<i>Alpinia zerumbet</i> Extract Mitigates PCB 126-Induced Neurotoxicity and Locomotor Impairment in Adult Male Mice
Polychlorinated biphenyls (PCBs) are synthetic chemical compounds that have bioaccumulated and contaminated the entire global ecosystem, causing neurotoxic effects. However, polyphenols may have protective effects against this neurotoxicity. We aimed to investigate the neuroprotective effect of a hy...
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2025-05-01
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| Online Access: | https://www.mdpi.com/2218-0532/93/2/23 |
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| author | Paula Hosana Fernandes da Silva Jemima Isnardo Fernandes Matheus Pontes de Menezes Fabrícia Lima Fontes-Dantas André Luiz Nunes Freitas Rayane Efraim Correa Ulisses Cesar de Araujo Dayane Teixeira Ognibene Cristiane Aguiar da Costa Cláudio Carneiro Filgueiras Alex Christian Manhães Júlio Beltrame Daleprane Angela de Castro Resende Graziele Freitas de Bem |
| author_facet | Paula Hosana Fernandes da Silva Jemima Isnardo Fernandes Matheus Pontes de Menezes Fabrícia Lima Fontes-Dantas André Luiz Nunes Freitas Rayane Efraim Correa Ulisses Cesar de Araujo Dayane Teixeira Ognibene Cristiane Aguiar da Costa Cláudio Carneiro Filgueiras Alex Christian Manhães Júlio Beltrame Daleprane Angela de Castro Resende Graziele Freitas de Bem |
| author_sort | Paula Hosana Fernandes da Silva |
| collection | DOAJ |
| description | Polychlorinated biphenyls (PCBs) are synthetic chemical compounds that have bioaccumulated and contaminated the entire global ecosystem, causing neurotoxic effects. However, polyphenols may have protective effects against this neurotoxicity. We aimed to investigate the neuroprotective effect of a hydroalcoholic extract of fresh leaves of <i>Alpinia zerumbet</i> (ALE), which is rich in polyphenols, on the neurobehavioral changes induced by 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126). We divided C57BL/6 male mice into four groups (<i>n</i> = 40): Control, Control + ALE, PCB, and PCB + ALE. We administered the ALE (50 mg/kg/day) through drinking water and PCB 126 (2 mg/kg/once a week) intraperitoneally for four weeks. The mice were subjected to the elevated plus maze (EPM) and open field (OF) tests in the last week of treatment. PCB 126 reduced locomotor activity, DOPAC levels, dopamine turnover, and D2 receptor expression. This compound also increased lipid peroxidation, tyrosine levels, and BAX expression in the cerebral cortex. Notably, ALE treatment prevented locomotor activity reduction and increased DOPAC levels, dopamine turnover, and D2 receptor expression. Moreover, the extract prevented the PCB-induced increases in BAX expression and lipid peroxidation. Finally, the ALE increased SOD antioxidant activity. Our investigation highlights that using the ALE may serve as a therapeutic strategy against PCB-induced neurotoxicity. |
| format | Article |
| id | doaj-art-dcb7ee12be5a474b8e2289e52688b5cd |
| institution | OA Journals |
| issn | 0036-8709 2218-0532 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Scientia Pharmaceutica |
| spelling | doaj-art-dcb7ee12be5a474b8e2289e52688b5cd2025-08-20T02:21:50ZengMDPI AGScientia Pharmaceutica0036-87092218-05322025-05-019322310.3390/scipharm93020023<i>Alpinia zerumbet</i> Extract Mitigates PCB 126-Induced Neurotoxicity and Locomotor Impairment in Adult Male MicePaula Hosana Fernandes da Silva0Jemima Isnardo Fernandes1Matheus Pontes de Menezes2Fabrícia Lima Fontes-Dantas3André Luiz Nunes Freitas4Rayane Efraim Correa5Ulisses Cesar de Araujo6Dayane Teixeira Ognibene7Cristiane Aguiar da Costa8Cláudio Carneiro Filgueiras9Alex Christian Manhães10Júlio Beltrame Daleprane11Angela de Castro Resende12Graziele Freitas de Bem13Department of Pharmacology and Psychobiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Physiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Pharmacology and Psychobiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Pharmacology and Psychobiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Physiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Physiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Physiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Pharmacology and Psychobiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Pharmacology and Psychobiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Physiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Physiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Basic Experimental Nutrition, Institute of Nutrition, Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Pharmacology and Psychobiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilDepartment of Pharmacology and Psychobiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, BrazilPolychlorinated biphenyls (PCBs) are synthetic chemical compounds that have bioaccumulated and contaminated the entire global ecosystem, causing neurotoxic effects. However, polyphenols may have protective effects against this neurotoxicity. We aimed to investigate the neuroprotective effect of a hydroalcoholic extract of fresh leaves of <i>Alpinia zerumbet</i> (ALE), which is rich in polyphenols, on the neurobehavioral changes induced by 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126). We divided C57BL/6 male mice into four groups (<i>n</i> = 40): Control, Control + ALE, PCB, and PCB + ALE. We administered the ALE (50 mg/kg/day) through drinking water and PCB 126 (2 mg/kg/once a week) intraperitoneally for four weeks. The mice were subjected to the elevated plus maze (EPM) and open field (OF) tests in the last week of treatment. PCB 126 reduced locomotor activity, DOPAC levels, dopamine turnover, and D2 receptor expression. This compound also increased lipid peroxidation, tyrosine levels, and BAX expression in the cerebral cortex. Notably, ALE treatment prevented locomotor activity reduction and increased DOPAC levels, dopamine turnover, and D2 receptor expression. Moreover, the extract prevented the PCB-induced increases in BAX expression and lipid peroxidation. Finally, the ALE increased SOD antioxidant activity. Our investigation highlights that using the ALE may serve as a therapeutic strategy against PCB-induced neurotoxicity.https://www.mdpi.com/2218-0532/93/2/23<i>Alpinia zerumbet</i>polychlorinated biphenylslocomotor deficitsneurotoxicityneurodegenerationdopamine metabolism |
| spellingShingle | Paula Hosana Fernandes da Silva Jemima Isnardo Fernandes Matheus Pontes de Menezes Fabrícia Lima Fontes-Dantas André Luiz Nunes Freitas Rayane Efraim Correa Ulisses Cesar de Araujo Dayane Teixeira Ognibene Cristiane Aguiar da Costa Cláudio Carneiro Filgueiras Alex Christian Manhães Júlio Beltrame Daleprane Angela de Castro Resende Graziele Freitas de Bem <i>Alpinia zerumbet</i> Extract Mitigates PCB 126-Induced Neurotoxicity and Locomotor Impairment in Adult Male Mice Scientia Pharmaceutica <i>Alpinia zerumbet</i> polychlorinated biphenyls locomotor deficits neurotoxicity neurodegeneration dopamine metabolism |
| title | <i>Alpinia zerumbet</i> Extract Mitigates PCB 126-Induced Neurotoxicity and Locomotor Impairment in Adult Male Mice |
| title_full | <i>Alpinia zerumbet</i> Extract Mitigates PCB 126-Induced Neurotoxicity and Locomotor Impairment in Adult Male Mice |
| title_fullStr | <i>Alpinia zerumbet</i> Extract Mitigates PCB 126-Induced Neurotoxicity and Locomotor Impairment in Adult Male Mice |
| title_full_unstemmed | <i>Alpinia zerumbet</i> Extract Mitigates PCB 126-Induced Neurotoxicity and Locomotor Impairment in Adult Male Mice |
| title_short | <i>Alpinia zerumbet</i> Extract Mitigates PCB 126-Induced Neurotoxicity and Locomotor Impairment in Adult Male Mice |
| title_sort | i alpinia zerumbet i extract mitigates pcb 126 induced neurotoxicity and locomotor impairment in adult male mice |
| topic | <i>Alpinia zerumbet</i> polychlorinated biphenyls locomotor deficits neurotoxicity neurodegeneration dopamine metabolism |
| url | https://www.mdpi.com/2218-0532/93/2/23 |
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