Functional loss of rffG and rfbB, encoding dTDP-glucose 4,6-dehydratase, alters colony morphology, cell shape, motility and virulence in Salmonella Typhimurium

Functional loss of rffG and rfbB, encoding dTDP-glucose 4,6-dehydratase, alters colony morphology, cell shape, motility and virulence in Salmonella Typhimurium

Lipopolysaccharide (LPS) O-antigen and enterobacterial common antigen (ECA) play crucial roles in maintaining the outer membrane in Gram-negative bacteria. Mutations in the biosynthetic pathways of LPS and ECA may lead to accumulation of intermediates, resulting in morphological changes and activati...

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Bibliographic Details
Main Authors: Subhashish Chakraborty, Pip Banerjee, Joel P. Joseph, Sanmoy Pathak, Taru Verma, Aagosh Kishor Karhale, Deepti Chandra, Mrinmoy Das, Pritam Saha, Dipankar Nandi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
Subjects:
lipopolysaccharide
enterobacterial common antigen
Salmonella Typhimurium
rfbB
rffG
dTDP-D-glucose 4
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1572117/full
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