The role of effective albumin in chronic liver disease
Effective albumin refers to serum albumin with intact structure and function. In the course of chronic liver disease, some serum albumin loses its functional integrity through different post-translational modifications such as oxidation and glycosylation. Level of effective albumin is lower in patie...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2024-12-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-12-1707.pdf |
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| _version_ | 1850124303906897920 |
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| author | LIN Jun, LI Zepeng, YU Junying |
| author_facet | LIN Jun, LI Zepeng, YU Junying |
| author_sort | LIN Jun, LI Zepeng, YU Junying |
| collection | DOAJ |
| description | Effective albumin refers to serum albumin with intact structure and function. In the course of chronic liver disease, some serum albumin loses its functional integrity through different post-translational modifications such as oxidation and glycosylation. Level of effective albumin is lower in patients with decompensated cirrhosis and is significantly correlated with patient survival, underscoring that they are more sensitive than total serum albumin in reflecting the actual state of liver function. In addition, effective albumin not only serves as a predictor, but also plays a key role in the treatment of chronic liver disease by improving albumin preparations and developing new therapeutics. |
| format | Article |
| id | doaj-art-dcacad472c3544d6932b60ff82595894 |
| institution | OA Journals |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj-art-dcacad472c3544d6932b60ff825958942025-08-20T02:34:20ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252024-12-0144121707171110.16352/j.issn.1001-6325.2024.12.1707The role of effective albumin in chronic liver diseaseLIN Jun, LI Zepeng, YU Junying01. Guangxi University of Traditional Chinese Medicine, Nanning 530000; ;2. Department of Infectious Diseases, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou 545000, ChinaEffective albumin refers to serum albumin with intact structure and function. In the course of chronic liver disease, some serum albumin loses its functional integrity through different post-translational modifications such as oxidation and glycosylation. Level of effective albumin is lower in patients with decompensated cirrhosis and is significantly correlated with patient survival, underscoring that they are more sensitive than total serum albumin in reflecting the actual state of liver function. In addition, effective albumin not only serves as a predictor, but also plays a key role in the treatment of chronic liver disease by improving albumin preparations and developing new therapeutics.https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-12-1707.pdfeffective albumin|liver cirrhosis|liver failure|liver cancer |
| spellingShingle | LIN Jun, LI Zepeng, YU Junying The role of effective albumin in chronic liver disease Jichu yixue yu linchuang effective albumin|liver cirrhosis|liver failure|liver cancer |
| title | The role of effective albumin in chronic liver disease |
| title_full | The role of effective albumin in chronic liver disease |
| title_fullStr | The role of effective albumin in chronic liver disease |
| title_full_unstemmed | The role of effective albumin in chronic liver disease |
| title_short | The role of effective albumin in chronic liver disease |
| title_sort | role of effective albumin in chronic liver disease |
| topic | effective albumin|liver cirrhosis|liver failure|liver cancer |
| url | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-12-1707.pdf |
| work_keys_str_mv | AT linjunlizepengyujunying theroleofeffectivealbumininchronicliverdisease AT linjunlizepengyujunying roleofeffectivealbumininchronicliverdisease |