Effects of alpha-ketoisocaproate in oxidative stress-induced C2C12 myotubes via inhibition of p38 MAPK and ERK1/2

Effects of alpha-ketoisocaproate in oxidative stress-induced C2C12 myotubes via inhibition of p38 MAPK and ERK1/2

Sarcopenia is an age-related muscle atrophy characterized by decreased muscle mass and function. However, potential treatments to alleviate sarcopenia remain limited. In this study, we investigated the effects of α-ketoisocaproate (KIC) on C2C12 differentiation and reactive oxygen species (ROS)-indu...

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Bibliographic Details
Main Authors: Pooreum Lim, Sang Woo Woo, Jihye Han, Young Lim Lee, Jae Ho Shim, Hyeon Soo Kim
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
α-ketoisocaproate
C2C12
ERK1/2
Muscle atrophy
Sarcopenia
p38 MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825000421
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