Mechanisms of reduced efficacy of HER2-targeted therapy in HER2-low breast cancer by long-term nicotine exposure in patient-derived xenograft mouse tumor models

Mechanisms of reduced efficacy of HER2-targeted therapy in HER2-low breast cancer by long-term nicotine exposure in patient-derived xenograft mouse tumor models

The effects of long-term nicotine exposure on the treatment of HER2-positive breast cancer have only been studied epidemiologically, leaving the molecular mechanisms unclear. Therefore, it's challenging for clinicians to devise effective treatments based on this correlation. Our investigation e...

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Bibliographic Details
Main Authors: Yu-Hsuan Lin, Yuan-Soon Ho, Bu-Miin Huang, You-Cheng Liao, Tzu-Chun Cheng, Ying-Chi Lin, Shih-Hsin Tu, Yun Yen, Li-Ching Chen
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
α9-nAChR
HER2
Smoking
Breast cancer
Herceptin resistance
Patient-derived xenograft
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325004075
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