An interesting case of chronic myeloid leukemia with twists and turns
Additional cytogenetic abnormalities (ACA) are known to crop up in Ph+ cells of chronic myeloid leukemia (CML) patients due to cytogenetic evolution. But the frequency of molecular evolution and ACA is much less in Ph− cells of CML patients and is poorly understood. We report an interesting and rare...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S253113792300041X |
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| author | Thulasi Raman Ramalingam J. Subramanian I. Nagarathinam C. Chandran L. Vaidhyanathan J.M. Easow |
| author_facet | Thulasi Raman Ramalingam J. Subramanian I. Nagarathinam C. Chandran L. Vaidhyanathan J.M. Easow |
| author_sort | Thulasi Raman Ramalingam |
| collection | DOAJ |
| description | Additional cytogenetic abnormalities (ACA) are known to crop up in Ph+ cells of chronic myeloid leukemia (CML) patients due to cytogenetic evolution. But the frequency of molecular evolution and ACA is much less in Ph− cells of CML patients and is poorly understood. We report an interesting and rare case of Ph+ CML, who progressed to B lymphoblastic crisis, achieved remission, and later developed Ph− acute myeloid leukemia (AML) with KMT2A gene rearrangement and no detectable BCR- ABL transcripts. |
| format | Article |
| id | doaj-art-dcd2209b83c24f368caa558aeb95ea42 |
| institution | OA Journals |
| issn | 2531-1379 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-dcd2209b83c24f368caa558aeb95ea422025-08-20T02:32:19ZengElsevierHematology, Transfusion and Cell Therapy2531-13792024-12-0146S385S38810.1016/j.htct.2023.02.001An interesting case of chronic myeloid leukemia with twists and turnsThulasi Raman Ramalingam0J. Subramanian1I. Nagarathinam2C. Chandran3L. Vaidhyanathan4J.M. Easow5Apollo Cancer Centre, Chennai, India; Corresponding author at: Department of Hematology, Apollo Hospital, Chennai, 600035, India.Apollo Cancer Centre, Chennai, IndiaApollo Hospital, Chennai, IndiaApollo Hospital, Chennai, IndiaApollo Cancer Centre, Chennai, IndiaApollo Cancer Centre, Chennai, IndiaAdditional cytogenetic abnormalities (ACA) are known to crop up in Ph+ cells of chronic myeloid leukemia (CML) patients due to cytogenetic evolution. But the frequency of molecular evolution and ACA is much less in Ph− cells of CML patients and is poorly understood. We report an interesting and rare case of Ph+ CML, who progressed to B lymphoblastic crisis, achieved remission, and later developed Ph− acute myeloid leukemia (AML) with KMT2A gene rearrangement and no detectable BCR- ABL transcripts.http://www.sciencedirect.com/science/article/pii/S253113792300041XCMLPhiladelphia chromosomeAML |
| spellingShingle | Thulasi Raman Ramalingam J. Subramanian I. Nagarathinam C. Chandran L. Vaidhyanathan J.M. Easow An interesting case of chronic myeloid leukemia with twists and turns Hematology, Transfusion and Cell Therapy CML Philadelphia chromosome AML |
| title | An interesting case of chronic myeloid leukemia with twists and turns |
| title_full | An interesting case of chronic myeloid leukemia with twists and turns |
| title_fullStr | An interesting case of chronic myeloid leukemia with twists and turns |
| title_full_unstemmed | An interesting case of chronic myeloid leukemia with twists and turns |
| title_short | An interesting case of chronic myeloid leukemia with twists and turns |
| title_sort | interesting case of chronic myeloid leukemia with twists and turns |
| topic | CML Philadelphia chromosome AML |
| url | http://www.sciencedirect.com/science/article/pii/S253113792300041X |
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