Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank
Objective: To investigate the impact of obesity on brain structure and cognition using large neuroimaging and genetic data. Methods: Associations between body mass index (BMI), gray matter volume (GMV), whiter matter hyper-intensities (WMH), and fluid intelligence score (FIS) were estimated in 30283...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242125000016 |
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| author | Panlong Li Xirui Zhu Chun Huang Shan Tian Yuna Li Yuan Qiao Min Liu Jingjing Su Dandan Tian |
| author_facet | Panlong Li Xirui Zhu Chun Huang Shan Tian Yuna Li Yuan Qiao Min Liu Jingjing Su Dandan Tian |
| author_sort | Panlong Li |
| collection | DOAJ |
| description | Objective: To investigate the impact of obesity on brain structure and cognition using large neuroimaging and genetic data. Methods: Associations between body mass index (BMI), gray matter volume (GMV), whiter matter hyper-intensities (WMH), and fluid intelligence score (FIS) were estimated in 30283 participants from the UK Biobank. Longitudinal data analysis was conducted. Genome-wide association studies were applied to explore the genetic loci associations among BMI, GMV, WMH, and FIS. Mendelian Randomization analyses were applied to further estimate the effects of obesity on changes in the brain and cognition. Results: The observational analysis revealed that BMI was negatively associated with GMV (r = -0.15, p < 1×10−24) and positively associated with WMH (r = 0.08, p < 1×10−16). The change in BMI was negatively associated with the change in GMV (r = -0.04, p < 5×10−5). Genetic overlap was observed among BMI, GMV, and FIS at SBK1 (rs2726032), SGF29 (rs17707300), TUFM (rs3088215), AKAP6 (rs1051695), IL27 (rs4788084), and SPI1 (rs3740689 and rs935914). The MR analysis provided evidence that higher BMI was associated with lower GMV (β=-1119.12, p = 5.77 ×10−6), higher WMH (β=42.76, p = 6.37 ×10−4), and lower FIS (β=-0.081, p = 1.92 ×10−23). Conclusions: The phenotypic and genetic association between obesity and aging brain and cognitive decline suggested that weight control could be a promising strategy for slowing the aging brain. |
| format | Article |
| id | doaj-art-dcb7913c755c43f9a85ebe087e0193a0 |
| institution | DOAJ |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-dcb7913c755c43f9a85ebe087e0193a02025-08-20T03:20:58ZengElsevierIBRO Neuroscience Reports2667-24212025-06-011814815710.1016/j.ibneur.2025.01.001Effects of obesity on aging brain and cognitive decline: A cohort study from the UK BiobankPanlong Li0Xirui Zhu1Chun Huang2Shan Tian3Yuna Li4Yuan Qiao5Min Liu6Jingjing Su7Dandan Tian8School of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, ChinaSchool of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, ChinaSchool of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, ChinaDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Hypertension, Henan Provincial People’s Hospital & Zhengzhou University People’s Hospital, Zhengzhou, ChinaDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding authors.Department of Hypertension, Henan Provincial People’s Hospital & Zhengzhou University People’s Hospital, Zhengzhou, China; Corresponding authors.Objective: To investigate the impact of obesity on brain structure and cognition using large neuroimaging and genetic data. Methods: Associations between body mass index (BMI), gray matter volume (GMV), whiter matter hyper-intensities (WMH), and fluid intelligence score (FIS) were estimated in 30283 participants from the UK Biobank. Longitudinal data analysis was conducted. Genome-wide association studies were applied to explore the genetic loci associations among BMI, GMV, WMH, and FIS. Mendelian Randomization analyses were applied to further estimate the effects of obesity on changes in the brain and cognition. Results: The observational analysis revealed that BMI was negatively associated with GMV (r = -0.15, p < 1×10−24) and positively associated with WMH (r = 0.08, p < 1×10−16). The change in BMI was negatively associated with the change in GMV (r = -0.04, p < 5×10−5). Genetic overlap was observed among BMI, GMV, and FIS at SBK1 (rs2726032), SGF29 (rs17707300), TUFM (rs3088215), AKAP6 (rs1051695), IL27 (rs4788084), and SPI1 (rs3740689 and rs935914). The MR analysis provided evidence that higher BMI was associated with lower GMV (β=-1119.12, p = 5.77 ×10−6), higher WMH (β=42.76, p = 6.37 ×10−4), and lower FIS (β=-0.081, p = 1.92 ×10−23). Conclusions: The phenotypic and genetic association between obesity and aging brain and cognitive decline suggested that weight control could be a promising strategy for slowing the aging brain.http://www.sciencedirect.com/science/article/pii/S2667242125000016ObesityGray matter atrophyWhite matter hyper-intensitiesGenetic overlapMendelian randomization |
| spellingShingle | Panlong Li Xirui Zhu Chun Huang Shan Tian Yuna Li Yuan Qiao Min Liu Jingjing Su Dandan Tian Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank IBRO Neuroscience Reports Obesity Gray matter atrophy White matter hyper-intensities Genetic overlap Mendelian randomization |
| title | Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank |
| title_full | Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank |
| title_fullStr | Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank |
| title_full_unstemmed | Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank |
| title_short | Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank |
| title_sort | effects of obesity on aging brain and cognitive decline a cohort study from the uk biobank |
| topic | Obesity Gray matter atrophy White matter hyper-intensities Genetic overlap Mendelian randomization |
| url | http://www.sciencedirect.com/science/article/pii/S2667242125000016 |
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