Aconiti Lateralis Radix Praeparata ameliorates heart failure via PI3K/AKT/Bnip3 pathway

Aconiti Lateralis Radix Praeparata ameliorates heart failure via PI3K/AKT/Bnip3 pathway

BackgroundChronic heart failure (CHF) is one of the leading causes of high mortality worldwide. It is characterized by pathological hypertrophy and poses a major threat to human health. Aconiti Lateralis Radix Praeparata is widely used in ancient China to treat CHF. However, the pathology is obscure...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wenxiu Liu, Xingju Zou, Yang Zheng, Yuan Zhang, Guijuan Cui, Siyu Liu, Chen Sun, Cheng Peng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Pharmacology
Subjects:	Aconiti Lateralis Radix Praeparata transverse aortic constriction chronic heart failure network analysis metabolomics
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1526653/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Pharmacological Evaluation of Polygoni Multiflori Radix Praeparata Extract: Inhibition of PANoptosis in Alleviating Premature Ovarian Insufficiency
by: Can Zhu, et al.
Published: (2025-07-01)

Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota
by: Lingyu Ruan, et al.
Published: (2025-05-01)

Correction: Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota
by: Lingyu Ruan, et al.
Published: (2025-06-01)

Potential induction of the relative mRNA expression levels of CYP450 by Zhicaowu-Hezi (Aconiti kusnezoffii radix preparata and Terminalia chebula Retz.)
by: Junxuan Zhu, et al.
Published: (2025-07-01)

Mechanism of hedysari radix praeparata cum melle and curcumae rhizoma herb pair in colitis-associated colorectal cancer through the MAPK/NF-κB signaling pathway: an investigation in vivo and in vitro
by: Ting Liu, et al.
Published: (2025-05-01)

Primary Hydatid Cyst of the Musculoskeletal System Involving the Femur and Vastus Lateralis
by: Fatih Hakan Tufanoğlu
Published: (2020-08-01)

Proboscis lateralis: A rare case report and brief literature review
by: Hisham Alshwaikh, et al.
Published: (2025-12-01)

Identification of Ginseng Radix et Rhizoma, Panacis Quinquefolii Radix, Notoginseng Radix et Rhizoma, and Platycodonis Radix Based on UHPLC-QTOF-MS and “Matrix Characteristics”
by: Jiating Zhang, et al.
Published: (2024-10-01)

Proboscis lateralis- A 17 years follow-up, a case report
by: Udyan H. Vyas, et al.
Published: (2003-02-01)

Proboscis lateralis- A 17 years follow-up, a case report
by: Vyas U, et al.
Published: (2003-01-01)

Vastus lateralis nerve block for knee hardware removal
by: Jibran Ikram, et al.
Published: (2025-01-01)

Fu’s subcutaneous needling facilitates muscle repair by regulating mitochondrial homeostasis in rat with chronic peripheral nervous pain
by: Po-En Chiu, et al.
Published: (2025-08-01)

The genome sequence of a cranefly, Tipula lateralis Meigen, 1804 [version 1; peer review: 2 approved]
by: Olga Sivell, et al.
Published: (2025-03-01)

Digital identification and adulteration analysis of Codonopsis Radix and Stellariae Radix based on the “digital identity” of chemical compositions
by: Xianrui Wang, et al.
Published: (2024-11-01)

Scutellariae Radix and Atractylodis Macrocephalae Rhizoma pairs ameliorate preeclampsia via PI3K/AKT/eNOS pathway
by: Shujun Sun, et al.
Published: (2025-07-01)

The Effect of Patellar Medial Glide Taping and Vastus Medialis Oblique Taping on Vastus Medialis Oblique and Vastus Lateralis Activity During Wall Squat
by: Jiyun Park, et al.
Published: (2024-12-01)

Direct and delayed effect of the plant Cleome amblyocarpa Barratte & Murb (Capparidaceae) on the two species of (Blattodea) Blattella germanica (Linnaeus, 1767) and Shelfordella lateralis (Walker, 1868)
by: Saliha BENHISSEN, et al.
Published: (2024-12-01)

Crude Radix Aconiti Lateralis Preparata (Fuzi) with Glycyrrhiza Reduces Inflammation and Ventricular Remodeling in Mice through the TLR4/NF-κB Pathway
by: Ping Yan, et al.
Published: (2020-01-01)

