Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fr...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/502781 |
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| author | Tomasz Topoliński Adam Mazurkiewicz Stanislaw Jung Artur Cichański Krzysztof Nowicki |
| author_facet | Tomasz Topoliński Adam Mazurkiewicz Stanislaw Jung Artur Cichański Krzysztof Nowicki |
| author_sort | Tomasz Topoliński |
| collection | DOAJ |
| description | Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fractal dimension, and bone mineral density are correlated with bone strength. Methods. Forty-two human bone samples harvested during total hip replacement surgery were cut to cylindrical samples. The geometrical mesh of layers of bone mass obtained from microCT investigation and the volumes of each layer and fractal dimension were calculated. The finite element method was applied to calculate the compression force F causing ε=0.8% strain. Results. There were stronger correlations for microarchitecture parameters with strength than those for bone mineral density. The values of determination coefficient R2 for mean volume and force were 0.88 and 0.90 for mean fractal dimension and force, while for BMD and force the value was 0.53. The samples with bigger mean bone volume of layers and bigger mean fractal dimension of layers (more complex structure) presented higher strength. Conclusion. The volumetric and fractal dimension parameters better describe bone structure and strength than BMD. |
| format | Article |
| id | doaj-art-dccc473d3ef147729f5ff284f975e6d7 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-dccc473d3ef147729f5ff284f975e6d72025-02-03T06:07:35ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/502781502781Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMDTomasz Topoliński0Adam Mazurkiewicz1Stanislaw Jung2Artur Cichański3Krzysztof Nowicki4Faculty of Mechanical Engineering, University of Technology and Life Sciences, Kaliskiego 7 Street, 85-789 Bydgoszcz, PolandFaculty of Mechanical Engineering, University of Technology and Life Sciences, Kaliskiego 7 Street, 85-789 Bydgoszcz, PolandSouth Tyneside Hospital, South Shields, Tyne and Wear NE 34 OPL, UKFaculty of Mechanical Engineering, University of Technology and Life Sciences, Kaliskiego 7 Street, 85-789 Bydgoszcz, PolandFaculty of Mechanical Engineering, University of Technology and Life Sciences, Kaliskiego 7 Street, 85-789 Bydgoszcz, PolandIntroduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fractal dimension, and bone mineral density are correlated with bone strength. Methods. Forty-two human bone samples harvested during total hip replacement surgery were cut to cylindrical samples. The geometrical mesh of layers of bone mass obtained from microCT investigation and the volumes of each layer and fractal dimension were calculated. The finite element method was applied to calculate the compression force F causing ε=0.8% strain. Results. There were stronger correlations for microarchitecture parameters with strength than those for bone mineral density. The values of determination coefficient R2 for mean volume and force were 0.88 and 0.90 for mean fractal dimension and force, while for BMD and force the value was 0.53. The samples with bigger mean bone volume of layers and bigger mean fractal dimension of layers (more complex structure) presented higher strength. Conclusion. The volumetric and fractal dimension parameters better describe bone structure and strength than BMD.http://dx.doi.org/10.1100/2012/502781 |
| spellingShingle | Tomasz Topoliński Adam Mazurkiewicz Stanislaw Jung Artur Cichański Krzysztof Nowicki Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD The Scientific World Journal |
| title | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
| title_full | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
| title_fullStr | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
| title_full_unstemmed | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
| title_short | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
| title_sort | microarchitecture parameters describe bone structure and its strength better than bmd |
| url | http://dx.doi.org/10.1100/2012/502781 |
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