Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage
Background: Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of classical music on CBFV and other physiological parameters in p...
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Elsevier
2025-12-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242125000909 |
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| author | Nicolas Eden Marius Marc-Daniel Mader Jan Bremer Jennifer Sauvigny Jörn Grensemann Marlene Fischer Nils Schweingruber Jens Gempt Patrick Czorlich |
| author_facet | Nicolas Eden Marius Marc-Daniel Mader Jan Bremer Jennifer Sauvigny Jörn Grensemann Marlene Fischer Nils Schweingruber Jens Gempt Patrick Czorlich |
| author_sort | Nicolas Eden |
| collection | DOAJ |
| description | Background: Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of classical music on CBFV and other physiological parameters in patients suffering from aneurysmal subarachnoid hemorrhage (SAH). Methods: Twenty patients with SAH were subjected to up to three interventions, in which the patients listened to W. A. Mozart's Symphony No. 40 in G minor. In parallel, CBFV in the right middle cerebral artery (MCA) was continuously measured using transcranial Doppler (TCD). TCD values were averaged per minute, normalized, and analyzed with a mixed-effects linear regression model. In addition, other physiological and laboratory parameters were evaluated. Results: A total of 55 interventions were successfully carried out. The mixed-effects linear regression model revealed significant associations with both time (p < 0.001) and session (p = 0.002), specifically, with each minute of classical music played, there was a 0.3 % reduction in CBFV (95 % confidence interval (CI): 0.2–0.4 %). Heart rate (HR) and respiratory rate (RR) decreased by 0.1 % (95 % CI: −0.2–0.0 %; p = 0.043) 0.3 % (95 % CI: −0.6 % to −0.1 %; p = 0.001), respectively, per minute of exposure. Each additional session resulted in a reduction of HR by 4.3 % and RR by 22.3 % from the baseline at the start of the intervention to minute 25 (both p < 0.001). Conclusions: Our pilot study shows only a very small effect of classical music such as Mozart's Symphony No. 40 in G minor in patients with SAH. |
| format | Article |
| id | doaj-art-dcbec065855c4cbdba42bb955d12fb23 |
| institution | OA Journals |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-dcbec065855c4cbdba42bb955d12fb232025-08-20T02:35:19ZengElsevierIBRO Neuroscience Reports2667-24212025-12-011919820410.1016/j.ibneur.2025.06.008Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhageNicolas Eden0Marius Marc-Daniel Mader1Jan Bremer2Jennifer Sauvigny3Jörn Grensemann4Marlene Fischer5Nils Schweingruber6Jens Gempt7Patrick Czorlich8Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, GermanyDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, United StatesDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, GermanyDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, GermanyDepartment of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, GermanyDepartment of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, GermanyDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, GermanyDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, GermanyDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany; Correspondence to: University Medical Center Hamburg-Eppendorf, Department of Neurosurgery, Martinistr. 52, Hamburg 20246, Germany.Background: Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of classical music on CBFV and other physiological parameters in patients suffering from aneurysmal subarachnoid hemorrhage (SAH). Methods: Twenty patients with SAH were subjected to up to three interventions, in which the patients listened to W. A. Mozart's Symphony No. 40 in G minor. In parallel, CBFV in the right middle cerebral artery (MCA) was continuously measured using transcranial Doppler (TCD). TCD values were averaged per minute, normalized, and analyzed with a mixed-effects linear regression model. In addition, other physiological and laboratory parameters were evaluated. Results: A total of 55 interventions were successfully carried out. The mixed-effects linear regression model revealed significant associations with both time (p < 0.001) and session (p = 0.002), specifically, with each minute of classical music played, there was a 0.3 % reduction in CBFV (95 % confidence interval (CI): 0.2–0.4 %). Heart rate (HR) and respiratory rate (RR) decreased by 0.1 % (95 % CI: −0.2–0.0 %; p = 0.043) 0.3 % (95 % CI: −0.6 % to −0.1 %; p = 0.001), respectively, per minute of exposure. Each additional session resulted in a reduction of HR by 4.3 % and RR by 22.3 % from the baseline at the start of the intervention to minute 25 (both p < 0.001). Conclusions: Our pilot study shows only a very small effect of classical music such as Mozart's Symphony No. 40 in G minor in patients with SAH.http://www.sciencedirect.com/science/article/pii/S2667242125000909subarachnoid hemorrhagephysiological effectsvasospasmclassical musicMozart |
| spellingShingle | Nicolas Eden Marius Marc-Daniel Mader Jan Bremer Jennifer Sauvigny Jörn Grensemann Marlene Fischer Nils Schweingruber Jens Gempt Patrick Czorlich Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage IBRO Neuroscience Reports subarachnoid hemorrhage physiological effects vasospasm classical music Mozart |
| title | Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage |
| title_full | Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage |
| title_fullStr | Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage |
| title_full_unstemmed | Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage |
| title_short | Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage |
| title_sort | mozart for the brain a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage |
| topic | subarachnoid hemorrhage physiological effects vasospasm classical music Mozart |
| url | http://www.sciencedirect.com/science/article/pii/S2667242125000909 |
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