska Brianna Agnew Eliana Castillo Alice Fiddian-Green Michelle L. Giles |
| author_facet | Annette K. Regan Honorine Uwimana Stacey L. Rowe Elizabeth Jitka Olsanska Brianna Agnew Eliana Castillo Alice Fiddian-Green Michelle L. Giles |
| author_sort | Annette K. Regan |
| collection | DOAJ |
| description | Abstract Although immunization during pregnancy can protect mothers and their infants from vaccine-preventable morbidity and mortality, vaccination rates are often poor. We systematically reviewed the literature from inception to July 4, 2023, for randomized and non-randomized quasi-experimental studies estimating the effects of interventions to increase vaccination during pregnancy. Of 9331 studies screened, 36 met inclusion criteria, including 18 demand-side interventions, 11 supply-side interventions, and seven multi-level (demand and supply-side) interventions. Demand-side interventions commonly addressed patient education, showing modest improvement (pooled RR 1.18; 95% CI: 1.04, 1.33; I 2 = 63.1%, low certainty). Supply-side interventions commonly implemented Assessment-Feedback-Incentive-eXchange interventions with little improvement (pooled RR 1.13; 95% CI: 0.96, 1.33; I 2 = 94.0%, low certainty). Multi-level interventions were modestly effective in increasing vaccination (pooled RR 1.62; 95% CI: 1.09, 2.42; I 2 = 97%, very low certainty). Interventions identified in the literature mostly resulted in low to moderate increases in vaccination with likely high heterogeneity and low to very low certainty in the findings. |
| format | Article |
| id | doaj-art-dcdd0be7d24941bc91abe6d04dbfe64d |
| institution | OA Journals |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-dcdd0be7d24941bc91abe6d04dbfe64d2025-08-20T02:17:57ZengNature Portfolionpj Vaccines2059-01052025-04-0110111710.1038/s41541-025-01120-1Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancyAnnette K. Regan0Honorine Uwimana1Stacey L. Rowe2Elizabeth Jitka Olsanska3Brianna Agnew4Eliana Castillo5Alice Fiddian-Green6Michelle L. Giles7Department of Research & Evaluation, Kaiser Permanente Southern CaliforniaSchool of Nursing and Health Professions, University of San FranciscoSchool of Nursing and Health Professions, University of San FranciscoCollege of Arts & Sciences, University of San FranciscoSchool of Nursing and Health Professions, University of San FranciscoDepartments of Medicine and Obstetrics & Gynaecology, University of CalgarySchool of Nursing and Health Professions, University of San FranciscoDepartment of Obstetrics and Gynecology, Monash UniversityAbstract Although immunization during pregnancy can protect mothers and their infants from vaccine-preventable morbidity and mortality, vaccination rates are often poor. We systematically reviewed the literature from inception to July 4, 2023, for randomized and non-randomized quasi-experimental studies estimating the effects of interventions to increase vaccination during pregnancy. Of 9331 studies screened, 36 met inclusion criteria, including 18 demand-side interventions, 11 supply-side interventions, and seven multi-level (demand and supply-side) interventions. Demand-side interventions commonly addressed patient education, showing modest improvement (pooled RR 1.18; 95% CI: 1.04, 1.33; I 2 = 63.1%, low certainty). Supply-side interventions commonly implemented Assessment-Feedback-Incentive-eXchange interventions with little improvement (pooled RR 1.13; 95% CI: 0.96, 1.33; I 2 = 94.0%, low certainty). Multi-level interventions were modestly effective in increasing vaccination (pooled RR 1.62; 95% CI: 1.09, 2.42; I 2 = 97%, very low certainty). Interventions identified in the literature mostly resulted in low to moderate increases in vaccination with likely high heterogeneity and low to very low certainty in the findings.https://doi.org/10.1038/s41541-025-01120-1 |
| spellingShingle | Annette K. Regan Honorine Uwimana Stacey L. Rowe Elizabeth Jitka Olsanska Brianna Agnew Eliana Castillo Alice Fiddian-Green Michelle L. Giles Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy npj Vaccines |
| title | Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy |
| title_full | Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy |
| title_fullStr | Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy |
| title_full_unstemmed | Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy |
| title_short | Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy |
| title_sort | systematic review and meta analysis of interventions to increase the uptake of vaccines recommended during pregnancy |
| url | https://doi.org/10.1038/s41541-025-01120-1 |
| work_keys_str_mv | AT annettekregan systematicreviewandmetaanalysisofinterventionstoincreasetheuptakeofvaccinesrecommendedduringpregnancy AT honorineuwimana systematicreviewandmetaanalysisofinterventionstoincreasetheuptakeofvaccinesrecommendedduringpregnancy AT staceylrowe systematicreviewandmetaanalysisofinterventionstoincreasetheuptakeofvaccinesrecommendedduringpregnancy AT elizabethjitkaolsanska systematicreviewandmetaanalysisofinterventionstoincreasetheuptakeofvaccinesrecommendedduringpregnancy AT briannaagnew systematicreviewandmetaanalysisofinterventionstoincreasetheuptakeofvaccinesrecommendedduringpregnancy AT elianacastillo systematicreviewandmetaanalysisofinterventionstoincreasetheuptakeofvaccinesrecommendedduringpregnancy AT alicefiddiangreen systematicreviewandmetaanalysisofinterventionstoincreasetheuptakeofvaccinesrecommendedduringpregnancy AT michellelgiles systematicreviewandmetaanalysisofinterventionstoincreasetheuptakeofvaccinesrecommendedduringpregnancy |