Trend of Use of Quinolone Antibiotics in Community-Acquired Pneumonia
Introduction: Quinolone group antibiotics are frequently used in the treatment of community-acquired pneumonia (CAP). There have also been rising safety concerns related to quinolone usage. In this study, we investigated physicians’ tendencies to prescribe quinolones when managing outpatient pneumon...
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| Format: | Article |
| Language: | Turkish |
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Galenos Yayinevi
2025-01-01
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| Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
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| Online Access: | https://mjima.org/articles/trend-of-use-of-quinolone-antibiotics-in-community-acquired-pneumonia/doi/mjima.galenos.2024.24291.1 |
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| _version_ | 1841560812724944896 |
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| author | Kadir Burak AKGÜN Emel CEYLAN Mehmet KARADAĞ Merve AYIK TÜRK |
| author_facet | Kadir Burak AKGÜN Emel CEYLAN Mehmet KARADAĞ Merve AYIK TÜRK |
| author_sort | Kadir Burak AKGÜN |
| collection | DOAJ |
| description | Introduction: Quinolone group antibiotics are frequently used in the treatment of community-acquired pneumonia (CAP). There have also been rising safety concerns related to quinolone usage. In this study, we investigated physicians’ tendencies to prescribe quinolones when managing outpatient pneumonia treatment and the factors influencing this decision.
Materials and Methods: Physicians were asked to participate in a survey consisting of 20 questions. They were queried about the antibiotic groups they most frequently prescribe for outpatient treatment in cases of CAP, the specific type of quinolone they most commonly used, their opinions on the effects and side effects of quinolones through Likert-type survey, and the clinical scenarios that lead them to prescribe quinolones. In addition, a comparison was made between pulmonologists and other specialists on these factors.
Results: A total of 16.29% of physicians primarily prescribed quinolones. The most preferred quinolone was moxifloxacin (50%). In cases of treatment failure, physicians were more likely to opt for hospitalization and a broad-spectrum antibiotic treatment approach (78.09%). Pulmonologists were more likely to prescribe quinolones in cases of unresponsiveness to previous beta-lactam therapy and complicated pneumonia than nonpulmonologists (p=0.013, p=0.044, respectively). Pulmonologists placed more importance on the tendinitis side effect compared to nonpulmonologists (p=0.019). Among the clinical factors, the previous use of beta-lactam antibiotics and the presence of chronic disease in the patient’s medical history were significantly associated with physicians who preferred quinolones as their first choice compared with those who did not (p=0.008 and p=0.006, respectively).
Conclusion: The fact that quinolones can be used alone and contribute to the speed of recovery is appealing to clinicians. However, the relevant guidelines conflict with each other regarding their first-line of use in CAP. In addition, knowledge about the side effects of quinolones is increasing. The prescription rates of quinolones should therefore be closely monitored and in cases of an increase in the prescription rates, legal regulations should be more strictly adhered to if guideline recommendations are inadequate. |
| format | Article |
| id | doaj-art-dcc21dd2a0c04f7caf9f8400166a8333 |
| institution | Kabale University |
| issn | 2147-673X |
| language | Turkish |
| publishDate | 2025-01-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| spelling | doaj-art-dcc21dd2a0c04f7caf9f8400166a83332025-01-03T13:59:23ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2025-01-011411110.4274/mjima.galenos.2024.24291.1Trend of Use of Quinolone Antibiotics in Community-Acquired PneumoniaKadir Burak AKGÜN0https://orcid.org/0000-0002-3017-1025Emel CEYLAN1https://orcid.org/0000-0002-4723-2285Mehmet KARADAĞ2https://orcid.org/0000-0001-9539-4193Merve AYIK TÜRK3https://orcid.org/0000-0003-3106-7403Hatay Mustafa Kemal University Faculty of Medicine, Department of Pulmonology, Hatay, TürkiyeAydın Adnan Menderes University Faculty of Medicine, Department of Pulmonology, Aydın, TürkiyeHatay Mustafa Kemal University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Hatay, TürkiyeUniversity of Health Siences Türkiye, İzmir Bozyaka Training and Research Hospita, Clinic of Pulmonology, İzmir, TürkiyeIntroduction: Quinolone group antibiotics are frequently used in the treatment of community-acquired pneumonia (CAP). There have also been rising safety concerns related to quinolone usage. In this study, we investigated physicians’ tendencies to prescribe quinolones when managing outpatient pneumonia treatment and the factors influencing this decision. Materials and Methods: Physicians were asked to participate in a survey consisting of 20 questions. They were queried about the antibiotic groups they most frequently prescribe for outpatient treatment in cases of CAP, the specific type of quinolone they most commonly used, their opinions on the effects and side effects of quinolones through Likert-type survey, and the clinical scenarios that lead them to prescribe quinolones. In addition, a comparison was made between pulmonologists and other specialists on these factors. Results: A total of 16.29% of physicians primarily prescribed quinolones. The most preferred quinolone was moxifloxacin (50%). In cases of treatment failure, physicians were more likely to opt for hospitalization and a broad-spectrum antibiotic treatment approach (78.09%). Pulmonologists were more likely to prescribe quinolones in cases of unresponsiveness to previous beta-lactam therapy and complicated pneumonia than nonpulmonologists (p=0.013, p=0.044, respectively). Pulmonologists placed more importance on the tendinitis side effect compared to nonpulmonologists (p=0.019). Among the clinical factors, the previous use of beta-lactam antibiotics and the presence of chronic disease in the patient’s medical history were significantly associated with physicians who preferred quinolones as their first choice compared with those who did not (p=0.008 and p=0.006, respectively). Conclusion: The fact that quinolones can be used alone and contribute to the speed of recovery is appealing to clinicians. However, the relevant guidelines conflict with each other regarding their first-line of use in CAP. In addition, knowledge about the side effects of quinolones is increasing. The prescription rates of quinolones should therefore be closely monitored and in cases of an increase in the prescription rates, legal regulations should be more strictly adhered to if guideline recommendations are inadequate.https://mjima.org/articles/trend-of-use-of-quinolone-antibiotics-in-community-acquired-pneumonia/doi/mjima.galenos.2024.24291.1floroquinolonespneumoniasurveysquestionnaires |
| spellingShingle | Kadir Burak AKGÜN Emel CEYLAN Mehmet KARADAĞ Merve AYIK TÜRK Trend of Use of Quinolone Antibiotics in Community-Acquired Pneumonia Mediterranean Journal of Infection, Microbes and Antimicrobials floroquinolones pneumonia surveys questionnaires |
| title | Trend of Use of Quinolone Antibiotics in Community-Acquired Pneumonia |
| title_full | Trend of Use of Quinolone Antibiotics in Community-Acquired Pneumonia |
| title_fullStr | Trend of Use of Quinolone Antibiotics in Community-Acquired Pneumonia |
| title_full_unstemmed | Trend of Use of Quinolone Antibiotics in Community-Acquired Pneumonia |
| title_short | Trend of Use of Quinolone Antibiotics in Community-Acquired Pneumonia |
| title_sort | trend of use of quinolone antibiotics in community acquired pneumonia |
| topic | floroquinolones pneumonia surveys questionnaires |
| url | https://mjima.org/articles/trend-of-use-of-quinolone-antibiotics-in-community-acquired-pneumonia/doi/mjima.galenos.2024.24291.1 |
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