An Effective Liposome-Based Nanodelivery System for Naphthalene Derivative Polyamines with Antitumor Activity
This study focuses on the development of a novel liposome-based nanodelivery system designed to encapsulate polyamine-1, a compound with potential anti-tumor properties. The main objective of this work was to enhance the therapeutic and imaging potential of polyamine-1 by incorporating it into lipos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/11/1347 |
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| author | Isabel Pont Rubén Felipe Juan C. Frías Javier U. Chicote Antonio García-España Enrique García-España M. Teresa Albelda |
| author_facet | Isabel Pont Rubén Felipe Juan C. Frías Javier U. Chicote Antonio García-España Enrique García-España M. Teresa Albelda |
| author_sort | Isabel Pont |
| collection | DOAJ |
| description | This study focuses on the development of a novel liposome-based nanodelivery system designed to encapsulate polyamine-1, a compound with potential anti-tumor properties. The main objective of this work was to enhance the therapeutic and imaging potential of polyamine-1 by incorporating it into liposome-based nanoparticles, which were functionalized with a gadolinium complex for imaging purposes and a fluorescent phospholipid for tracking applications. These nanoparticles were characterized by measuring their size, shape, polydispersity index, zeta potential and encapsulation efficiency. In vitro experiments were conducted to evaluate the antitumor activity, specifically determining the cytotoxicity of both free and encapsulated polyamine-1 in cancerous and non-cancerous cell lines. Additionally, the study shows the enhanced signal intensity of gadolinium-loaded liposomes by T1-weighted MRI, highlighting their imaging potential. The experimental results suggest that this liposome-based nanodelivery system not only has therapeutic potential in targeted cancer therapy but also could be advantageous for diagnostic imaging, particularly in MRI applications. |
| format | Article |
| id | doaj-art-dc95e95985c546a2a82c9d7bb0faf9ab |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-dc95e95985c546a2a82c9d7bb0faf9ab2025-08-20T02:08:13ZengMDPI AGBiomolecules2218-273X2024-10-011411134710.3390/biom14111347An Effective Liposome-Based Nanodelivery System for Naphthalene Derivative Polyamines with Antitumor ActivityIsabel Pont0Rubén Felipe1Juan C. Frías2Javier U. Chicote3Antonio García-España4Enrique García-España5M. Teresa Albelda6Instituto de Ciencia Molecular, Departamento de Química Inorgánica, Universidad de Valencia, 46010 Valencia, SpainInstituto de Ciencia Molecular, Departamento de Química Inorgánica, Universidad de Valencia, 46010 Valencia, SpainDepartamento de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, SpainUnitat de Recerca, Hospital Joan XXIII, Institut de Investigació Sanitaria Pere Virgili (IISPV), Universitat Roviri i Virgili, 43002 Tarragona, SpainUnitat de Recerca, Hospital Joan XXIII, Institut de Investigació Sanitaria Pere Virgili (IISPV), Universitat Roviri i Virgili, 43002 Tarragona, SpainInstituto de Ciencia Molecular, Departamento de Química Inorgánica, Universidad de Valencia, 46010 Valencia, SpainDepartment of Inorganic Chemistry, University of Valencia, 46010 Burjassot, SpainThis study focuses on the development of a novel liposome-based nanodelivery system designed to encapsulate polyamine-1, a compound with potential anti-tumor properties. The main objective of this work was to enhance the therapeutic and imaging potential of polyamine-1 by incorporating it into liposome-based nanoparticles, which were functionalized with a gadolinium complex for imaging purposes and a fluorescent phospholipid for tracking applications. These nanoparticles were characterized by measuring their size, shape, polydispersity index, zeta potential and encapsulation efficiency. In vitro experiments were conducted to evaluate the antitumor activity, specifically determining the cytotoxicity of both free and encapsulated polyamine-1 in cancerous and non-cancerous cell lines. Additionally, the study shows the enhanced signal intensity of gadolinium-loaded liposomes by T1-weighted MRI, highlighting their imaging potential. The experimental results suggest that this liposome-based nanodelivery system not only has therapeutic potential in targeted cancer therapy but also could be advantageous for diagnostic imaging, particularly in MRI applications.https://www.mdpi.com/2218-273X/14/11/1347liposomespolyaminescytotoxicitycancer cells |
| spellingShingle | Isabel Pont Rubén Felipe Juan C. Frías Javier U. Chicote Antonio García-España Enrique García-España M. Teresa Albelda An Effective Liposome-Based Nanodelivery System for Naphthalene Derivative Polyamines with Antitumor Activity Biomolecules liposomes polyamines cytotoxicity cancer cells |
| title | An Effective Liposome-Based Nanodelivery System for Naphthalene Derivative Polyamines with Antitumor Activity |
| title_full | An Effective Liposome-Based Nanodelivery System for Naphthalene Derivative Polyamines with Antitumor Activity |
| title_fullStr | An Effective Liposome-Based Nanodelivery System for Naphthalene Derivative Polyamines with Antitumor Activity |
| title_full_unstemmed | An Effective Liposome-Based Nanodelivery System for Naphthalene Derivative Polyamines with Antitumor Activity |
| title_short | An Effective Liposome-Based Nanodelivery System for Naphthalene Derivative Polyamines with Antitumor Activity |
| title_sort | effective liposome based nanodelivery system for naphthalene derivative polyamines with antitumor activity |
| topic | liposomes polyamines cytotoxicity cancer cells |
| url | https://www.mdpi.com/2218-273X/14/11/1347 |
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