DNA methylation in chronic kidney disease
Abstract Chronic kidney disease (CKD) is a condition that affects people on a global scale. After various stages of progression, CKD is finally characterized by renal fibrosis. As the most pervasive and well-studied epigenetic modification, DNA methylation has recently been associated with the devel...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-024-03916-0 |
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| author | Ye Cheng Pei Liu Guiling Xie Wenjun Li Huan Jing Yanna Chen Hongtao Chen Youlin Fan Jun Zhou |
| author_facet | Ye Cheng Pei Liu Guiling Xie Wenjun Li Huan Jing Yanna Chen Hongtao Chen Youlin Fan Jun Zhou |
| author_sort | Ye Cheng |
| collection | DOAJ |
| description | Abstract Chronic kidney disease (CKD) is a condition that affects people on a global scale. After various stages of progression, CKD is finally characterized by renal fibrosis. As the most pervasive and well-studied epigenetic modification, DNA methylation has recently been associated with the development of renal fibrosis. Gaining a better understanding of the link between DNA methylation and CKD would provide new targets or enable the development of epigenetic therapies for CKD. This review discusses the mechanisms by which DNA methylation regulates gene expression during the pathological process of CKD, including the role of DNA methyltransferases (DNMTs). This review summarizes DNA methylation in CKD, particularly its crucial role in CKD-related conditions, such as diabetic kidney disease (DKD) and chronic allograft injury. Conventional demethylating agents have been discussed as well as the need for less toxic demethylating agents for clinical applications. Finally, some of the problems and obstacles specified in previous DNA methylation studies have been considered. This information aims to promote further investigations into the role of DNA methylation in CKD by providing novel insights into the mechanism by which methylation affects the progression and regression of CKD, which would result in the development of alternate treatments. |
| format | Article |
| id | doaj-art-dcc5354c1f7d43ce9c24ea77cf0e73e6 |
| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-dcc5354c1f7d43ce9c24ea77cf0e73e62025-08-20T03:45:51ZengBMCBMC Nephrology1471-23692025-08-0126111110.1186/s12882-024-03916-0DNA methylation in chronic kidney diseaseYe Cheng0Pei Liu1Guiling Xie2Wenjun Li3Huan Jing4Yanna Chen5Hongtao Chen6Youlin Fan7Jun Zhou8Department of Anesthesiology, The Third Affiliated Hospital of Southern Medical UniversityDepartment of Anesthesiology, The Third Affiliated Hospital of Southern Medical UniversityDepartment of Anesthesiology, The Third Affiliated Hospital of Southern Medical UniversityDepartment of Anesthesiology, The Third Affiliated Hospital of Southern Medical UniversityDepartment of Anesthesiology, The First People’s Hospital of FoshanDepartment of Anesthesiology, The Third Affiliated Hospital of Southern Medical UniversityDepartment of Anesthesiology, The Eighth People’s Hospital of GuangzhouDepartment of Anesthesiology, Guangzhou Panyu Central Hospital of Panyu DistrictDepartment of Anesthesiology, The Third Affiliated Hospital of Southern Medical UniversityAbstract Chronic kidney disease (CKD) is a condition that affects people on a global scale. After various stages of progression, CKD is finally characterized by renal fibrosis. As the most pervasive and well-studied epigenetic modification, DNA methylation has recently been associated with the development of renal fibrosis. Gaining a better understanding of the link between DNA methylation and CKD would provide new targets or enable the development of epigenetic therapies for CKD. This review discusses the mechanisms by which DNA methylation regulates gene expression during the pathological process of CKD, including the role of DNA methyltransferases (DNMTs). This review summarizes DNA methylation in CKD, particularly its crucial role in CKD-related conditions, such as diabetic kidney disease (DKD) and chronic allograft injury. Conventional demethylating agents have been discussed as well as the need for less toxic demethylating agents for clinical applications. Finally, some of the problems and obstacles specified in previous DNA methylation studies have been considered. This information aims to promote further investigations into the role of DNA methylation in CKD by providing novel insights into the mechanism by which methylation affects the progression and regression of CKD, which would result in the development of alternate treatments.https://doi.org/10.1186/s12882-024-03916-0Chronic kidney diseaseRenal fibrosisDNA methyltransferasesDiabetic kidney diseaseChronic allograft injuryDemethylating agents |
| spellingShingle | Ye Cheng Pei Liu Guiling Xie Wenjun Li Huan Jing Yanna Chen Hongtao Chen Youlin Fan Jun Zhou DNA methylation in chronic kidney disease BMC Nephrology Chronic kidney disease Renal fibrosis DNA methyltransferases Diabetic kidney disease Chronic allograft injury Demethylating agents |
| title | DNA methylation in chronic kidney disease |
| title_full | DNA methylation in chronic kidney disease |
| title_fullStr | DNA methylation in chronic kidney disease |
| title_full_unstemmed | DNA methylation in chronic kidney disease |
| title_short | DNA methylation in chronic kidney disease |
| title_sort | dna methylation in chronic kidney disease |
| topic | Chronic kidney disease Renal fibrosis DNA methyltransferases Diabetic kidney disease Chronic allograft injury Demethylating agents |
| url | https://doi.org/10.1186/s12882-024-03916-0 |
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