Perfusion-based ex vivo culture of frozen ovarian cancer tissues with preserved tumor microenvironment

Perfusion-based ex vivo culture of frozen ovarian cancer tissues with preserved tumor microenvironment

Abstract Ovarian cancer (OC) poses significant treatment challenges due to late-stage diagnosis and a complex tumor microenvironment contributing to therapy resistance. We optimized a U-CUP perfusion-based bioreactor method to culture patient-derived primary and metastatic OC specimens, demonstratin...

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Main Authors: Monica De Luise, Ivana Kurelac, Sara Coluccelli, Antonio De Leo, Ewelina M. Bartoszek, Maria Iorio, Marco Grillini, Camelia Alexandra Coadă, Dario de Biase, Lorena Marchio, Mónica Núñez López, Natalie Rimmer, Anna Myriam Perrone, Pierandrea De Iaco, Anna Maria Porcelli, Viola Heinzelmann, Ivan Martin, Francis Jacob, Manuele Giuseppe Muraro, Giuseppe Gasparre
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00941-6
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