Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics

Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics

Abstract Backgrounds Atherosclerosis is a major contributor to cardiovascular diseases worldwide. Despite advancements in understanding its pathology, significant gaps remain in the molecular characterization of atherosclerotic plaques. This study addresses this gap by extensively profiling the prot...

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Main Authors: Chaonan Wang, Yuyao Feng, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Keqiang Shu, Deqiang Kong, Jiaxian Wang, Yiran Li, Xiangling Lei, Chen Li, Bao Liu, Wei Sun, Zhichao Lai
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medicine
Subjects:
Carotid artery stenosis
Atherosclerosis
Proteomics
Mendelian randomization
Therapeutic targets
Online Access:https://doi.org/10.1186/s12916-025-04058-2
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