Effectiveness of Antimicrobial Stewardship Program in Long-Term Care: A Five-Year Prospective Single-Center Study
Objective. To report the effectiveness of the antimicrobial stewardship program (ASP) in a long-term care (LTC) facility, by analyzing the change in antimicrobial consumption and cost and multidrug resistance (MDR) rates over a 5-year period. Method. A prospective interventional study was conducted...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2022/8140429 |
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| author | Maha Mahmoud Alawi Wail A Tashkandi Mohamed A Basheikh Faten M Warshan Hazem Ahmed Ghobara Rosemarie B. Ramos Mary Leilani Guiriba Omar Ayob Safiah Saad Janah Anees Ahmad Sindi Suheib Ali Abdulhamid Ahmed Salah Dammnan Esam Ibraheem Azhar Ali A. Rabaan Salma Alnahdi Maged Mohammed Bamahakesh |
| author_facet | Maha Mahmoud Alawi Wail A Tashkandi Mohamed A Basheikh Faten M Warshan Hazem Ahmed Ghobara Rosemarie B. Ramos Mary Leilani Guiriba Omar Ayob Safiah Saad Janah Anees Ahmad Sindi Suheib Ali Abdulhamid Ahmed Salah Dammnan Esam Ibraheem Azhar Ali A. Rabaan Salma Alnahdi Maged Mohammed Bamahakesh |
| author_sort | Maha Mahmoud Alawi |
| collection | DOAJ |
| description | Objective. To report the effectiveness of the antimicrobial stewardship program (ASP) in a long-term care (LTC) facility, by analyzing the change in antimicrobial consumption and cost and multidrug resistance (MDR) rates over a 5-year period. Method. A prospective interventional study was conducted at a 106-bed facility (nursing home: 100 beds and an intensive care unit (ICU): 6 beds). The ASP was designed and led by a multidisciplinary team including an infectious disease consultant, two clinical pharmacists, a clinical microbiologist, and an infection control preventionist. Five key performance indicators were monitored: (1) intravenous (IV)-to-oral switch rate, (2) consumption of restricted IV antimicrobials (raw consumption and defined daily doses (DDD) index), (3) cost of restricted IV antimicrobials, (4) antimicrobial sensitivity profiles, and (5) MDR rate among hospital-acquired infections (MDR-HAI). Result. A ∼5.5-fold enhancement of the IV-to-oral switch and a 40% reduction in the overall consumption of restricted IV antimicrobials were observed. Regarding the cost, the cumulative cost saving was estimated as 5.64 million SAR (US$1.50 million). Microbiologically, no significant change in antimicrobial sensitivity profiles was observed; however, a large-size reduction in the MDR-HAI rate was observed, notably in ICU where it declined from 3.22 per 1,000 patient days, in 2015, to 1.14 per 1,000 patient days in 2020. Interestingly, the yearly overall MDR rate was strongly correlated with the level of antimicrobial consumption. Conclusion. The implementation of a multidisciplinary ASP in LTC facilities should be further encouraged, with emphasis on physicians’ education and active involvement to enhance the success of the strategy. |
| format | Article |
| id | doaj-art-dcc8acdca16b4b49a54ee4a5cfdbf283 |
| institution | DOAJ |
| issn | 1687-7098 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-dcc8acdca16b4b49a54ee4a5cfdbf2832025-08-20T03:23:56ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-70982022-01-01202210.1155/2022/8140429Effectiveness of Antimicrobial Stewardship Program in Long-Term Care: A Five-Year Prospective Single-Center StudyMaha Mahmoud Alawi0Wail A Tashkandi1Mohamed A Basheikh2Faten M Warshan3Hazem Ahmed Ghobara4Rosemarie B. Ramos5Mary Leilani Guiriba6Omar Ayob7Safiah Saad Janah8Anees Ahmad Sindi9Suheib Ali Abdulhamid Ahmed10Salah Dammnan11Esam Ibraheem Azhar12Ali A. Rabaan13Salma Alnahdi14Maged Mohammed Bamahakesh15Department of Medical Microbiology and ParasitologyDepartment of SurgeryFaculty of MedicineInternational Extended Care CenterInternational Extended Care CenterInfection Control DepartmentInfection Control DepartmentKing Abdulaziz UniversityInternational Extended Care CenterDepartment of Anesthesia and Critical CareInternational Extended Care CenterInternational Extended Care CenterSpecial Infectious Agents Unit—BSL3Molecular Diagnostic LaboratoryInternational Extended Care CenterInternational Extended Care CenterObjective. To report the effectiveness of the antimicrobial stewardship program (ASP) in a long-term care (LTC) facility, by analyzing the change in antimicrobial consumption and cost and multidrug resistance (MDR) rates over a 5-year period. Method. A prospective interventional study was conducted at a 106-bed facility (nursing home: 100 beds and an intensive care unit (ICU): 6 beds). The ASP was designed and led by a multidisciplinary team including an infectious disease consultant, two clinical pharmacists, a clinical microbiologist, and an infection control preventionist. Five key performance indicators were monitored: (1) intravenous (IV)-to-oral switch rate, (2) consumption of restricted IV antimicrobials (raw consumption and defined daily doses (DDD) index), (3) cost of restricted IV antimicrobials, (4) antimicrobial sensitivity profiles, and (5) MDR rate among hospital-acquired infections (MDR-HAI). Result. A ∼5.5-fold enhancement of the IV-to-oral switch and a 40% reduction in the overall consumption of restricted IV antimicrobials were observed. Regarding the cost, the cumulative cost saving was estimated as 5.64 million SAR (US$1.50 million). Microbiologically, no significant change in antimicrobial sensitivity profiles was observed; however, a large-size reduction in the MDR-HAI rate was observed, notably in ICU where it declined from 3.22 per 1,000 patient days, in 2015, to 1.14 per 1,000 patient days in 2020. Interestingly, the yearly overall MDR rate was strongly correlated with the level of antimicrobial consumption. Conclusion. The implementation of a multidisciplinary ASP in LTC facilities should be further encouraged, with emphasis on physicians’ education and active involvement to enhance the success of the strategy.http://dx.doi.org/10.1155/2022/8140429 |
| spellingShingle | Maha Mahmoud Alawi Wail A Tashkandi Mohamed A Basheikh Faten M Warshan Hazem Ahmed Ghobara Rosemarie B. Ramos Mary Leilani Guiriba Omar Ayob Safiah Saad Janah Anees Ahmad Sindi Suheib Ali Abdulhamid Ahmed Salah Dammnan Esam Ibraheem Azhar Ali A. Rabaan Salma Alnahdi Maged Mohammed Bamahakesh Effectiveness of Antimicrobial Stewardship Program in Long-Term Care: A Five-Year Prospective Single-Center Study Interdisciplinary Perspectives on Infectious Diseases |
| title | Effectiveness of Antimicrobial Stewardship Program in Long-Term Care: A Five-Year Prospective Single-Center Study |
| title_full | Effectiveness of Antimicrobial Stewardship Program in Long-Term Care: A Five-Year Prospective Single-Center Study |
| title_fullStr | Effectiveness of Antimicrobial Stewardship Program in Long-Term Care: A Five-Year Prospective Single-Center Study |
| title_full_unstemmed | Effectiveness of Antimicrobial Stewardship Program in Long-Term Care: A Five-Year Prospective Single-Center Study |
| title_short | Effectiveness of Antimicrobial Stewardship Program in Long-Term Care: A Five-Year Prospective Single-Center Study |
| title_sort | effectiveness of antimicrobial stewardship program in long term care a five year prospective single center study |
| url | http://dx.doi.org/10.1155/2022/8140429 |
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