Myocardial damage post short-term self-administration cocaine usage in rat
Cocaine abuse remains a significant risk with profound adverse impact on cardiovascular health. While long-term cocaine addiction-induced cardiotoxicity is well-documented, the underlying mechanism and the molecular effects of short-term recreational usage of cocaine on the heart have not been well...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Journal of Molecular and Cellular Cardiology Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772976125001941 |
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| author | Muhammad Zubair Saleem Tian Liu Ningjing Song Jayme McReynolds Chen Gao |
| author_facet | Muhammad Zubair Saleem Tian Liu Ningjing Song Jayme McReynolds Chen Gao |
| author_sort | Muhammad Zubair Saleem |
| collection | DOAJ |
| description | Cocaine abuse remains a significant risk with profound adverse impact on cardiovascular health. While long-term cocaine addiction-induced cardiotoxicity is well-documented, the underlying mechanism and the molecular effects of short-term recreational usage of cocaine on the heart have not been well studied. We established a short-term cocaine exposure rat model through self-administration, mimicking real-world recreational cocaine usage. Our results indicate that even such short-term cocaine usage induces deleterious effect on the heart including pathological remodeling and transcriptome reprogramming associated with major metabolic and contractile processes. This study sheds important insight on the molecular mechanisms of short-term exposure of cocaine-induced cardiovascular damage. |
| format | Article |
| id | doaj-art-dcdbb46403284ae68d03fe98a83204f0 |
| institution | Kabale University |
| issn | 2772-9761 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Molecular and Cellular Cardiology Plus |
| spelling | doaj-art-dcdbb46403284ae68d03fe98a83204f02025-08-20T03:30:09ZengElsevierJournal of Molecular and Cellular Cardiology Plus2772-97612025-09-011310047510.1016/j.jmccpl.2025.100475Myocardial damage post short-term self-administration cocaine usage in ratMuhammad Zubair Saleem0Tian Liu1Ningjing Song2Jayme McReynolds3Chen Gao4Department of Pharmacology, Physiology and Neurobiology, University of Cincinnati, OH, United States of AmericaDepartment of Pharmacology, Physiology and Neurobiology, University of Cincinnati, OH, United States of AmericaDepartment of Pharmacology, Physiology and Neurobiology, University of Cincinnati, OH, United States of AmericaDepartment of Pharmacology, Physiology and Neurobiology, University of Cincinnati, OH, United States of America; Corresponding authors at: Department of Pharmacology, Physiology and Neurobiology, University of Cincinnati, Cincinnati, OH, United States of America.Department of Pharmacology, Physiology and Neurobiology, University of Cincinnati, OH, United States of America; Corresponding authors at: Department of Pharmacology, Physiology and Neurobiology, University of Cincinnati, Cincinnati, OH, United States of America.Cocaine abuse remains a significant risk with profound adverse impact on cardiovascular health. While long-term cocaine addiction-induced cardiotoxicity is well-documented, the underlying mechanism and the molecular effects of short-term recreational usage of cocaine on the heart have not been well studied. We established a short-term cocaine exposure rat model through self-administration, mimicking real-world recreational cocaine usage. Our results indicate that even such short-term cocaine usage induces deleterious effect on the heart including pathological remodeling and transcriptome reprogramming associated with major metabolic and contractile processes. This study sheds important insight on the molecular mechanisms of short-term exposure of cocaine-induced cardiovascular damage.http://www.sciencedirect.com/science/article/pii/S2772976125001941Myocardial damageCocaineMitochondriaTranscriptome |
| spellingShingle | Muhammad Zubair Saleem Tian Liu Ningjing Song Jayme McReynolds Chen Gao Myocardial damage post short-term self-administration cocaine usage in rat Journal of Molecular and Cellular Cardiology Plus Myocardial damage Cocaine Mitochondria Transcriptome |
| title | Myocardial damage post short-term self-administration cocaine usage in rat |
| title_full | Myocardial damage post short-term self-administration cocaine usage in rat |
| title_fullStr | Myocardial damage post short-term self-administration cocaine usage in rat |
| title_full_unstemmed | Myocardial damage post short-term self-administration cocaine usage in rat |
| title_short | Myocardial damage post short-term self-administration cocaine usage in rat |
| title_sort | myocardial damage post short term self administration cocaine usage in rat |
| topic | Myocardial damage Cocaine Mitochondria Transcriptome |
| url | http://www.sciencedirect.com/science/article/pii/S2772976125001941 |
| work_keys_str_mv | AT muhammadzubairsaleem myocardialdamagepostshorttermselfadministrationcocaineusageinrat AT tianliu myocardialdamagepostshorttermselfadministrationcocaineusageinrat AT ningjingsong myocardialdamagepostshorttermselfadministrationcocaineusageinrat AT jaymemcreynolds myocardialdamagepostshorttermselfadministrationcocaineusageinrat AT chengao myocardialdamagepostshorttermselfadministrationcocaineusageinrat |