Diabetes mellitus aggravates myocardial inflammation and oxidative stress in aortic stenosis: a mechanistic link to HFpEF features

Diabetes mellitus aggravates myocardial inflammation and oxidative stress in aortic stenosis: a mechanistic link to HFpEF features

Abstract Background Patients diagnosed with both aortic stenosis (AS) and diabetes mellitus (DM) encounter a distinctive set of challenges due to the interplay between these two conditions. This study aimed to investigate the effects of DM on the left ventricle in AS patients, specifically focusing...

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Main Authors: Melissa Herwig, Marcel Sieme, Andrea Kovács, Muchtiar Khan, Andreas Mügge, Wolfgang E. Schmidt, Ferhat Elci, Shan Sasidharan, Peter Haldenwang, Jan Wintrich, Benjamin Sasko, Ibrahim Akin, Máthé Domokos, Francesco Paneni, Ibrahim El-Battrawy, Zoltán V. Varga, Francisca Saraiva, Adelino F. Leite-Moreira, Péter Ferdinandy, Loek van Heerebeek, Inês Falcão-Pires, Nazha Hamdani
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cardiovascular Diabetology
Subjects:
Aortic stenosis
Diabetes mellitus
Cardiomyocyte Fpassive
Heart failure with preserved ejection fraction
Inflammation
Oxidative stress
Online Access:https://doi.org/10.1186/s12933-025-02748-y
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