Association between Human papillomavirus infection and abnormal cytopathology of uterine cervix in Baghdad women
Background: Human papillomavirus (HPV) is considered one of sexually transferred disease in the world and it is considered as one of the causative agents of cervical cancer. Cervical cytology is used widely as the initial tool in cervical cancer screening worldwide. Objective: The purpose of this s...
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| Format: | Article |
| Language: | English |
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Al-Nahrain University/ Biotechnology Research Center
2025-04-01
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| Series: | مجلة مركز بحوث التقنيات الاحيائية |
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| Online Access: | https://jobrc.org/index.php/jobrc/article/view/831 |
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| author | Nawres A. Tawfeeq Thamer A. Hussein Hussein A. Hasan Haider G. Hussein Wissam J. Mohammed Dina S. Ibraheem |
| author_facet | Nawres A. Tawfeeq Thamer A. Hussein Hussein A. Hasan Haider G. Hussein Wissam J. Mohammed Dina S. Ibraheem |
| author_sort | Nawres A. Tawfeeq |
| collection | DOAJ |
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Background: Human papillomavirus (HPV) is considered one of sexually transferred disease in the world and it is considered as one of the causative agents of cervical cancer. Cervical cytology is used widely as the initial tool in cervical cancer screening worldwide. Objective: The purpose of this study was to analyze the correlation between cytological findings from Papanicolaou (pap.)-stained cervical smears and cases of HPV infection of the uterine cervix as identified by Polymerase Chain Reaction (PCR) testing. Methodology: Between June 2021 and December 2022, retrospective study for cervical smears of 370 Baghdad women (attending to the Central Public Health Laboratory (CPHL)/Ministry of Health in Baghdad) were stained by the Pap procedure and categorized by the Bethesda classification system, High Risk-Human papilloma Virus (HR-HPV) detection was used to analyze the HPV status of the cervical samples that were collected Results: HR-HPV testing was done for 370 women (230 women that have shown Positive results for HR-HPV and 140 were negative for HPV). Our result showed highly significant differences at (P ≤ 0.01) for HR-HPV genotype and abnormal Pap smear with High grade squamous intraepithelial lesion (HSIL) at 23.9 %, while it was at 41.3% with low grade squamous intraepithelial lesion (LSIL) Pap smear which represent the highest rate, in addition to 34.7% for abnormal Pap smear with atypical squamous cells of undetermined significance (ASCUS) classification Conclusion: This study has shown that molecular investigation for HR-HPV might be essential for diagnosis of patients with proven epithelial abnormality in their Pap smears.
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| format | Article |
| id | doaj-art-dca88f886bca4b49a93fa7ca91066078 |
| institution | OA Journals |
| issn | 1815-1140 2708-1370 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Al-Nahrain University/ Biotechnology Research Center |
| record_format | Article |
| series | مجلة مركز بحوث التقنيات الاحيائية |
| spelling | doaj-art-dca88f886bca4b49a93fa7ca910660782025-08-20T02:18:35ZengAl-Nahrain University/ Biotechnology Research Centerمجلة مركز بحوث التقنيات الاحيائية1815-11402708-13702025-04-0119210.24126/jobrc.2025.19.2.831Association between Human papillomavirus infection and abnormal cytopathology of uterine cervix in Baghdad womenNawres A. Tawfeeq0Thamer A. Hussein 1Hussein A. Hasan 2Haider G. Hussein 3Wissam J. Mohammed 4Dina S. Ibraheem Central Public Health Laboratory / Public Health Directorate/ Ministry of health/ Baghdad /Iraq Central Public Health Laboratory / Public Health Directorate/ Ministry of health/ Baghdad /Iraq Central Public Health Laboratory / Public Health Directorate/ Ministry of health/ Baghdad /Iraq Central Public Health Laboratory / Public Health Directorate/ Ministry of health/ Baghdad /Iraq Central Public Health Laboratory / Public Health Directorate/ Ministry of health/ Baghdad /Iraq Background: Human papillomavirus (HPV) is considered one of sexually transferred disease in the world and it is considered as one of the causative agents of cervical cancer. Cervical cytology is used widely as the initial tool in cervical cancer screening worldwide. Objective: The purpose of this study was to analyze the correlation between cytological findings from Papanicolaou (pap.)-stained cervical smears and cases of HPV infection of the uterine cervix as identified by Polymerase Chain Reaction (PCR) testing. Methodology: Between June 2021 and December 2022, retrospective study for cervical smears of 370 Baghdad women (attending to the Central Public Health Laboratory (CPHL)/Ministry of Health in Baghdad) were stained by the Pap procedure and categorized by the Bethesda classification system, High Risk-Human papilloma Virus (HR-HPV) detection was used to analyze the HPV status of the cervical samples that were collected Results: HR-HPV testing was done for 370 women (230 women that have shown Positive results for HR-HPV and 140 were negative for HPV). Our result showed highly significant differences at (P ≤ 0.01) for HR-HPV genotype and abnormal Pap smear with High grade squamous intraepithelial lesion (HSIL) at 23.9 %, while it was at 41.3% with low grade squamous intraepithelial lesion (LSIL) Pap smear which represent the highest rate, in addition to 34.7% for abnormal Pap smear with atypical squamous cells of undetermined significance (ASCUS) classification Conclusion: This study has shown that molecular investigation for HR-HPV might be essential for diagnosis of patients with proven epithelial abnormality in their Pap smears. https://jobrc.org/index.php/jobrc/article/view/831Human Papilloma virus (HPV)Pap smear, abnormal cervical findings (cytological changings) |
| spellingShingle | Nawres A. Tawfeeq Thamer A. Hussein Hussein A. Hasan Haider G. Hussein Wissam J. Mohammed Dina S. Ibraheem Association between Human papillomavirus infection and abnormal cytopathology of uterine cervix in Baghdad women مجلة مركز بحوث التقنيات الاحيائية Human Papilloma virus (HPV) Pap smear , abnormal cervical findings (cytological changings) |
| title | Association between Human papillomavirus infection and abnormal cytopathology of uterine cervix in Baghdad women |
| title_full | Association between Human papillomavirus infection and abnormal cytopathology of uterine cervix in Baghdad women |
| title_fullStr | Association between Human papillomavirus infection and abnormal cytopathology of uterine cervix in Baghdad women |
| title_full_unstemmed | Association between Human papillomavirus infection and abnormal cytopathology of uterine cervix in Baghdad women |
| title_short | Association between Human papillomavirus infection and abnormal cytopathology of uterine cervix in Baghdad women |
| title_sort | association between human papillomavirus infection and abnormal cytopathology of uterine cervix in baghdad women |
| topic | Human Papilloma virus (HPV) Pap smear , abnormal cervical findings (cytological changings) |
| url | https://jobrc.org/index.php/jobrc/article/view/831 |
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