Akinetic mutism due to diphenylhydantoin toxicity
Akinetic mutism (AM) is a rare, specific, unconscious state. An AM patient seems to be awake, lacks mental activity, is unable to speak, and does not respond to any environmental stimulus. Cyclical sleep and awake states are maintained, and incontinence is present. Various factors such as tum...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
1997-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3417 |
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| _version_ | 1849772698130972672 |
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| author | S Tütüncüoğlu M Kantar H Tekgül C Candan |
| author_facet | S Tütüncüoğlu M Kantar H Tekgül C Candan |
| author_sort | S Tütüncüoğlu |
| collection | DOAJ |
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Akinetic mutism (AM) is a rare, specific, unconscious state. An AM patient seems to be awake, lacks mental activity, is unable to speak, and does not respond to any environmental stimulus. Cyclical sleep and awake states are maintained, and incontinence is present. Various factors such as tumor, vascular events, drug use and radiotherapy are responsible for the development of AM. A 12-year-old epileptic patient displayed AM and diphenylhydantoin toxicity (DPH). She seemed awake, was unable to speak or to understand, and had no movements with either spontaneous or noxious stimuli. Her serum DPH level was greater than 40 micrograms/ml. Magnetic resonance imaging (MRI) showed mild cerebellar atrophy. All known causes of AM were excluded. The AM state in this patient was considered to be due to toxic DPH levels. She regained her motor and mental activity within two months after carbamazepine was administered to replace DPH. She was symptom-free when examined at the two-year follow-up. No similar adverse effect of DPH has been reported to date.
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| format | Article |
| id | doaj-art-dcb95d0113244ed1aa4a3ee7156573c5 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 1997-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-dcb95d0113244ed1aa4a3ee7156573c52025-08-20T03:02:15ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211997-07-01393Akinetic mutism due to diphenylhydantoin toxicityS Tütüncüoğlu0M KantarH TekgülC CandanDepartment of Pediatrics, Ege University Faculty of Medicine, Izmir. Akinetic mutism (AM) is a rare, specific, unconscious state. An AM patient seems to be awake, lacks mental activity, is unable to speak, and does not respond to any environmental stimulus. Cyclical sleep and awake states are maintained, and incontinence is present. Various factors such as tumor, vascular events, drug use and radiotherapy are responsible for the development of AM. A 12-year-old epileptic patient displayed AM and diphenylhydantoin toxicity (DPH). She seemed awake, was unable to speak or to understand, and had no movements with either spontaneous or noxious stimuli. Her serum DPH level was greater than 40 micrograms/ml. Magnetic resonance imaging (MRI) showed mild cerebellar atrophy. All known causes of AM were excluded. The AM state in this patient was considered to be due to toxic DPH levels. She regained her motor and mental activity within two months after carbamazepine was administered to replace DPH. She was symptom-free when examined at the two-year follow-up. No similar adverse effect of DPH has been reported to date. https://turkjpediatr.org/article/view/3417 |
| spellingShingle | S Tütüncüoğlu M Kantar H Tekgül C Candan Akinetic mutism due to diphenylhydantoin toxicity The Turkish Journal of Pediatrics |
| title | Akinetic mutism due to diphenylhydantoin toxicity |
| title_full | Akinetic mutism due to diphenylhydantoin toxicity |
| title_fullStr | Akinetic mutism due to diphenylhydantoin toxicity |
| title_full_unstemmed | Akinetic mutism due to diphenylhydantoin toxicity |
| title_short | Akinetic mutism due to diphenylhydantoin toxicity |
| title_sort | akinetic mutism due to diphenylhydantoin toxicity |
| url | https://turkjpediatr.org/article/view/3417 |
| work_keys_str_mv | AT stutuncuoglu akineticmutismduetodiphenylhydantointoxicity AT mkantar akineticmutismduetodiphenylhydantointoxicity AT htekgul akineticmutismduetodiphenylhydantointoxicity AT ccandan akineticmutismduetodiphenylhydantointoxicity |