Study on the collaborative protective mechanism of Scutellariae Radix and Paeoniae Radix Alba against diabetic cardiomyopathy through the gut-heart axis
by: Cheng Fang, et al.
Published: (2025-04-01)

Determining the Optimum Training Conditions for Selective Strengthening of Vastus Medialis Oblique Muscle over Vastus Lateralis through Using Musculoskeletal Modeling
by: Farzam Farahmand, et al.
Published: (2016-09-01)

Genetic analysis of non-syndromic peg lateralis using whole-exome sequencing
by: Junglim Choi, et al.
Published: (2025-08-01)

Using Network Pharmacology and in vivo Experiments to Uncover the Mechanisms of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules in Treating Diabetes Mellitus-Induced Erectile Dysfunction
by: Wang J, et al.
Published: (2024-12-01)

The prevalence of radix molaris in the mandibular first molars of a Saudi subpopulation based on cone-beam computed tomography
by: Hassan AL-Alawi, et al.
Published: (2020-02-01)

Radix Codonopsis: a review of anticancer pharmacological activities
by: Cai-Yue Liu, et al.
Published: (2025-01-01)

Comparison of the Immune Enhancing Activity and Chemical Constituents Between Imitation Wild and Cultivated Astragali Radix
by: Shuo Zhao, et al.
Published: (2025-02-01)

Development of EST-SSR markers based on transcriptome for genetic analysis in Radix Ardisia
by: Deqiang Ren, et al.
Published: (2025-06-01)

A new mathematical model to improve encryption process based on Split-Radix Fast Fourier Transform algorithm
by: Abdulle Hassan Mohamud
Published: (2025-01-01)

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling
by: Tamás G. Gergely, et al.
Published: (2025-04-01)

Integrated analysis of metabolome, lipidome, and gut microbiome reveals the immunomodulation of Astragali radix in healthy human subjects
by: Wan-Yu Gui, et al.
Published: (2024-12-01)

From Traditional Efficacy to Drug Design: A Review of Astragali Radix
by: Xiaojie Jin, et al.
Published: (2025-03-01)

Optimal extraction of a polysaccharide with antioxidant and hypoglycemic activities from the root of Radix Puerariae lobatae (Willd.) Ohwi
by: Jingjing Fang, et al.
Published: (2024-12-01)

Effects of Paeoniae Radix Rubra on lowering lipid via bioinformatics and gut microbiome
by: Zhi Lin, et al.
Published: (2025-07-01)

The ponticulus of the atlas vertebra: A systematic review and meta-analysis of its prevalence with its surgical relevance
by: Sebastian Ordoñez-Cure, et al.
Published: (2025-10-01)

Prevalence of Radix Entomolaris in Patients at a Multidisciplinary Tertiary Care Hospital of Jharkhand, India
by: Butta Viswanath, et al.
Published: (2025-06-01)

ACUTE EPIGLOTTITIS IN A BOY 3 YEARS
by: O. I. Lekomtseva, et al.
Published: (2016-09-01)

Deciphering the pharmacological mechanism of Radix astragali for allergic rhinitis through network pharmacology and experimental validation
by: Yiwei Hua, et al.
Published: (2024-12-01)

Investigation of Fasciola gigantica in freshwater snail Radix (Lymnaea) spp. In the highly parasite-prevalent area of Nakhon Ratchasima Province, Thailand
by: Pongsakorn Martviset, et al.
Published: (2024-12-01)

Corrigendum: A review of the botany, metabolites, pharmacology, toxicity, industrial applications, and processing of Polygalae Radix: the “key medicine for nourishing life”
by: Hongtuo Kuang, et al.
Published: (2024-11-01)

Successful Endodontic Treatment of Two Cases of Radix Entomolaris in Partially Erupted Mandibular Third Molars with 4 and 3 Root Canals, Respectively
by: Ruchi Shah, et al.
Published: (2022-07-01)

Computer Simulation on Analgesic Functional Chemome Characteristics of <italic>Radix Saposhnikoviae</italic>
by: Chunsong ZHENG, et al.
Published: (2017-08-01)