Humoral and cellular immune response to a single dose of a novel bivalent recombinant adenovirus-vector vaccine against West Nile virus and chikungunya virus in mice

Humoral and cellular immune response to a single dose of a novel bivalent recombinant adenovirus-vector vaccine against West Nile virus and chikungunya virus in mice

Abstract Background West Nile virus (WNV) and chikungunya virus (CHIKV) are zoonotic pathogens transmitted by mosquitoes, which cause significant morbidity and mortality globally. Currently, no human vaccine is available against both WNV and CHIKV. Methods In this study, we developed a novel bivalen...

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Main Authors: Shu Chang, Guo Xiaojuan, Han Xiaotian, Li Mengzhe, Zhai Chengcheng, Bing Jialuo, Jin Liye, Jiang Yujie, Li Jia, Wang Tangqi, Qi Zhenyong, Zhai Desheng, Deng Yao, Lu Zhuozhuang, Tan Wenjie
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Virology Journal
Subjects:
West Nile virus
Chikungunya virus
Bivalent adenovirus-vector vaccine
Humoral immune response
Cellular immune response
C57BL/6 mice
Online Access:https://doi.org/10.1186/s12985-025-02878-5
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