Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial
BackgroundCanine pneumonia is a serious respiratory disease often associated with Canine Infectious Respiratory Disease (CIRD). Current treatment strategies primarily rely on antibiotics and corticosteroids; however, the emergence of antibiotic resistance and potential side effects from prolonged co...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1530318/full |
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| author | Jinzhao Ji Jinzhao Ji Xiaoqing Ding Xiaoqing Ding Chuanli Liu Chuanli Liu Lingling Dai Lingling Dai Junting Yu Junting Yu Linghao Li Linghao Li Shaobing Wan Shaobing Wan Yangyang Song Junqing Zhao Zhetong Su Kun Jia Kun Jia Shoujun Li Shoujun Li |
| author_facet | Jinzhao Ji Jinzhao Ji Xiaoqing Ding Xiaoqing Ding Chuanli Liu Chuanli Liu Lingling Dai Lingling Dai Junting Yu Junting Yu Linghao Li Linghao Li Shaobing Wan Shaobing Wan Yangyang Song Junqing Zhao Zhetong Su Kun Jia Kun Jia Shoujun Li Shoujun Li |
| author_sort | Jinzhao Ji |
| collection | DOAJ |
| description | BackgroundCanine pneumonia is a serious respiratory disease often associated with Canine Infectious Respiratory Disease (CIRD). Current treatment strategies primarily rely on antibiotics and corticosteroids; however, the emergence of antibiotic resistance and potential side effects from prolonged corticosteroid use limit the effectiveness of these therapies in clinical practice. These challenges highlight the urgent need for alternative treatments. Anemoside B4 (AB4), derived from the traditional Chinese medicine Pulsatilla, has shown promise in preclinical studies for modulating inflammatory responses and improving clinical symptoms of pneumonia. Therefore, AB4 may offer a valuable alternative treatment option for canine pneumonia in veterinary medicine.MethodsA prospective, randomized controlled trial was conducted at the Veterinary Drug Research and Evaluation Center of South China Agricultural University. Seventy-two dogs with mild-to-moderate pneumonia were randomly assigned to one of three groups: AB4, placebo, or Chuanxinlian injection (CXL). The primary outcome was the effect of AB4 on comprehensive clinical scoring of canine pneumonia; secondary outcomes included recovery times for primary symptoms and efficacy assessments. Additionally, AB4′s safety in clinical applications was evaluated.ResultsThe AB4 group demonstrated significantly lower composite clinical scores on Days 7 and 14 compared to the placebo group (p = 0.033 and p = 0.000, respectively). Significant differences in recovery times for fever and dyspnea were observed between the AB4 and placebo groups (p = 0.041 and p = 0.024, respectively). Moreover, the cure rate and overall efficacy on Day 14 were significantly higher in the AB4 group than those in the placebo group (p = 0.001 and p = 0.009, respectively).ConclusionThese findings suggest that AB4 may be a promising treatment option for canine pneumonia, potentially serving as an alternative to traditional therapies. Further research is needed to explore its clinical potential in veterinary medicine. |
| format | Article |
| id | doaj-art-dcb233b6cd06499186aa9bf436983c73 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-dcb233b6cd06499186aa9bf436983c732025-02-12T07:26:20ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-02-011210.3389/fvets.2025.15303181530318Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trialJinzhao Ji0Jinzhao Ji1Xiaoqing Ding2Xiaoqing Ding3Chuanli Liu4Chuanli Liu5Lingling Dai6Lingling Dai7Junting Yu8Junting Yu9Linghao Li10Linghao Li11Shaobing Wan12Shaobing Wan13Yangyang Song14Junqing Zhao15Zhetong Su16Kun Jia17Kun Jia18Shoujun Li19Shoujun Li20College of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaGuangdong Technological Engineering Research Center for Pet, Guangzhou, ChinaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaGuangdong Technological Engineering Research Center for Pet, Guangzhou, ChinaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaGuangdong Technological Engineering Research Center for Pet, Guangzhou, ChinaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaGuangdong Technological Engineering Research Center for Pet, Guangzhou, ChinaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaGuangdong Technological Engineering Research Center for Pet, Guangzhou, ChinaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaGuangdong Technological Engineering Research Center for Pet, Guangzhou, ChinaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaGuangdong Technological Engineering Research Center for Pet, Guangzhou, ChinaGuangxi Innovate Pharmaceutical Co., Ltd, Guangxi, ChinaGuangxi Innovate Pharmaceutical Co., Ltd, Guangxi, ChinaGuangxi Innovate Pharmaceutical Co., Ltd, Guangxi, ChinaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaGuangdong Technological Engineering Research Center for Pet, Guangzhou, ChinaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaGuangdong Technological Engineering Research Center for Pet, Guangzhou, ChinaBackgroundCanine pneumonia is a serious respiratory disease often associated with Canine Infectious Respiratory Disease (CIRD). Current treatment strategies primarily rely on antibiotics and corticosteroids; however, the emergence of antibiotic resistance and potential side effects from prolonged corticosteroid use limit the effectiveness of these therapies in clinical practice. These challenges highlight the urgent need for alternative treatments. Anemoside B4 (AB4), derived from the traditional Chinese medicine Pulsatilla, has shown promise in preclinical studies for modulating inflammatory responses and improving clinical symptoms of pneumonia. Therefore, AB4 may offer a valuable alternative treatment option for canine pneumonia in veterinary medicine.MethodsA prospective, randomized controlled trial was conducted at the Veterinary Drug Research and Evaluation Center of South China Agricultural University. Seventy-two dogs with mild-to-moderate pneumonia were randomly assigned to one of three groups: AB4, placebo, or Chuanxinlian injection (CXL). The primary outcome was the effect of AB4 on comprehensive clinical scoring of canine pneumonia; secondary outcomes included recovery times for primary symptoms and efficacy assessments. Additionally, AB4′s safety in clinical applications was evaluated.ResultsThe AB4 group demonstrated significantly lower composite clinical scores on Days 7 and 14 compared to the placebo group (p = 0.033 and p = 0.000, respectively). Significant differences in recovery times for fever and dyspnea were observed between the AB4 and placebo groups (p = 0.041 and p = 0.024, respectively). Moreover, the cure rate and overall efficacy on Day 14 were significantly higher in the AB4 group than those in the placebo group (p = 0.001 and p = 0.009, respectively).ConclusionThese findings suggest that AB4 may be a promising treatment option for canine pneumonia, potentially serving as an alternative to traditional therapies. Further research is needed to explore its clinical potential in veterinary medicine.https://www.frontiersin.org/articles/10.3389/fvets.2025.1530318/fullanemoside B4canine pneumoniarandomized controlled trialinflammationphytomedicine |
| spellingShingle | Jinzhao Ji Jinzhao Ji Xiaoqing Ding Xiaoqing Ding Chuanli Liu Chuanli Liu Lingling Dai Lingling Dai Junting Yu Junting Yu Linghao Li Linghao Li Shaobing Wan Shaobing Wan Yangyang Song Junqing Zhao Zhetong Su Kun Jia Kun Jia Shoujun Li Shoujun Li Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial Frontiers in Veterinary Science anemoside B4 canine pneumonia randomized controlled trial inflammation phytomedicine |
| title | Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial |
| title_full | Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial |
| title_fullStr | Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial |
| title_full_unstemmed | Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial |
| title_short | Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial |
| title_sort | efficacy and safety of anemoside b4 in canine pneumonia treatment a prospective randomized controlled trial |
| topic | anemoside B4 canine pneumonia randomized controlled trial inflammation phytomedicine |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1530318/full |
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