Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticae
Abstract The rapid evolution of pesticide resistance imposes great pressure on food production. However, how resistance alleles arise and spread across field populations remains largely understood. Here, we study the evolutionary trajectories of resistance alleles in Tetranychus urticae, a rapidly e...
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Nature Portfolio
2025-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08658-9 |
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| author | Lei Chen Li-Xue Guo Hua-Meng Zhang Xiao-Nan Sun Yu-Ting Liu Jie Ji Wen-Xin Xue Nicky Wybouw Thomas Van Leeuwen Xiao-Feng Xue Xiao-Yue Hong Jing-Tao Sun |
| author_facet | Lei Chen Li-Xue Guo Hua-Meng Zhang Xiao-Nan Sun Yu-Ting Liu Jie Ji Wen-Xin Xue Nicky Wybouw Thomas Van Leeuwen Xiao-Feng Xue Xiao-Yue Hong Jing-Tao Sun |
| author_sort | Lei Chen |
| collection | DOAJ |
| description | Abstract The rapid evolution of pesticide resistance imposes great pressure on food production. However, how resistance alleles arise and spread across field populations remains largely understood. Here, we study the evolutionary trajectories of resistance alleles in Tetranychus urticae, a rapidly evolving pest. We sequence the genomes of 258 T. urticae females collected from China. Combined with global reference genomic data, we examine the evolutionary origin(s) of 18 mutations across 10 target-site genes and analyze the global population genetic structure using genome-wide SNPs. Our findings reveal a striking prevalence of multiple independent origins of resistance mutations, with only two of 18 mutations showing an apparent single origin. Population structure and haplotype analyses point to an important role of gene flow in the spread of resistance alleles. Selection analyses reveal pesticide-driven sweeps affecting genetic diversity. These findings advance our understanding of the rapid adaptation of arthropod herbivores to extreme selective pressure. |
| format | Article |
| id | doaj-art-dcb9310078a740878e3dd8bdfffa3c34 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-dcb9310078a740878e3dd8bdfffa3c342025-08-20T03:46:19ZengNature PortfolioCommunications Biology2399-36422025-08-018111710.1038/s42003-025-08658-9Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticaeLei Chen0Li-Xue Guo1Hua-Meng Zhang2Xiao-Nan Sun3Yu-Ting Liu4Jie Ji5Wen-Xin Xue6Nicky Wybouw7Thomas Van Leeuwen8Xiao-Feng Xue9Xiao-Yue Hong10Jing-Tao Sun11Department of Entomology, Nanjing Agricultural UniversityDepartment of Entomology, Nanjing Agricultural UniversityDepartment of Entomology, Nanjing Agricultural UniversityDepartment of Entomology, Nanjing Agricultural UniversityDepartment of Entomology, Nanjing Agricultural UniversityInstitute of Plant Protection, Fujian Academy of Agricultural SciencesTobacco Research Institute, Chinese Academy of Agricultural SciencesDepartment of Biology, Faculty of Sciences, Ghent UniversityLaboratory of Agrozoology, Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent UniversityDepartment of Entomology, Nanjing Agricultural UniversityDepartment of Entomology, Nanjing Agricultural UniversityDepartment of Entomology, Nanjing Agricultural UniversityAbstract The rapid evolution of pesticide resistance imposes great pressure on food production. However, how resistance alleles arise and spread across field populations remains largely understood. Here, we study the evolutionary trajectories of resistance alleles in Tetranychus urticae, a rapidly evolving pest. We sequence the genomes of 258 T. urticae females collected from China. Combined with global reference genomic data, we examine the evolutionary origin(s) of 18 mutations across 10 target-site genes and analyze the global population genetic structure using genome-wide SNPs. Our findings reveal a striking prevalence of multiple independent origins of resistance mutations, with only two of 18 mutations showing an apparent single origin. Population structure and haplotype analyses point to an important role of gene flow in the spread of resistance alleles. Selection analyses reveal pesticide-driven sweeps affecting genetic diversity. These findings advance our understanding of the rapid adaptation of arthropod herbivores to extreme selective pressure.https://doi.org/10.1038/s42003-025-08658-9 |
| spellingShingle | Lei Chen Li-Xue Guo Hua-Meng Zhang Xiao-Nan Sun Yu-Ting Liu Jie Ji Wen-Xin Xue Nicky Wybouw Thomas Van Leeuwen Xiao-Feng Xue Xiao-Yue Hong Jing-Tao Sun Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticae Communications Biology |
| title | Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticae |
| title_full | Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticae |
| title_fullStr | Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticae |
| title_full_unstemmed | Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticae |
| title_short | Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticae |
| title_sort | population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest tetranychus urticae |
| url | https://doi.org/10.1038/s42003-025-08658-9 |
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