The diastolic duration as a percentage of the cardiac cycle in healthy adults: A pilot study
Background: A widely accepted concept in cardiovascular physiology states that diastole constitutes 62.5 % of the cardiac cycle during a typical 0.8-s cycle at 75 beats per minute. However, this has not been confirmed by using modern technology in healthy individuals. Objective: This study aimed to...
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Elsevier
2025-03-01
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| Series: | Indian Heart Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483225000409 |
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| author | Neeta Bachani Soorampally Vijay Aniruddha Vyas Jaipal Jadwani Gopikrishna Panicker Yash Lokhandwala |
| author_facet | Neeta Bachani Soorampally Vijay Aniruddha Vyas Jaipal Jadwani Gopikrishna Panicker Yash Lokhandwala |
| author_sort | Neeta Bachani |
| collection | DOAJ |
| description | Background: A widely accepted concept in cardiovascular physiology states that diastole constitutes 62.5 % of the cardiac cycle during a typical 0.8-s cycle at 75 beats per minute. However, this has not been confirmed by using modern technology in healthy individuals. Objective: This study aimed to accurately measure diastolic duration as a fraction of the cardiac cycle using echocardiography in healthy adults with structurally normal hearts. Methods: In this prospective study, 200 healthy adults aged over 18 years, with heart rates between 50 and 100 beats per minute, normal ECGs, and structurally normal hearts, were included. Using a modified apical 5-chamber view and pulse wave Doppler at the aortic and mitral valves, researchers measured the RR interval (total cardiac cycle), diastolic duration (from aortic valve closure to mitral valve closure), and systolic duration. Three measurements were taken for each parameter, and the mean was used for analysis. Results: Participants had a mean age of 47.7 years (range 19–79), with an equal gender distribution. The mean RR interval was 799 ± 97 ms. The left ventricular (LV) diastolic duration was 469 ± 76 ms, and the LV systolic duration was 330 ± 42 ms. The ratio of diastolic duration to the total cardiac cycle was 0.58 ± 0.04, slightly higher in males (0.59 ± 0.04) compared to females (0.57 ± 0.04). Conclusion: This study challenges the longstanding teaching that diastole accounts for two-thirds of the cardiac cycle. Instead, diastole represents 58 % of the cycle, highlighting the need to reconsider its role in cardiovascular physiology and clinical applications. |
| format | Article |
| id | doaj-art-dcdbe437d2734d65b833ab8eb57e1131 |
| institution | DOAJ |
| issn | 0019-4832 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | Indian Heart Journal |
| spelling | doaj-art-dcdbe437d2734d65b833ab8eb57e11312025-08-20T03:13:11ZengElsevierIndian Heart Journal0019-48322025-03-01772737710.1016/j.ihj.2025.02.005The diastolic duration as a percentage of the cardiac cycle in healthy adults: A pilot studyNeeta Bachani0Soorampally Vijay1Aniruddha Vyas2Jaipal Jadwani3Gopikrishna Panicker4Yash Lokhandwala5Department of Cardiology, Holy Family Hospital, Mumbai, IndiaDepartment of Cardiology, AIG Hospital, Hyderabad, India; Corresponding author.Department of Cardiology, Vishesh Jupiter Hospital, Indore, IndiaDepartment of Cardiology, Holy Family Hospital, Mumbai, IndiaIIM, Ahmedabad, IndiaDepartment of Cardiology, Holy Family Hospital, Mumbai, IndiaBackground: A widely accepted concept in cardiovascular physiology states that diastole constitutes 62.5 % of the cardiac cycle during a typical 0.8-s cycle at 75 beats per minute. However, this has not been confirmed by using modern technology in healthy individuals. Objective: This study aimed to accurately measure diastolic duration as a fraction of the cardiac cycle using echocardiography in healthy adults with structurally normal hearts. Methods: In this prospective study, 200 healthy adults aged over 18 years, with heart rates between 50 and 100 beats per minute, normal ECGs, and structurally normal hearts, were included. Using a modified apical 5-chamber view and pulse wave Doppler at the aortic and mitral valves, researchers measured the RR interval (total cardiac cycle), diastolic duration (from aortic valve closure to mitral valve closure), and systolic duration. Three measurements were taken for each parameter, and the mean was used for analysis. Results: Participants had a mean age of 47.7 years (range 19–79), with an equal gender distribution. The mean RR interval was 799 ± 97 ms. The left ventricular (LV) diastolic duration was 469 ± 76 ms, and the LV systolic duration was 330 ± 42 ms. The ratio of diastolic duration to the total cardiac cycle was 0.58 ± 0.04, slightly higher in males (0.59 ± 0.04) compared to females (0.57 ± 0.04). Conclusion: This study challenges the longstanding teaching that diastole accounts for two-thirds of the cardiac cycle. Instead, diastole represents 58 % of the cycle, highlighting the need to reconsider its role in cardiovascular physiology and clinical applications.http://www.sciencedirect.com/science/article/pii/S0019483225000409Cardiac cycleDiastolePulse wave DopplerCardiac physiology |
| spellingShingle | Neeta Bachani Soorampally Vijay Aniruddha Vyas Jaipal Jadwani Gopikrishna Panicker Yash Lokhandwala The diastolic duration as a percentage of the cardiac cycle in healthy adults: A pilot study Indian Heart Journal Cardiac cycle Diastole Pulse wave Doppler Cardiac physiology |
| title | The diastolic duration as a percentage of the cardiac cycle in healthy adults: A pilot study |
| title_full | The diastolic duration as a percentage of the cardiac cycle in healthy adults: A pilot study |
| title_fullStr | The diastolic duration as a percentage of the cardiac cycle in healthy adults: A pilot study |
| title_full_unstemmed | The diastolic duration as a percentage of the cardiac cycle in healthy adults: A pilot study |
| title_short | The diastolic duration as a percentage of the cardiac cycle in healthy adults: A pilot study |
| title_sort | diastolic duration as a percentage of the cardiac cycle in healthy adults a pilot study |
| topic | Cardiac cycle Diastole Pulse wave Doppler Cardiac physiology |
| url | http://www.sciencedirect.com/science/article/pii/S0019483225000409 |
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