An Efficient and Mild Method for the Synthesis and Hydrazinolysis of N-Glyoxylamino Acid Esters
N-Glyoxylamino acid ester derivatives were synthesized via the ring opening of N-acetylisatin using moderate conditions. During the hydrazinolysis of N-glyoxylamino acid ester derivatives with hydrazine hydrate (80%) in methanol, unexpected reduction of the α-keto group occurred to afford N-acylamin...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/901745 |
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| author | Ayman El-Faham Zainab Al Marhoon Ahmed Abdel-Megeed Mohamed Siddiqui |
| author_facet | Ayman El-Faham Zainab Al Marhoon Ahmed Abdel-Megeed Mohamed Siddiqui |
| author_sort | Ayman El-Faham |
| collection | DOAJ |
| description | N-Glyoxylamino acid ester derivatives were synthesized via the ring opening of N-acetylisatin using moderate conditions. During the hydrazinolysis of N-glyoxylamino acid ester derivatives with hydrazine hydrate (80%) in methanol, unexpected reduction of the α-keto group occurred to afford N-acylamino acid hydrazide derivatives in good yield (80–90%) (Wolff-Kishner type reaction). All the synthesized compounds were characterized by 1H NMR, 13C NMR, and elemental microanalysis. |
| format | Article |
| id | doaj-art-dcb74b3ce3424c779a6329c83eaaf885 |
| institution | DOAJ |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-dcb74b3ce3424c779a6329c83eaaf8852025-08-20T03:23:56ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/901745901745An Efficient and Mild Method for the Synthesis and Hydrazinolysis of N-Glyoxylamino Acid EstersAyman El-Faham0Zainab Al Marhoon1Ahmed Abdel-Megeed2Mohamed Siddiqui3Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaN-Glyoxylamino acid ester derivatives were synthesized via the ring opening of N-acetylisatin using moderate conditions. During the hydrazinolysis of N-glyoxylamino acid ester derivatives with hydrazine hydrate (80%) in methanol, unexpected reduction of the α-keto group occurred to afford N-acylamino acid hydrazide derivatives in good yield (80–90%) (Wolff-Kishner type reaction). All the synthesized compounds were characterized by 1H NMR, 13C NMR, and elemental microanalysis.http://dx.doi.org/10.1155/2013/901745 |
| spellingShingle | Ayman El-Faham Zainab Al Marhoon Ahmed Abdel-Megeed Mohamed Siddiqui An Efficient and Mild Method for the Synthesis and Hydrazinolysis of N-Glyoxylamino Acid Esters Journal of Chemistry |
| title | An Efficient and Mild Method for the Synthesis and Hydrazinolysis of N-Glyoxylamino Acid Esters |
| title_full | An Efficient and Mild Method for the Synthesis and Hydrazinolysis of N-Glyoxylamino Acid Esters |
| title_fullStr | An Efficient and Mild Method for the Synthesis and Hydrazinolysis of N-Glyoxylamino Acid Esters |
| title_full_unstemmed | An Efficient and Mild Method for the Synthesis and Hydrazinolysis of N-Glyoxylamino Acid Esters |
| title_short | An Efficient and Mild Method for the Synthesis and Hydrazinolysis of N-Glyoxylamino Acid Esters |
| title_sort | efficient and mild method for the synthesis and hydrazinolysis of n glyoxylamino acid esters |
| url | http://dx.doi.org/10.1155/2013/901745 |
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